Histocompatibility (Minor) 13 (HM13) Antibody – Rabbit Polyclonal

The protein encoded by this gene, which localizes to the endoplasmic reticulum, catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein. This activity is required to generate signal sequence-derived human lymphocyte antigen-E epitopes that are recognized by the immune system, and to process hepatitis C virus core protein. The encoded protein is an integral membrane protein with sequence motifs characteristic of the presenilin-type aspartic proteases. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

HM13: Catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein, resulting in the release of the fragment from the ER membrane into the cytoplasm. Required to generate lymphocyte cell surface (HLA-E) epitopes derived from MHC class I signal peptides. May play a role in graft rejection. May be necessary for the removal of the signal peptide that remains attached to the hepatitis C virus core protein after the initial proteolytic processing of the polyprotein. Involved in the intramembrane cleavage of the integral membrane protein PSEN1. Belongs to the peptidase A22B family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; EC 3.4.23.-; Endoplasmic reticulum; Protease

Chromosomal Location of Human Ortholog: 20q11.21

Cellular Component: cell surface; membrane; rough endoplasmic reticulum; endoplasmic reticulum; plasma membrane

Molecular Function: peptidase activity; protein binding; protein homodimerization activity; ubiquitin protein ligase binding; aspartic endopeptidase activity, intramembrane cleaving

Biological Process: membrane protein intracellular domain proteolysis; membrane protein proteolysis; membrane protein ectodomain proteolysis