Rabbit Anti-GOT2 Polyclonal Antibody – Cat# MBS715263

Aspartate Aminotransferase (GOT2) Antibody – Rabbit Polyclonal

Name: GOT2 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS715263
Price: 230 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS715263

Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids. More details

$230 / 0.05 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Aspartate aminotransferase (GOT2), Polyclonal Antibody

Full Product Name

Rabbit anti- human Aspartate aminotransferase, mitochondrial polyclonal Antibody, HRP conjugated

Product Gene Name

anti-GOT2 antibody

Product Synonym Names

GOT2; Fatty acid-binding protein; FABP-1; Glutamate oxaloacetate transaminase 2; Plasma membrane-associated fatty acid-binding protein; FABPpm; Transaminase A

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Purity/Purification

Caprylic Acid Ammonium Sulfate Precipitation Purified

Preparation and Storage

Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

Matching Pairs

Unconjugated Antibody: Aspartate aminotransferase, mitochondrial (MBS7006066)
HRP Conjugated Antibody: Aspartate aminotransferase (MBS715263)

Molecular Weight

43,030 Da

OMIM

138150

3D Structure

ModBase 3D Structure for P00505

Storage Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Conjugate

HRP

Immunogen

Recombinant human Aspartate aminotransferase, mitochondrial protein

Santa Cruz Alternative

Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-46707 / sc-46704

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Applications Tested/Suitable for anti-GOT2 antibody

ELISA (EIA)

Other Notes

Small volumes of anti-GOT2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GOT2 purchase

MBS715263 is an antibody targeting GOT2. Also known as Rabbit anti- human Aspartate aminotransferase, mitochondrial polyclonal Antibody, HRP conjugated. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for GOT2. It may not necessarily be applicable to this product.

NCBI GI #

555290167

NCBI GeneID

2806

NCBI Accession #

NP_001273149.1

UniProt Primary Accession #

P00505

UniProt Secondary Accession #

Q53FL3; Q9BWA3; B4DJA6; E7ERW2

UniProt Related Accession #

P00505

GenBank Nucleotide #

NM_001286220.1

NCBI Official Full Name

aspartate aminotransferase, mitochondrial isoform 2

NCBI Official Synonym Full Names

glutamic-oxaloacetic transaminase 2

NCBI Official Symbol

GOT2

NCBI Official Synonym Symbols

KAT4; KATIV; mitAAT

UniProt Protein Name

Aspartate aminotransferase, mitochondrial

UniProt Synonym Protein Names

Fatty acid-binding protein; FABP-1; Glutamate oxaloacetate transaminase 2; Kynurenine aminotransferase 4; Kynurenine aminotransferase IV; Kynurenine--oxoglutarate transaminase 4; Kynurenine--oxoglutarate transaminase IV; Plasma membrane-associated fatty acid-binding protein; FABPpm; Transaminase A

Protein Family

Aspartate aminotransferase

UniProt Gene Name

GOT2

UniProt Synonym Gene Names

mAspAT; FABP-1; FABPpm

UniProt Entry Name

AATM_HUMAN

NCBI Protein Information

aspartate aminotransferase, mitochondrial

NCBI Summary for GOT2

Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic and inner-membrane mitochondrial forms, GOT1 and GOT2, respectively. GOT plays a role in amino acid metabolism and the urea and tricarboxylic acid cycles. The two enzymes are homodimeric and show close homology. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2013]

UniProt Comments for GOT2

GOT2: Catalyzes the irreversible transamination of the L- tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids. Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

Protein type: Amino Acid Metabolism - arginine and proline; Amino Acid Metabolism - phenylalanine, tyrosine and tryptophan biosynthesis; Transferase; Amino Acid Metabolism - alanine, aspartate and glutamate; EC 2.6.1.1; Amino Acid Metabolism - phenylalanine; Amino Acid Metabolism - cysteine and methionine; Amino Acid Metabolism - tyrosine; EC 2.6.1.7; Mitochondrial

Chromosomal Location of Human Ortholog: 16q21

Cellular Component: cell surface; mitochondrial inner membrane; mitochondrial matrix; mitochondrion; myelin sheath; perikaryon; plasma membrane; protein complex

