Diamine Oxidase (DAO) ELISA Kit for Human

This gene encodes a metal-binding membrane glycoprotein that oxidatively deaminates putrescine, histamine, and related compounds. The encoded protein is inhibited by amiloride, a diuretic that acts by closing epithelial sodium ion channels. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2013]

ABP1: Catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis. Placental DAO is thought to play a role in the regulation of the female reproductive function. Belongs to the copper/topaquinone oxidase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Oxidoreductase; Amino Acid Metabolism - histidine; EC 1.4.3.22; Amino Acid Metabolism - arginine and proline; Secreted, signal peptide; Secreted; Amino Acid Metabolism - tryptophan

Chromosomal Location of Human Ortholog: 7q36.1

Cellular Component: extracellular space; tight junction; plasma membrane; peroxisome

Molecular Function: heparin binding; amine oxidase activity; copper ion binding; protein homodimerization activity; zinc ion binding; protein complex binding; drug binding; cation channel activity; receptor activity; calcium ion binding; sodium channel activity; quinone binding

Biological Process: response to drug; response to antibiotic; amine metabolic process