PELI1 Antibody – Rabbit Polyclonal

Function: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates 'Lys-63'-linked polyubiquitination of IRAK1 allowing subsequent NF-kappa-B activation. Ref.6 Ref.9

Pathway: Protein modification; protein ubiquitination.

Subunit structure: Interacts with MAP3K7. Upon IL1B treatment, forms a complex with TRAF6, IRAK1, IRAK4 and MYD88; this complex recruits MAP3K7/TAK1, TAB1 and TAB2 to mediate NF-kappa-B activation. Direct binding of SMAD6 to PELI1 prevents the complex formation and hence negatively regulates IL1R-TLR signaling and eventually NF-kappa-B-mediated gene expression. Ref.6 Ref.7 Ref.8

Post-translational modification: Phosphorylation by IRAK1 and IRAK4 enhances its E3 ligase activity.Sumoylated. Ref.11

Sequence similarities: Belongs to the pellino family.

Sequence caution: The sequence AAH11419.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence BAB55280.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.