Rabbit Anti-AAK1 Polyclonal Antibody – Cat# MBS840310

AAK1 Antibody – Rabbit Polyclonal

Name: AAK1 Antibody; Polyclonal; Rabbit; Human/Mouse/Rat-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS840310
Price: 215 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS840310

Background: AAK1 is a serine/threonine kinase that is thomught to coordinate the recruitment of AP-2 to receptors containing tyrosine-based internalization motifs by phosphorylating the u2 subunit. There is strong evidence that this protein is the endogenous… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

AAK1, Polyclonal Antibody

Full Product Name

AAK1 Antibody

Product Gene Name

anti-AAK1 antibody

Product Synonym Names

AAK-1; AAK1; AKK 1; AP2 associated kinase 1; Adaptor associated kinase 1

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Form/Format

100 ug (0.5 mg/ml) affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal.
Appearance: Colorless liquid

Purity/Purification

Affinity purified

Concentration

0.5 mg/ml (lot specific)

Preparation and Storage

At -20 degree C
Shelf Life: 12 months

Molecular Weight

74,515 Da

OMIM

300819

3D Structure

ModBase 3D Structure for Q2M218

Immunogen

Synthetic peptide surrounding amino acid 850 of human AAK1

Handling

The antibody solution should be gently mixed before use.

Applications Tested/Suitable for anti-AAK1 antibody

Western Blot (WB)

Application Notes for anti-AAK1 antibody

Western blotting (0.5-4 ug/ml). However, the optimal concentrations should be determined individually. The antibody recognizes ~95 kDa AAK1 in samples from human, mouse and rat origins. Reactivity to other species has not been tested.

Other Notes

Small volumes of anti-AAK1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for AAK1 purchase

MBS840310 is an antibody targeting AAK1. Also known as AAK1 Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for AAK1. It may not necessarily be applicable to this product.

NCBI GI #

170016085

NCBI GeneID

57232

NCBI Accession #

NP_001032824.2

UniProt Primary Accession #

Q2M218

UniProt Secondary Accession #

Q5H8Z5; F8WAG4

UniProt Related Accession #

Q2M218

GenBank Nucleotide #

NM_001037735.3

NCBI Official Full Name

zinc finger protein 630 isoform 1

NCBI Official Synonym Full Names

zinc finger protein 630

NCBI Official Symbol

ZNF630

NCBI Official Synonym Symbols

dJ54B20.2

UniProt Protein Name

Zinc finger protein 630

Protein Family

AP2-associated protein kinase

UniProt Gene Name

ZNF630

UniProt Entry Name

ZN630_HUMAN

NCBI Protein Information

zinc finger protein 630

NCBI Summary for AAK1

This gene encodes a protein containing an N-terminal Kruppel-associated box-containing (KRAB) domain and 13 Kruppel-type C2H2 zinc finger domains. This gene resides on an area of chromosome X that has been implicated in nonsyndromic X-linked mental retardation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

UniProt Comments for AAK1

ZNF630: May be involved in transcriptional regulation. Belongs to the krueppel C2H2-type zinc-finger protein family.

Protein type: C2H2-type zinc finger protein

Chromosomal Location of Human Ortholog: Xp11.3-p11.1

Cellular Component: nucleus

Molecular Function: DNA binding; metal ion binding; transcription factor activity

Biological Process: transcription, DNA-dependent; regulation of transcription, DNA-dependent

Research Articles on AAK1

1. Detected 12 ZNF630 deletions in a total of 1,562 male patients with mental retardation from Brazil, USA, Australia, and Europe. The breakpoints were analyzed in 10 families, and in all cases they were located within two segmental duplications.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-AAK1 antibody

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>1 publications with AAK1 and Nervous System Diseases

Organs/Tissues associated with anti-AAK1 antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>1 publications with AAK1 and Brain