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ADIPOR1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS631276

The adiponectin receptors, ADIPOR1 and ADIPOR2, serve as receptors for globular and full-length adiponectin and mediate increased AMPK and PPAR-alpha ligand activities, as well as fatty acid oxidation and glucose uptake by adiponectin. More details

$895 / 0.2 mL +1 FREE 8GB USB
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
ADIPOR1, Polyclonal Antibody
Full Product Name
ADIPOR1, CT (Adiponectin Receptor Protein 1, Progestin And adipoQ Receptor Family Member I, CGI-45, PAQR1, TESBP1A)
Product Gene Name
anti-ADIPOR1 antibody
Product Synonym Names
Anti -ADIPOR1, CT (Adiponectin Receptor Protein 1, Progestin And adipoQ Receptor Family Member I, CGI-45, PAQR1, TESBP1A)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Specificity
Recognizes human ADIPOR1.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
42,616 Da
Chromosome Location
Chromosome: 1; NC_000001.10 (202909960..202927700, complement). Location: 1p36.13-q41
OMIM
607945
3D Structure
ModBase 3D Structure for Q96A54
Immunogen
Synthetic peptide selected from the C-term region of human ADIPOR1 (KLH).

Product Categories/Family for anti-ADIPOR1 antibody

Antibodies; Abs to Receptors
Applications Tested/Suitable for anti-ADIPOR1 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-ADIPOR1 antibody
Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1:1,000
Western Blot: 1:100-1:500

Western Blot (WB) of anti-ADIPOR1 antibody

Western Blot analysis in Y79 cell line lysates (35ug/lane) using MBS631276. ADIPOR1 (arrow) was detected using MBS631276.
Rabbit Anti-ADIPOR1 Polyclonal Antibody – Cat# MBS631276

Immunohistochemistry (IHC) of anti-ADIPOR1 antibody

Immunohistochemistry analysis in formalin-fixed and paraffin-embedded human hepatocarcinoma using AMBS631276, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of MBS631276 for immunohistochemistry.
Rabbit Anti-ADIPOR1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS631276

Flow Cytometry (FC/FACS) of anti-ADIPOR1 antibody

Flow Cytometric analysis of widr cells using MBS631276 (bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-ADIPOR1 Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS631276

Flow Cytometry (FC/FACS) of anti-ADIPOR1 antibody

Flow Cytometric analysis of widr cells using MBS631276 (bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-ADIPOR1 Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS631276

Other Notes

Small volumes of anti-ADIPOR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ADIPOR1 purchase

MBS631276 is an antibody targeting ADIPOR1. Also known as ADIPOR1, CT (Adiponectin Receptor Protein 1, Progestin And adipoQ Receptor Family Member I, CGI-45, PAQR1, TESBP1A). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ADIPOR1. It may not necessarily be applicable to this product.

NCBI GI #
189095248
NCBI GeneID
51094
NCBI Accession #
NP_001121159.1
UniProt Primary Accession #
Q96A54
UniProt Secondary Accession #
Q53HS7; Q53YY6; Q9Y360; B3KMB0
UniProt Related Accession #
Q96A54
GenBank Nucleotide #
NM_001127687.1
NCBI Official Full Name
adiponectin receptor protein 1
NCBI Official Synonym Full Names
adiponectin receptor 1
NCBI Official Symbol
ADIPOR1
NCBI Official Synonym Symbols
CGI45; PAQR1; ACDCR1; CGI-45; TESBP1A; FLJ25385; FLJ42464
UniProt Protein Name
Adiponectin receptor protein 1
UniProt Synonym Protein Names
Progestin and adipoQ receptor family member I
Protein Family
Adiponectin receptor protein
UniProt Gene Name
ADIPOR1
UniProt Synonym Gene Names
PAQR1; TESBP1A
UniProt Entry Name
ADR1_HUMAN
NCBI Protein Information
adiponectin receptor protein 1; OTTHUMP00000038805; OTTHUMP00000038806; progestin and adipoQ receptor family member I

