NT5C2 Recombinant Protein – Cat# MBS636839

SDS: Analysis of NT5C2 Recombinant Protein. 4-20% SDS gradient gel. Coomassie blue staining.

5'-Nucleotidase, Cytosolic II (NT5C2) Recombinant Protein

Name: NT5C2 Recombinant Protein; MyBioSource
Brand: MyBioSource
SKU: MBS636839
Price: 495 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS636839

Purine 5-prime-nucleotidase (EC 3.1.3.5) preferentially hydrolyzes inosine 5-prime-monophosphate (IMP) and other purine nucleotides, and is allosterically activated by various compounds, including ATP. The enzyme is exclusively located in the cytoplasmic… More details

$495 / 0.05 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

5'-Nucleotidase, Cytosolic II (NT5C2), Recombinant Protein

Full Product Name

5'-Nucleotidase, Cytosolic II (NT5B) Recombinant, Human

Product Gene Name

NT5C2 recombinant protein

Form/Format

Supplied as a liquid in 10mM Tris, pH 8.0, 0.1% Triton X-100, 0.002% sodium azide, 10mM DTT.

Purity/Purification

Highly Purified
Highly purified (95%).

Preparation and Storage

May be stored at 4 degree C for short-term only. For long-term storage, aliquot to avoid repeated freezing and thawing and freeze at -70 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquots are stable for at least 12 months.

Molecular Weight

64,970 Da

Chromosome Location

Chromosome: 10; NC_000010.10 (104847774..104953063, complement). Location: 10q24.32

OMIM

600417

3D Structure

ModBase 3D Structure for P49902

Quality Control

SDS-PAGE

Product Categories/Family for NT5C2 recombinant protein

Molecular Biology; MB-Enzymes; Nucleotidase

Applications Tested/Suitable for NT5C2 recombinant protein

ELISA (EL/EIA), Western Blot (WB)

Application Notes for NT5C2 recombinant protein

Suitable for use in Suitable for use in ELISA and Western Blot (64.5kD).

Other Notes

Small volumes of NT5C2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NT5C2 purchase

MBS636839 is a recombinant protein targeting NT5C2. Also known as 5'-Nucleotidase, Cytosolic II (NT5B) Recombinant, Human.

Additional Details

NCBI/Uniprot data below describe general gene information for NT5C2. It may not necessarily be applicable to this product.

NCBI GI #

12804389

NCBI GeneID

22978

NCBI Accession #

AAH01595.1

UniProt Primary Accession #

P49902

UniProt Secondary Accession #

Q5JUV5; D3DR91

UniProt Related Accession #

P49902

NCBI Official Full Name

5'-nucleotidase, cytosolic II

NCBI Official Synonym Full Names

5'-nucleotidase, cytosolic II

NCBI Official Symbol

NT5C2

NCBI Official Synonym Symbols

GMP; NT5B; PNT5; cN-II

UniProt Protein Name

Cytosolic purine 5'-nucleotidase

UniProt Synonym Protein Names

Cytosolic 5'-nucleotidase II

Protein Family

Cytosolic purine 5'-nucleotidase

UniProt Gene Name

NT5C2

UniProt Synonym Gene Names

NT5B; NT5CP; PNT5

UniProt Entry Name

5NTC_HUMAN

NCBI Protein Information

cytosolic purine 5'-nucleotidase; IMP-specific 5'-NT; purine 5' nucleotidase; cytosolic 5'-nucleotidase II; 5'-nucleotidase (purine), cytosolic type B

NCBI Summary for NT5C2

This gene encodes a hydrolase that serves as an important role in cellular purine metabolism by acting primarily on inosine 5'-monophosphate and other purine nucleotides. [provided by RefSeq, Oct 2011]

UniProt Comments for NT5C2

NT5C2: May have a critical role in the maintenance of a constant composition of intracellular purine/pyrimidine nucleotides in cooperation with other nucleotidases. Preferentially hydrolyzes inosine 5'-monophosphate (IMP) and other purine nucleotides. Belongs to the 5'(3')-deoxyribonucleotidase family.

