Rabbit Anti-MCM2 Polyclonal Antibody – Cat# MBS6319673

Mouse Mcm2 Antibody (C-term) western blot analysis in mouse Neuro-2a cell line lysates (35ug/lane).This demonstrates the Mcm2 antibody detected the Mcm2 protein (arrow).

MCM2 Antibody – Rabbit Polyclonal

Name: MCM2 Antibody; Polyclonal; Rabbit; Mouse-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6319673
Price: 1060 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6319673

Mcm2 acts as a factor that allows the DNA to undergo a single round of replication per cell cycle. Required for the entry in S phase and for cell division. More details

$1060 / 0.2 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Mcm2, Polyclonal Antibody

Full Product Name

Mcm2, CT (Mcm2, Bm28, Cdcl1, Kiaa0030, Mcmd2, DNA replication licensing factor MCM2, Minichromosome maintenance protein 2 homolog, Nuclear protein BM28) (APC)

Product Gene Name

anti-Mcm2 antibody

Product Synonym Names

Mcm2; Bm28; Cdcl1; Kiaa0030; Mcmd2; DNA replication licensing factor MCM2; Minichromosome maintenance protein 2 homolog; Nuclear protein BM28

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Mouse

Form/Format

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).

Purity/Purification

Purified by Protein A Affinity Chromatography.

Preparation and Storage

Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Molecular Weight

102,078 Da

3D Structure

ModBase 3D Structure for P97310

Immunogen

Mouse Mcm2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 711-742 amino acids from the C-terminal region of mouse Mcm2.

Conjugate

APC

Note

Preservative Free

Special Handling

Light sensitive

Product Categories/Family for anti-Mcm2 antibody

Antibodies; Cell Division Cycle (CDC)

Applications Tested/Suitable for anti-Mcm2 antibody

Western Blot (WB), FLISA

Application Notes for anti-Mcm2 antibody

WB: 1:100-500
FLISA: 1:1,000
Applications are based on unconjugated antibody.

Product References and Citations for anti-Mcm2 antibody

Kunnev, D., et al. Oncogene 29(25):3630-3638(2010). Chuang, C.H., et al. PLoS Genet. 6 (9) (2010): Lee, E.Y., et al. Dev. Biol. 332(1):104-115(2009). Hasegawa, M., et al. Leuk. Res. 33(8):1100-1107(2009). Breunig, J.J., et al. Proc. Natl. Acad. Sci. U.S.A. 105(35):13127-13132(2008).

Other Notes

Small volumes of anti-Mcm2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Mcm2 purchase

MBS6319673 is an antibody targeting Mcm2. Also known as Mcm2, CT (Mcm2, Bm28, Cdcl1, Kiaa0030, Mcmd2, DNA replication licensing factor MCM2, Minichromosome maintenance protein 2 homolog, Nuclear protein BM28) (APC). Reactive in Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for Mcm2. It may not necessarily be applicable to this product.

NCBI GI #

172088119

NCBI GeneID

17216

NCBI Accession #

NP_032590.2

UniProt Primary Accession #

P97310

UniProt Secondary Accession #

O08971; O89057; Q8C2R0

UniProt Related Accession #

P97310

GenBank Nucleotide #

NM_008564.2

NCBI Official Full Name

DNA replication licensing factor MCM2

NCBI Official Synonym Full Names

minichromosome maintenance deficient 2 mitotin (S. cerevisiae)

NCBI Official Symbol

Mcm2

NCBI Official Synonym Symbols

BM28; CDCL1; Mcmd2; AA959861; AW476101; mKIAA0030

UniProt Protein Name

DNA replication licensing factor MCM2

UniProt Synonym Protein Names

Minichromosome maintenance protein 2 homolog; Nuclear protein BM28

Protein Family

DNA replication licensing factor

UniProt Gene Name

Mcm2

UniProt Synonym Gene Names

Bm28; Cdcl1; Kiaa0030; Mcmd2

UniProt Entry Name

MCM2_MOUSE

NCBI Protein Information

DNA replication licensing factor MCM2; nuclear protein BM28; mini chromosome maintenance deficient 2; minichromosome maintenance protein 2 homolog

UniProt Comments for Mcm2

MCM2: a mini-chromosome maintenance protein, essential for the initiation of eukaryotic genome replication. Allows DNA to undergo a single round of replication per cell cycle. Required for the entry in S phase and for cell division.

