Rat Anti-IL7 Monoclonal Antibody – Cat# MBS670048

Standard curve generated with Rat Anti-Human IL-7-UNLB (MBS670048; Clone BVD10-40F6) and Rat Anti-Human IL-7-BIOT (MBS670051; Clone BVD10-11C10) followed by Mouse Anti-BIOT-HRP (MBS675023)

Il-7 (IL7) Antibody – Rat Monoclonal

Name: IL7 Antibody; Monoclonal; Rat; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS670048
Price: 405 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS670048

MBS670048 is an antibody targeting IL7. Also known as Rat Anti-Human IL-7-UNLB. Reactive in Human. Host: Rat. More details

$405 / 0.5 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

IL-7 (IL7), Monoclonal Antibody

Full Product Name

Rat Anti-Human IL-7-UNLB

Product Gene Name

anti-IL7 antibody

Product Synonym Names

Rat Anti-Human IL-7 - Purified, Unlabeled Antibody; Rat Anti-Human IL-7

Clonality

Monoclonal

Isotype

Rat IgG1 kappa

Clone Number

BVD10-40F6

Host

Rat

Species Reactivity

Human

Form/Format

Purified (UNLB) Antibody

Specificity

Human IL-7

Preparation and Storage

The purified (UNLB) antibody is supplied as 0.5 mg purified immunoglobulin in 1.0 mL of borate buffered saline, pH 8.2. No preservatives or amine-containing buffered salts added.
Store at 2-8°C.

Chromosome Location

Chromosome: 8; NC_000008.10 (79645005..79717758, complement). Location: 8q12-q13

OMIM

146660

3D Structure

ModBase 3D Structure for P13232

Immunogen

E. coli-expressed recombinant human IL-7

Characterization

To ensure acceptable performance, each batch of product is tested in a sandwich ELISA to conform to characteristics of a standard reference reagent.

Applications Tested/Suitable for anti-IL7 antibody

ELISA-Capture – Quality tested^1-3
Immunocytochemistry – Reported in literature ⁴
Neutralization – Reported in literature ^1,5

Note – May be paired with the biotinylated clone BVD10-11C10 (MB

Application Notes for anti-IL7 antibody

ELISA - Purified (UNLB) antibody: <=5 ug/ml

Since applications vary, you should determine the optimum working dilution for the product that is apprpriate for your specific need.

Product References and Citations for anti-IL7 antibody

1. Abrams, J.S., M.-G. Roncarolo, H.. Yssel, U. Andersson, G.J. Gleich, and J.E., Silver. 1992. Immunol. Rev. 127:5.
2. Abrams, J. 1995. Immunoenzymetric assay of mouse and human cytokines using NIP-labeled anti-cytokine antibodies. In Current Protocols in Immunology (J. Coligamn, A. Kruisbeek, D. Margulies, E. Shevach, W. Strober, eds.). John Wiley and Sons, New York. Unit 6.20.

Other Notes

Small volumes of anti-IL7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for IL7. It may not necessarily be applicable to this product.

NCBI GI #

4504677

NCBI GeneID

3574

NCBI Accession #

NP_000871.1

UniProt Primary Accession #

P13232

UniProt Secondary Accession #

A0N0L3

UniProt Related Accession #

P13232; Q5FBX5; Q5FBY3; Q5FBY5; Q5FBY6; Q5FBY8; Q5FBY9

GenBank Nucleotide #

NM_000880.3

NCBI Official Full Name

interleukin-7 isoform 1

NCBI Official Synonym Full Names

interleukin 7

NCBI Official Symbol

IL7

NCBI Official Synonym Symbols

IL-7

UniProt Protein Name

Interleukin-7

Protein Family

Interleukin

UniProt Gene Name

IL7

UniProt Entry Name

IL7_HUMAN

NCBI Protein Information

interleukin-7; OTTHUMP00000227044; OTTHUMP00000227046

NCBI Summary for IL7

The protein encoded by this gene is a cytokine important for B and T cell development. This cytokine and the hepatocyte growth factor (HGF) form a heterodimer that functions as a pre-pro-B cell growth-stimulating factor. This cytokine is found to be a cofactor for V(D)J rearrangement of the T cell receptor beta (TCRB) during early T cell development. This cytokine can be produced locally by intestinal epithelial and epithelial goblet cells, and may serve as a regulatory factor for intestinal mucosal lymphocytes. Knockout studies in mice suggested that this cytokine plays an essential role in lymphoid cell survival. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their presence in normal tissues has not been confirmed.

UniProt Comments for IL7

Function: Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation.

Subcellular location: Secreted.

Sequence similarities: Belongs to the IL-7/IL-9 family.

Research Articles on IL7

1. immunological nonresponders to HIV therapy display elevated BM IL-7/IL-7Ralpha expression but impaired T-cell responsiveness to IL-7, suggesting the activity of a central compensatory pathway targeted to replenish the CD4+ compartment

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-IL7 antibody

Reference Product	PubMed Publications
IL7R antibody	>7 publications with IL7 and IL7R
IL2RG antibody	>7 publications with IL7 and IL2RG

Pathways associated with anti-IL7 antibody

Products by Pathway	Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Hematopoietic Cell Lineage Pathway antibodies	Hematopoietic Cell Lineage Pathway Diagram
Hematopoietic Cell Lineage Pathway antibodies	Hematopoietic Cell Lineage Pathway Diagram
Jak-STAT Signaling Pathway antibodies	Jak-STAT Signaling Pathway Diagram
Jak-STAT Signaling Pathway antibodies	Jak-STAT Signaling Pathway Diagram

Diseases associated with anti-IL7 antibody

Disease Name	Pubmed Publications
Neoplasms Antibodies	>42 publications with IL7 and Neoplasms
Lymphoma Antibodies	>18 publications with IL7 and Lymphoma
Neoplasms, Experimental Antibodies	>14 publications with IL7 and Neoplasms, Experimental
Lymphoma, T-Cell Antibodies	>13 publications with IL7 and Lymphoma, T-Cell
Lymphopenia Antibodies	>13 publications with IL7 and Lymphopenia
Inflammation Antibodies	>12 publications with IL7 and Inflammation
Multiple Sclerosis Antibodies	>12 publications with IL7 and Multiple Sclerosis
Demyelinating Diseases Antibodies	>11 publications with IL7 and Demyelinating Diseases
Leukemia, Myeloid, Acute Antibodies	>5 publications with IL7 and Leukemia, Myeloid, Acute
Carcinoma Antibodies	>5 publications with IL7 and Carcinoma

Organs/Tissues associated with anti-IL7 antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>136 publications with IL7 and Blood
Bone Antibodies	>36 publications with IL7 and Bone
Thymus Antibodies	>33 publications with IL7 and Thymus
Lymph Node Antibodies	>15 publications with IL7 and Lymph Node
Skin Antibodies	>11 publications with IL7 and Skin
Spleen Antibodies	>10 publications with IL7 and Spleen
Liver Antibodies	>9 publications with IL7 and Liver
Intestine Antibodies	>5 publications with IL7 and Intestine
Brain Antibodies	>4 publications with IL7 and Brain
Kidney Antibodies	>2 publications with IL7 and Kidney