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AHCY Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9410957

S-adenosylhomocysteine hydrolase belongs to the adenosylhomocysteinase family. It catalyzes the reversible hydrolysis of S-adenosylhomocysteine (AdoHcy) to adenosine (Ado) and L-homocysteine (Hcy). Thus, it regulates the intracellular S-adenosylhomocysteine… More details

$320 / 0.05 mL +1 FREE 8GB USB
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
AHCY, Polyclonal Antibody
Full Product Name
AHCY Antibody
Product Gene Name
anti-AHCY antibody
Product Synonym Names
SAHH; adoHcyase
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity/Purification
Antibodies were purified by affinity purification using immunogen.
Concentration
1.0 mg/ml (lot specific)
Specificity
The antibody detects endogenous level of total AHCY protein.
Preparation and Storage
Store at -20 degree C
Molecular Weight
44,659 Da
OMIM
180960
3D Structure
ModBase 3D Structure for P23526
Immunogen Type
Recombinant Protein
Immunogen Description
Recombinant protein of human AHCY.
Target Name
AHCY

Product Categories/Family for anti-AHCY antibody

Total protein Ab
Applications Tested/Suitable for anti-AHCY antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-AHCY antibody
Western blotting: 1:500 - 1:2000
Immunohistochemistry: 1:50 - 1:200

Western Blot (WB) of anti-AHCY antibody

Western blot analysis of extracts of various cell lines, using AHCY antibody.
Rabbit Anti-AHCY Polyclonal Antibody – Cat# MBS9410957

Immunohistochemistry (IHC) of anti-AHCY antibody

Immunohistochemical analysis of paraffin-embedded human lung using AHCY antibody at dilution of 1:200 (200x lens).
Rabbit Anti-AHCY Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS9410957

Immunohistochemistry (IHC) of anti-AHCY antibody

Immunohistochemical analysis of paraffin-embedded human breast cancer using AHCY antibody at dilution of 1:200 (200x lens).
Rabbit Anti-AHCY Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS9410957

Other Notes

Small volumes of anti-AHCY antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for AHCY purchase

MBS9410957 is an antibody targeting AHCY. Also known as AHCY Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for AHCY. It may not necessarily be applicable to this product.

NCBI GI #
9951915
NCBI GeneID
191
NCBI Accession #
NP_000678.1
UniProt Primary Accession #
P23526
UniProt Secondary Accession #
Q96A36; A8K307; B3KUN3; E1P5P2; F5H737
UniProt Related Accession #
P23526
GenBank Nucleotide #
NM_000687.2
NCBI Official Full Name
adenosylhomocysteinase isoform 1
NCBI Official Synonym Full Names
adenosylhomocysteinase
NCBI Official Symbol
AHCY
NCBI Official Synonym Symbols
SAHH; adoHcyase
UniProt Protein Name
Adenosylhomocysteinase
UniProt Synonym Protein Names
S-adenosyl-L-homocysteine hydrolase
Protein Family
Adenosylhomocysteinase
UniProt Gene Name
AHCY
UniProt Synonym Gene Names
SAHH; AdoHcyase
UniProt Entry Name
SAHH_HUMAN
NCBI Protein Information
adenosylhomocysteinase

UniProt Comments for AHCY

SAHH: Adenosylhomocysteine is a competitive inhibitor of S- adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine. Defects in AHCY are the cause of hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD). A metabolic disorder characterized by hypermethioninemia associated with failure to thrive, mental and motor retardation, facial dysmorphism with abnormal hair and teeth, and myocardiopathy. Belongs to the adenosylhomocysteinase family.

Protein type: Hydrolase; EC 3.3.1.1; Other Amino Acids Metabolism - selenoamino acid; Amino Acid Metabolism - cysteine and methionine

Chromosomal Location of Human Ortholog: 20q11.22

Cellular Component: neuron projection; cytoplasm; melanosome; cytosol; nucleus

Molecular Function: identical protein binding; adenyl nucleotide binding; adenosylhomocysteinase activity

Biological Process: methylation; circadian sleep/wake cycle; S-adenosylmethionine cycle; sulfur amino acid metabolic process; xenobiotic metabolic process; response to hypoxia; S-adenosylhomocysteine catabolic process; one-carbon compound metabolic process; chronic inflammatory response to antigenic stimulus; response to nutrient

Disease: Hypermethioninemia With S-adenosylhomocysteine Hydrolase Deficiency
Show more

Research Articles on AHCY

1. S-adenosylhomocysteine hydrolase is regulated by lysine acetylation

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-AHCY antibody

 Reference Product  PubMed Publications
 CBS antibody  >9 publications with AHCY and CBS
 MAT1A antibody  >8 publications with AHCY and MAT1A
 BHMT antibody  >7 publications with AHCY and BHMT
 MAT2A antibody  >5 publications with AHCY and MAT2A
 MTRR antibody  >4 publications with AHCY and MTRR
 MTR antibody  >4 publications with AHCY and MTR
 DNMT1 antibody  >3 publications with AHCY and DNMT1
 CTH antibody  >1 publications with AHCY and CTH

Pathways associated with anti-AHCY antibody

 Products by Pathway  Pathway Diagram
 Biological Oxidations Pathway antibodies  Biological Oxidations Pathway Diagram
 Cysteine And Methionine Metabolism Pathway antibodies  Cysteine And Methionine Metabolism Pathway Diagram
 Cysteine And Methionine Metabolism Pathway antibodies  Cysteine And Methionine Metabolism Pathway Diagram
 Folate Metabolism Pathway antibodies  Folate Metabolism Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Amino Acids And Derivatives Pathway antibodies  Metabolism Of Amino Acids And Derivatives Pathway Diagram
 Methionine Degradation Pathway antibodies  Methionine Degradation Pathway Diagram
 Methionine Degradation Pathway antibodies  Methionine Degradation Pathway Diagram
 Methylation Pathway antibodies  Methylation Pathway Diagram

Diseases associated with anti-AHCY antibody

 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >29 publications with AHCY and Disease Models, Animal
 Nervous System Diseases Antibodies  >24 publications with AHCY and Nervous System Diseases
 Brain Diseases Antibodies  >23 publications with AHCY and Brain Diseases
 Cardiovascular Diseases Antibodies  >22 publications with AHCY and Cardiovascular Diseases
 Liver Diseases Antibodies  >22 publications with AHCY and Liver Diseases
 Neoplasms, Experimental Antibodies  >19 publications with AHCY and Neoplasms, Experimental
 Amino Acid Metabolism, Inborn Errors Antibodies  >13 publications with AHCY and Amino Acid Metabolism, Inborn Errors
 Necrosis Antibodies  >12 publications with AHCY and Necrosis
 Liver Neoplasms Antibodies  >10 publications with AHCY and Liver Neoplasms
 Hepatitis Antibodies  >10 publications with AHCY and Hepatitis

Organs/Tissues associated with anti-AHCY antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >159 publications with AHCY and Liver
 Blood Antibodies  >143 publications with AHCY and Blood
 Brain Antibodies  >41 publications with AHCY and Brain
 Kidney Antibodies  >29 publications with AHCY and Kidney
 Placenta Antibodies  >25 publications with AHCY and Placenta
 Muscle Antibodies  >23 publications with AHCY and Muscle
 Heart Antibodies  >18 publications with AHCY and Heart
 Spleen Antibodies  >15 publications with AHCY and Spleen
 Vascular Antibodies  >14 publications with AHCY and Vascular
 Lung Antibodies  >11 publications with AHCY and Lung
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