NCBI Summary for ADIPOR1

The adiponectin receptors, ADIPOR1 and ADIPOR2 (MIM 607946), serve as receptors for globular and full-length adiponectin (MIM 605441) and mediate increased AMPK (see MIM 602739) and PPAR-alpha (PPARA; MIM 170998) ligand activities, as well as fatty acid oxidation and glucose uptake by adiponectin (Yamauchi et al., 2003 [PubMed 12802337]).[supplied by OMIM]
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UniProt Comments for ADIPOR1

ADIPOR1: Receptor for globular and full-length adiponectin (APM1), an essential hormone secreted by adipocytes that acts as an antidiabetic. Probably involved in metabolic pathways that regulate lipid metabolism such as fatty acid oxidation. Mediates increased AMPK, PPARA ligand activity, fatty acid oxidation and glucose uptake by adiponectin. Has some high-affinity receptor for globular adiponectin but low-affinity receptor for full-length adiponectin. Belongs to the ADIPOR family.

Protein type: Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 1q32.1

Cellular Component: membrane; integral to membrane; plasma membrane

Molecular Function: adiponectin binding; identical protein binding; hormone binding; protein heterodimerization activity; receptor activity; protein kinase binding

Biological Process: hormone-mediated signaling; positive regulation of JAK-STAT cascade; adiponectin-mediated signaling pathway; fatty acid oxidation; positive regulation of insulin receptor signaling pathway; negative regulation of cell growth; leptin-mediated signaling pathway
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Research Articles on ADIPOR1

1. Adiponectin increases MMP-3 expression and activity by binding to the AdipoR1 receptor and activation of p38 and AMPK, resulting in the activations of NF-kB on the MMP-3 promoter and contribute cartilage destruction during arthritis

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ADIPOR1 antibody

 Reference Product  PubMed Publications
 APPL1 antibody  >18 publications with ADIPOR1 and APPL1

Pathways associated with anti-ADIPOR1 antibody

 Products by Pathway  Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram

Diseases associated with anti-ADIPOR1 antibody

 Disease Name  Pubmed Publications
 Obesity Antibodies  >133 publications with ADIPOR1 and Obesity
 Insulin Resistance Antibodies  >130 publications with ADIPOR1 and Insulin Resistance
 Fatty Liver Antibodies  >47 publications with ADIPOR1 and Fatty Liver
 Neoplasms Antibodies  >46 publications with ADIPOR1 and Neoplasms
 Diabetes Mellitus, Type 2 Antibodies  >45 publications with ADIPOR1 and Diabetes Mellitus, Type 2
 Inflammation Antibodies  >33 publications with ADIPOR1 and Inflammation
 Carcinoma Antibodies  >18 publications with ADIPOR1 and Carcinoma
 Hyperglycemia Antibodies  >17 publications with ADIPOR1 and Hyperglycemia
 Breast Neoplasms Antibodies  >16 publications with ADIPOR1 and Breast Neoplasms
 Fibrosis Antibodies  >16 publications with ADIPOR1 and Fibrosis

Organs/Tissues associated with anti-ADIPOR1 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >133 publications with ADIPOR1 and Blood
 Adipose Tissue Antibodies  >131 publications with ADIPOR1 and Adipose Tissue
 Muscle Antibodies  >112 publications with ADIPOR1 and Muscle
 Liver Antibodies  >91 publications with ADIPOR1 and Liver
 Connective Tissue Antibodies  >64 publications with ADIPOR1 and Connective Tissue
 Vascular Antibodies  >36 publications with ADIPOR1 and Vascular
 Heart Antibodies  >33 publications with ADIPOR1 and Heart
 Brain Antibodies  >20 publications with ADIPOR1 and Brain
 Embryonic Tissue Antibodies  >14 publications with ADIPOR1 and Embryonic Tissue
 Ovary Antibodies  >14 publications with ADIPOR1 and Ovary
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