Tenascin R (TNR) ELISA Kit for Chicken

Name: Chicken TNR ELISA Kit; Tenascin R; MyBioSource
Brand: MyBioSource
SKU: MBS734227
Price: 580 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS734227

Principle of the assay: TNR ELISA kit applies the competitive enzyme immunoassay technique utilizing a monoclonal anti-TNR antibody and an TNR-HRP conjugate. The assay sample and buffer are incubated together with TNR-HRP conjugate in pre-coated plate for one… More details

$580 / 48-Strip-Wells +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

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Product Overview

Online Datasheet in PDF

Product Name

Tenascin R (TNR), ELISA Kit

Full Product Name

Chicken Tenascin R ELISA Kit

Product Gene Name

TNR elisa kit

Species Reactivity

Chicken

Assay Type

Competitive

Samples

Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate

Sensitivity

0.1 ng/mL.

Preparation and Storage

Store all reagents at 2-8 degree C

Molecular Weight

149,562 Da

Chromosome Location

Chromosome: 1; NC_000001.10 (175291935..175712752, complement). Location: 1q24

OMIM

601995

3D Structure

ModBase 3D Structure for Q92752

Sample Preparation

We suggest pre-experimenting with neat (undiluted) samples, 1:2 or 1:4 dilutions. Please avoid diluting your samples more than 1:10 as it would exceed the dilution limit set for this kit. If the expected concentration of the target is beyond the detection range of the kit, please contact our technical support team

Intended Uses

This TNR ELISA kit is a 1.5 hour solid-phase ELISA designed for the quantitative determination of Chicken TNR. This ELISA kit for research use only, not for therapeutic applications!

ISO Certification

Manufactured in an ISO 13485:2016 Certified Laboratory.

Other Notes

Small volumes of TNR elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TNR purchase

MBS734227 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Tenascin R (TNR) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing TNR. The ELISA analytical biochemical technique of the MBS734227 kit is based on TNR antibody-TNR antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect TNR antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, TNR. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Additional Details

NCBI/Uniprot data below describe general gene information for TNR. It may not necessarily be applicable to this product.

NCBI GI #

157384973

NCBI GeneID

7143

NCBI Accession #

NP_003276.3

UniProt Primary Accession #

Q92752

UniProt Secondary Accession #

Q15568; Q5R3G0; C9J563

UniProt Related Accession #

Q92752

GenBank Nucleotide #

NM_003285.2

NCBI Official Full Name

tenascin-R

NCBI Official Synonym Full Names

tenascin R (restrictin, janusin)

NCBI Official Symbol

TNR

NCBI Official Synonym Symbols

TN-R

UniProt Protein Name

Tenascin-R

UniProt Synonym Protein Names

Janusin; Restrictin

Protein Family

Tenascin

UniProt Gene Name

TNR

UniProt Synonym Gene Names

TN-R

UniProt Entry Name

TENR_HUMAN

NCBI Protein Information

tenascin-R; janusin; restrictin

NCBI Summary for TNR

Tenascin-R (TNR) is an extracellular matix protein expressed primarily in the central nervous system. It is a member of the tenascin (TN) gene family, which includes at least 3 genes in mammals: TNC (or hexabrachion; MIM 187380), TNX (TNXB; MIM 600985), and TNR (Erickson, 1993 [PubMed 7694605]). The genes are expressed in distinct tissues at different times during embryonic development and are present in adult tissues.[supplied by OMIM, Mar 2008]

UniProt Comments for TNR

TNR: Neural extracellular matrix (ECM) protein involved in interactions with different cells and matrix components. These interactions can influence cellular behavior by either evoking a stable adhesion and differentiation, or repulsion and inhibition of neurite growth. Binding to cell surface gangliosides inhibits RGD-dependent integrin-mediated cell adhesion and results in an inhibition of PTK2/FAK1 (FAK) phosphorylation and cell detachment. Binding to membrane surface sulfatides results in a oligodendrocyte adhesion and differentiation. Interaction with CNTN1 induces a repulsion of neurons and an inhibition of neurite outgrowth. Interacts with SCN2B may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier. TNR-linked chondroitin sulfate glycosaminoglycans are involved in the interaction with FN1 and mediate inhibition of cell adhesion and neurite outgrowth. The highly regulated addition of sulfated carbohydrate structure may modulate the adhesive properties of TNR over the course of development and during synapse maintenance. Belongs to the tenascin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 1q24

Cellular Component: nucleoplasm; proteinaceous extracellular matrix; cell surface; cytoplasm; extracellular region; nucleus; lipid raft

Biological Process: negative regulation of axon extension involved in regeneration; axon guidance; extracellular matrix organization and biogenesis; positive regulation of synaptic transmission, glutamatergic; negative regulation of synaptic transmission; synapse organization and biogenesis; neuron adhesion; negative regulation of cell-cell adhesion; neuromuscular process controlling balance; cell adhesion; associative learning; telencephalon cell migration; positive regulation of transmission of nerve impulse

Research Articles on TNR

1. results show that tenascin-R expression is tightly regulated in a spatiotemporal manner during brain development, especially cortical plate formation; its pattern of expression suggests a role for tenascin-R in corticogenesis

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with TNR elisa kit

Reference Product	PubMed Publications
BCAN elisa kit	>1 publications with TNR and BCAN

Pathways associated with TNR elisa kit

Products by Pathway	Pathway Diagram
ECM-receptor Interaction Pathway antibodies	ECM-receptor Interaction Pathway Diagram
ECM-receptor Interaction Pathway antibodies	ECM-receptor Interaction Pathway Diagram
Focal Adhesion Pathway antibodies	Focal Adhesion Pathway Diagram
Focal Adhesion Pathway antibodies	Focal Adhesion Pathway Diagram
Focal Adhesion Pathway antibodies	Focal Adhesion Pathway Diagram

Diseases associated with TNR elisa kit

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>32 publications with TNR and Nervous System Diseases
Neoplasms Antibodies	>24 publications with TNR and Neoplasms
Neurodegenerative Diseases Antibodies	>22 publications with TNR and Neurodegenerative Diseases
Mental Disorders Antibodies	>19 publications with TNR and Mental Disorders
Necrosis Antibodies	>10 publications with TNR and Necrosis
Genetic Predisposition to Disease Antibodies	>9 publications with TNR and Genetic Predisposition to Disease
Disease Models, Animal Antibodies	>7 publications with TNR and Disease Models, Animal
Movement Disorders Antibodies	>6 publications with TNR and Movement Disorders
Dementia Antibodies	>6 publications with TNR and Dementia
Cognition Disorders Antibodies	>6 publications with TNR and Cognition Disorders

Organs/Tissues associated with TNR elisa kit

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>27 publications with TNR and Brain
Liver Antibodies	>16 publications with TNR and Liver
Testis Antibodies	>2 publications with TNR and Testis
Placenta Antibodies	>1 publications with TNR and Placenta