Molecular Function: amino acid binding; aspartate transaminase activity; enzyme binding; identical protein binding; kynurenine-oxoglutarate transaminase activity; phospholipid binding; protein homodimerization activity; pyridoxal phosphate binding

Biological Process: 2-oxoglutarate metabolic process; 4-hydroxyproline catabolic process; amino acid biosynthetic process; aspartate biosynthetic process; aspartate catabolic process; aspartate metabolic process; carbohydrate metabolic process; fatty acid transport; gluconeogenesis; glucose metabolic process; glutamate catabolic process to 2-oxoglutarate; glutamate catabolic process to aspartate; glutamate metabolic process; oxaloacetate metabolic process; response to ethanol

Research Articles on GOT2

1. A previously unknown mechanism by which GOT2 acetylation stimulates the malate-aspartate NADH shuttle activity and oxidative protection.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-GOT2 antibody

Reference Product	PubMed Publications
MDH2 antibody	>5 publications with GOT2 and MDH2
MDH1 antibody	>3 publications with GOT2 and MDH1
TAT antibody	>2 publications with GOT2 and TAT

Pathways associated with anti-GOT2 antibody

Products by Pathway	Pathway Diagram
2-Oxocarboxylic Acid Metabolism Pathway antibodies	2-Oxocarboxylic Acid Metabolism Pathway Diagram
2-Oxocarboxylic Acid Metabolism Pathway antibodies	2-Oxocarboxylic Acid Metabolism Pathway Diagram
4-hydroxyproline Degradation Pathway antibodies	4-hydroxyproline Degradation Pathway Diagram
Alanine And Aspartate Metabolism Pathway antibodies	Alanine And Aspartate Metabolism Pathway Diagram
Alanine, Aspartate And Glutamate Metabolism Pathway antibodies	Alanine, Aspartate And Glutamate Metabolism Pathway Diagram
Alanine, Aspartate And Glutamate Metabolism Pathway antibodies	Alanine, Aspartate And Glutamate Metabolism Pathway Diagram
Amino Acid Synthesis And Interconversion (transamination) Pathway antibodies	Amino Acid Synthesis And Interconversion (transamination) Pathway Diagram
Arginine And Proline Metabolism Pathway antibodies	Arginine And Proline Metabolism Pathway Diagram
Arginine And Proline Metabolism Pathway antibodies	Arginine And Proline Metabolism Pathway Diagram
Arginine Biosynthesis Pathway antibodies	Arginine Biosynthesis Pathway Diagram

Diseases associated with anti-GOT2 antibody

Disease Name	Pubmed Publications
Disease Models, Animal Antibodies	>4 publications with GOT2 and Disease Models, Animal
Cardiovascular Diseases Antibodies	>4 publications with GOT2 and Cardiovascular Diseases
Mental Disorders Antibodies	>2 publications with GOT2 and Mental Disorders
Liver Diseases Antibodies	>2 publications with GOT2 and Liver Diseases
Nervous System Diseases Antibodies	>2 publications with GOT2 and Nervous System Diseases
Fatty Liver Antibodies	>2 publications with GOT2 and Fatty Liver
Hypertension Antibodies	>2 publications with GOT2 and Hypertension
Cardiomyopathies Antibodies	>1 publications with GOT2 and Cardiomyopathies
Weight Loss Antibodies	>1 publications with GOT2 and Weight Loss
Hypertrophy Antibodies	>1 publications with GOT2 and Hypertrophy

Organs/Tissues associated with anti-GOT2 antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>8 publications with GOT2 and Blood
Liver Antibodies	>5 publications with GOT2 and Liver
Thyroid Antibodies	>3 publications with GOT2 and Thyroid
Muscle Antibodies	>3 publications with GOT2 and Muscle
Brain Antibodies	>3 publications with GOT2 and Brain
Vascular Antibodies	>2 publications with GOT2 and Vascular
Heart Antibodies	>2 publications with GOT2 and Heart
Bladder Antibodies	>2 publications with GOT2 and Bladder
Adrenal Gland Antibodies	>1 publications with GOT2 and Adrenal Gland
Intestine Antibodies	>1 publications with GOT2 and Intestine