Tenascin (TNC) Antibody – Rabbit Polyclonal

This gene encodes an extracellular matrix protein with a spatially and temporally restricted tissue distribution. This protein is homohexameric with disulfide-linked subunits, and contains multiple EGF-like and fibronectin type-III domains. It is implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity, and neuronal regeneration. [provided by RefSeq, Jul 2011]

TNC: Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6. Belongs to the tenascin family. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 9q33

Cellular Component: basement membrane; extracellular matrix; extracellular region; extracellular space; focal adhesion; membrane

Molecular Function: syndecan binding

Biological Process: axon regeneration in the peripheral nervous system; cell adhesion; extracellular matrix organization and biogenesis; negative regulation of cell adhesion; neuromuscular junction development; odontogenesis of dentine-containing teeth; osteoblast differentiation; positive regulation of cell proliferation; response to ethanol; response to mechanical stimulus; response to wounding; wound healing

Disease: Deafness, Autosomal Dominant 56