Protein type: EC 3.6.4.12; DNA-binding

Cellular Component: nucleoplasm; microtubule cytoskeleton; MCM complex; cytoplasm; chromatin; nuclear origin of replication recognition complex; nucleus

Molecular Function: DNA helicase activity; DNA binding; hydrolase activity; histone binding; metal ion binding; nucleotide binding; DNA replication origin binding; helicase activity; ATP binding

Biological Process: DNA unwinding during replication; nucleosome assembly; DNA replication initiation; DNA replication; cell cycle

Research Articles on Mcm2

1. Hematopoietic cells originally express higher levels MCM 2 protein and undergo more frequent apoptosis following doxorubicin-induced DNA-damage in the presence of the FLV envelope protein gp70.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-Mcm2 antibody

Products by Pathway	Pathway Diagram
Activation Of ATR In Response To Replication Stress Pathway antibodies	Activation Of ATR In Response To Replication Stress Pathway Diagram
Activation Of The Pre-replicative Complex Pathway antibodies	Activation Of The Pre-replicative Complex Pathway Diagram
Assembly Of The Pre-replicative Complex Pathway antibodies	Assembly Of The Pre-replicative Complex Pathway Diagram
Cell Cycle Pathway antibodies	Cell Cycle Pathway Diagram
Cell Cycle Checkpoints Pathway antibodies	Cell Cycle Checkpoints Pathway Diagram
Cell Cycle, Mitotic Pathway antibodies	Cell Cycle, Mitotic Pathway Diagram
Cell Cycle Pathway antibodies	Cell Cycle Pathway Diagram
Cell Cycle Pathway antibodies	Cell Cycle Pathway Diagram
Cell Cycle Pathway antibodies	Cell Cycle Pathway Diagram
Cell Cycle Signaling Pathway antibodies	Cell Cycle Signaling Pathway Diagram

Diseases associated with anti-Mcm2 antibody

Disease Name	Pubmed Publications
Neoplasms Antibodies	>205 publications with Mcm2 and Neoplasms
Carcinoma Antibodies	>120 publications with Mcm2 and Carcinoma
Adenocarcinoma Antibodies	>53 publications with Mcm2 and Adenocarcinoma
Carcinoma, Squamous Cell Antibodies	>40 publications with Mcm2 and Carcinoma, Squamous Cell
Uterine Neoplasms Antibodies	>26 publications with Mcm2 and Uterine Neoplasms
Uterine Cervical Neoplasms Antibodies	>24 publications with Mcm2 and Uterine Cervical Neoplasms
Precancerous Conditions Antibodies	>23 publications with Mcm2 and Precancerous Conditions
Chromosome Aberrations Antibodies	>22 publications with Mcm2 and Chromosome Aberrations
Nervous System Diseases Antibodies	>19 publications with Mcm2 and Nervous System Diseases
Breast Neoplasms Antibodies	>16 publications with Mcm2 and Breast Neoplasms

Organs/Tissues associated with anti-Mcm2 antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>26 publications with Mcm2 and Brain
Blood Antibodies	>20 publications with Mcm2 and Blood
Lymph Node Antibodies	>20 publications with Mcm2 and Lymph Node
Lung Antibodies	>19 publications with Mcm2 and Lung
Liver Antibodies	>14 publications with Mcm2 and Liver
Bone Antibodies	>13 publications with Mcm2 and Bone
Prostate Antibodies	>10 publications with Mcm2 and Prostate
Intestine Antibodies	>10 publications with Mcm2 and Intestine
Kidney Antibodies	>10 publications with Mcm2 and Kidney
Skin Antibodies	>9 publications with Mcm2 and Skin