Mouse Anti-ADAM-8 Monoclonal Antibody – Cat# MBS690844

ADAM-8 Antibody – Mouse Monoclonal

Name: ADAM-8 Antibody; Monoclonal; Mouse; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS690844
Price: 875 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS690844

ADAM8, also known as cell surface antigen MS2 or CD156a, is a member of the ADAM family that contains a disintegrin and metalloprotease-like domain. ADAM8 can cleave a variety of substrates and has been shown as a sheddase for the low affinity IgE receptor… More details

DISCONTINUED
Click here to view our similar product(s) OR click here to contact our technical support team for suitable replacement.

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

ADAM-8, Monoclonal Antibody

Full Product Name

Mouse Anti-Human ADAM-8

Product Gene Name

anti-ADAM-8 antibody

Product Synonym Names

ADAM8; MS2; CD156

Clonality

Monoclonal

Isotype

IgG1

Clone Number

(6J12)

Host

Mouse

Species Reactivity

Human

Form/Format

Lyophilized

Preparation and Storage

Lyophilized samples are stable for 2 years from date of receipt when stored at -70 degree C. Reconstituted antibody can be aliquoted and stored frozen at < -20 degree C for at least for six months without detectable loss of activity.

Molecular Weight

88,771 Da

Chromosome Location

Chromosome: 10; NC_000010.11 (133262416..133276903, complement). Location: 10q26.3

OMIM

602267

3D Structure

ModBase 3D Structure for P78325

Antibody Generation

This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with Human ADAM-8 (extracellular domain) recombinant protein.

Reconstitution

Reconstitute the antibody with 200 ul sterile PBS and the final concentration is 500 ug/ml.

ISO Certification

Manufactured in an ISO 9001:2008 Certified Laboratory.

Applications Tested/Suitable for anti-ADAM-8 antibody

Western Blot (WB)

Other Notes

Small volumes of anti-ADAM-8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ADAM-8 purchase

MBS690844 is an antibody targeting ADAM-8. Also known as Mouse Anti-Human ADAM-8. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for ADAM-8. It may not necessarily be applicable to this product.

NCBI GI #

256773264

NCBI GeneID

101

NCBI Accession #

NP_001100.3

UniProt Primary Accession #

P78325

UniProt Secondary Accession #

B4DVM6; H0YL36; H0YLR0; H0YN39

UniProt Related Accession #

P78325

GenBank Nucleotide #

NM_001109.4

NCBI Official Full Name

disintegrin and metalloproteinase domain-containing protein 8 isoform 1

NCBI Official Synonym Full Names

ADAM metallopeptidase domain 8

NCBI Official Symbol

ADAM8

NCBI Official Synonym Symbols

MS2; CD156

UniProt Protein Name

Disintegrin and metalloproteinase domain-containing protein 8

UniProt Synonym Protein Names

Cell surface antigen MS2

Protein Family

Disintegrin and metalloproteinase domain-containing protein

UniProt Gene Name

ADAM8

UniProt Synonym Gene Names

MS2; ADAM 8

UniProt Entry Name

ADAM8_HUMAN

NCBI Protein Information

disintegrin and metalloproteinase domain-containing protein 8; cell surface antigen MS2; human leukocyte differentiation antigen; a disintegrin and metalloproteinase domain 8

NCBI Summary for ADAM-8

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene may be involved in cell adhesion during neurodegeneration, and it is thought to be a target for allergic respiratory diseases, including asthma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2009]

UniProt Comments for ADAM-8

Function: Possible involvement in extravasation of leukocytes.

Cofactor: Binds 1 zinc ion per subunit.

Subunit structure: Interacts with FST3. Ref.5

Subcellular location: Membrane; Single-pass type I membrane protein.

Tissue specificity: Expressed on neutrophils and monocytes.

Sequence similarities: Contains 1 disintegrin domain.Contains 1 EGF-like domain.Contains 1 peptidase M12B domain.

Research Articles on ADAM-8

1. ADAM8 was highly expressed in 54.3% of hepatocellular carcinoma patients. ADAM8 expression was closely associated with tumor size, histological differentiation, recurrence, metastasis, and stage. High levels of ADAM8 resulted in poor prognosis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-ADAM-8 antibody

Products by Pathway	Pathway Diagram
Degradation Of The Extracellular Matrix Pathway antibodies	Degradation Of The Extracellular Matrix Pathway Diagram
Extracellular Matrix Organization Pathway antibodies	Extracellular Matrix Organization Pathway Diagram

Diseases associated with anti-ADAM-8 antibody

Disease Name	Pubmed Publications
Inflammation Antibodies	>36 publications with ADAM-8 and Inflammation
Neoplasms Antibodies	>30 publications with ADAM-8 and Neoplasms
Necrosis Antibodies	>17 publications with ADAM-8 and Necrosis
Disease Models, Animal Antibodies	>11 publications with ADAM-8 and Disease Models, Animal
Cardiovascular Diseases Antibodies	>8 publications with ADAM-8 and Cardiovascular Diseases
Liver Diseases Antibodies	>6 publications with ADAM-8 and Liver Diseases
Lung Neoplasms Antibodies	>6 publications with ADAM-8 and Lung Neoplasms
Carcinoma, Squamous Cell Antibodies	>6 publications with ADAM-8 and Carcinoma, Squamous Cell
Liver Neoplasms Antibodies	>5 publications with ADAM-8 and Liver Neoplasms
Neoplasms, Experimental Antibodies	>4 publications with ADAM-8 and Neoplasms, Experimental

Organs/Tissues associated with anti-ADAM-8 antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>40 publications with ADAM-8 and Blood
Lung Antibodies	>21 publications with ADAM-8 and Lung
Brain Antibodies	>15 publications with ADAM-8 and Brain
Connective Tissue Antibodies	>7 publications with ADAM-8 and Connective Tissue
Bone Marrow Antibodies	>6 publications with ADAM-8 and Bone Marrow
Stomach Antibodies	>5 publications with ADAM-8 and Stomach
Kidney Antibodies	>5 publications with ADAM-8 and Kidney
Eye Antibodies	>2 publications with ADAM-8 and Eye
Spleen Antibodies	>2 publications with ADAM-8 and Spleen
Prostate Antibodies	>2 publications with ADAM-8 and Prostate