Protein type: Cofactor and Vitamin Metabolism - nicotinate and nicotinamide; Nucleotide Metabolism - pyrimidine; Nucleotide Metabolism - purine; EC 3.1.3.5; Hydrolase

Chromosomal Location of Human Ortholog: 10q24.32

Cellular Component: cytosol

Molecular Function: 5'-nucleotidase activity; protein binding; metal ion binding; nucleoside phosphotransferase activity; nucleotide binding

Biological Process: dephosphorylation; nucleobase, nucleoside and nucleotide metabolic process; IMP metabolic process; purine nucleotide catabolic process; drug metabolic process; adenosine metabolic process; phosphorylation; purine base metabolic process

Research Articles on NT5C2

1. These results suggest that mutations in NT5C2 are associated with the outgrowth of drug-resistant clones in acute lymphoblastic leukemia

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with NT5C2 recombinant protein

Reference Product	PubMed Publications
DCK recombinant protein	>7 publications with NT5C2 and DCK
CDA recombinant protein	>3 publications with NT5C2 and CDA
DCTD recombinant protein	>1 publications with NT5C2 and DCTD

Pathways associated with NT5C2 recombinant protein

Products by Pathway	Pathway Diagram
Abacavir Metabolism Pathway antibodies	Abacavir Metabolism Pathway Diagram
Abacavir Transport And Metabolism Pathway antibodies	Abacavir Transport And Metabolism Pathway Diagram
Metabolism Pathway antibodies	Metabolism Pathway Diagram
Metabolism Of Nucleotides Pathway antibodies	Metabolism Of Nucleotides Pathway Diagram
Nicotinate And Nicotinamide Metabolism Pathway antibodies	Nicotinate And Nicotinamide Metabolism Pathway Diagram
Nicotinate And Nicotinamide Metabolism Pathway antibodies	Nicotinate And Nicotinamide Metabolism Pathway Diagram
Purine Catabolism Pathway antibodies	Purine Catabolism Pathway Diagram
Purine Metabolism Pathway antibodies	Purine Metabolism Pathway Diagram
Purine Metabolism Pathway antibodies	Purine Metabolism Pathway Diagram
Purine Metabolism Pathway antibodies	Purine Metabolism Pathway Diagram

Diseases associated with NT5C2 recombinant protein

Disease Name	Pubmed Publications
Neoplasms Antibodies	>15 publications with NT5C2 and Neoplasms
Immune System Diseases Antibodies	>3 publications with NT5C2 and Immune System Diseases
Precursor Cell Lymphoblastic Leukemia-Lymphoma Antibodies	>3 publications with NT5C2 and Precursor Cell Lymphoblastic Leukemia-Lymphoma
Neoplasms, Experimental Antibodies	>2 publications with NT5C2 and Neoplasms, Experimental
Recurrence Antibodies	>2 publications with NT5C2 and Recurrence
Disease Models, Animal Antibodies	>1 publications with NT5C2 and Disease Models, Animal
Weight Loss Antibodies	>1 publications with NT5C2 and Weight Loss
Liver Neoplasms Antibodies	>1 publications with NT5C2 and Liver Neoplasms
Nervous System Diseases Antibodies	>1 publications with NT5C2 and Nervous System Diseases
Precancerous Conditions Antibodies	>1 publications with NT5C2 and Precancerous Conditions

Organs/Tissues associated with NT5C2 recombinant protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>8 publications with NT5C2 and Blood
Bone Marrow Antibodies	>3 publications with NT5C2 and Bone Marrow
Bone Antibodies	>3 publications with NT5C2 and Bone
Lung Antibodies	>2 publications with NT5C2 and Lung
Brain Antibodies	>2 publications with NT5C2 and Brain
Adipose Tissue Antibodies	>1 publications with NT5C2 and Adipose Tissue
Liver Antibodies	>1 publications with NT5C2 and Liver
Muscle Antibodies	>1 publications with NT5C2 and Muscle
Vascular Antibodies	>1 publications with NT5C2 and Vascular
Connective Tissue Antibodies	>1 publications with NT5C2 and Connective Tissue