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Aldo-Keto Reductase Family 1 Member C4 (AKR1C1) Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS206226

AKR1C1 also known as Aldo-keto reductase family 1 member C4, belongs to aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. It catalyzes the conversion of aldehydes and ketones to their corresponding alcohols by… More details

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Product Overview

Online Datasheet in PDF
Product Name
Aldo-keto reductase family 1 member C4 (AKR1C1), Active Protein
Full Product Name
Aldo-keto reductase family 1 member C4, 1-323aa, Human, E Coli (Bioactivity Validated)
Product Gene Name
AKR1C1 active protein
Product Synonym Names
3-alpha-HSD; C11; CDR; CHDR; DD-4; DD4; HAKRA
Sequence
MDPKYQRVEL NDGHFMPVLG FGTYAPPEVP RNRAVEVTKL AIEAGFRHID SAYLYNNEEQ VGLAIRSKIA DGSVKREDIF YTSKLWCTFF QPQMVQPALE SSLKKLQLDY VDLYLLHFPM ALKPGETPLP KDENGKVIFD TVDLSATWEV MEKCKDAGLA KSIGVSNFNC RQLEMILNKP GLKYKPVCNQ VECHPYLNQS KLLDFCKSKD IVLVAHSALG TQRHKLWVDP NSPVLLEDPV LCALAKKHKR TPALIALRYQ LQRGVVVLAK SYNEQRIREN IQVFEFQLTS EDMKVLDGLN RNYRYVVMDF LMDHPDYPFS DEY
Host
E Coli
Form/Format
Liquid. In 20mM Tris-HCl Buffer (pH 8.5) containing 0.1M NaCl, 10% glycerol, 1mM DTT
Purity/Purification
> 90% by SDS-PAGE
Concentration
1 mg/ml (determined by Bradford assay) (lot specific)
Preparation and Storage
Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
Molecular Weight
37kDa (323aa)
OMIM
S68287 mRNA
3D Structure
ModBase 3D Structure for P17516
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Antigen Species
Human
Endotoxin Level
< 1.0 EU per 1ug of protein (determined by LAL method)
Biological Activity
Specific activity is > 700 pmol/min/ug, and is defined as the amount of enzyme that catalyze the oxidation of 1.0 pmole 1-Acenaphthenol in the presence of NADP per minute at pH 8.8 at 25C.

Product Categories/Family for AKR1C1 active protein

Metabolism
Applications Tested/Suitable for AKR1C1 active protein
SDS-PAGE

SDS-Page of AKR1C1 active protein

AKR1C1 Active Protein – Cat# MBS206226

Product References and Citations for AKR1C1 active protein

Khanna M. et al. (1995) Genomics. 25 (2):588-90.; Stayrook KR. et al. (2008) Mol Pharmacol. 73 (2):607-12.

Other Notes

Small volumes of AKR1C1 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for AKR1C1 purchase

MBS206226 is an active protein targeting AKR1C1. Also known as Aldo-keto reductase family 1 member C4, 1-323aa, Human, E Coli (Bioactivity Validated). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for AKR1C1. It may not necessarily be applicable to this product.

NCBI GI #
325652083
NCBI GeneID
1109
NCBI Accession #
NP_001809
UniProt Primary Accession #
P17516
UniProt Secondary Accession #
Q5T6A3; Q8WW84; Q9NS54
UniProt Related Accession #
P17516
GenBank Nucleotide #
NM_001818.3
NCBI Official Full Name
aldo-keto reductase family 1 member C4
NCBI Official Synonym Full Names
aldo-keto reductase family 1 member C4
NCBI Official Symbol
AKR1C4
NCBI Official Synonym Symbols
C11; CDR; DD4; CHDR; DD-4; HAKRA; 3-alpha-HSD
UniProt Protein Name
Aldo-keto reductase family 1 member C4
UniProt Synonym Protein Names
3-alpha-HSD1; 3-alpha-hydroxysteroid dehydrogenase type I (EC:1.1.1.357); Chlordecone reductase (EC:1.1.1.225); CDR; Dihydrodiol dehydrogenase 4; DD-4; DD4; HAKRA
Protein Family
Aldo-keto reductase family
UniProt Gene Name
AKR1C4
UniProt Synonym Gene Names
CHDR; CDR; DD-4; DD4
NCBI Protein Information
aldo-keto reductase family 1 member C4

NCBI Summary for AKR1C1

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the bioreduction of chlordecone, a toxic organochlorine pesticide, to chlordecone alcohol in liver. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. [provided by RefSeq, Jul 2008]
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UniProt Comments for AKR1C1

Catalyzes the transformation of the potent androgen dihydrotestosterone (DHT) into the less active form, 5-alpha-androstan-3-alpha,17-beta-diol (3-alpha-diol). Also has some 20-alpha-hydroxysteroid dehydrogenase activity. The biotransformation of the pesticide chlordecone (kepone) to its corresponding alcohol leads to increased biliary excretion of the pesticide and concomitant reduction of its neurotoxicity since bile is the major excretory route.
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Research Articles on AKR1C1

1. the present study suggests that AKR1C1, AKR1C2, AKR1C3, and AKR1C4 are closely associated with drug resistance to both CDDP and 5FU, and that mefenamic acid, an inhibitor of AKR1C, restores sensitivity through inhibition of drug-resistance in human cancer cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with AKR1C1 active protein

 Reference Product  PubMed Publications
 AKR1D1 active protein  >6 publications with AKR1C1 and AKR1D1
 HSD11B1 active protein  >5 publications with AKR1C1 and HSD11B1
 SRD5A1 active protein  >5 publications with AKR1C1 and SRD5A1
 UGT1A1 active protein  >2 publications with AKR1C1 and UGT1A1
 UGT2B15 active protein  >1 publications with AKR1C1 and UGT2B15
 UGT2B4 active protein  >1 publications with AKR1C1 and UGT2B4

Pathways associated with AKR1C1 active protein

 Products by Pathway  Pathway Diagram
 Benzo(a)pyrene Metabolism Pathway antibodies  Benzo(a)pyrene Metabolism Pathway Diagram
 Bile Acid And Bile Salt Metabolism Pathway antibodies  Bile Acid And Bile Salt Metabolism Pathway Diagram
 Bile Acid Biosynthesis, Cholesterol => Cholate/chenodeoxycholate Pathway antibodies  Bile Acid Biosynthesis, Cholesterol => Cholate/chenodeoxycholate Pathway Diagram
 Bile Acid Biosynthesis, Cholesterol => Cholate/chenodeoxycholate Pathway antibodies  Bile Acid Biosynthesis, Cholesterol => Cholate/chenodeoxycholate Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Fat-soluble Vitamins Pathway antibodies  Metabolism Of Fat-soluble Vitamins Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Metabolism Of Vitamins And Cofactors Pathway antibodies  Metabolism Of Vitamins And Cofactors Pathway Diagram
 Metapathway Biotransformation antibodies  Metapathway Biotransformation Diagram

Diseases associated with AKR1C1 active protein

 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >6 publications with AKR1C1 and Breast Neoplasms
 Lung Neoplasms Antibodies  >5 publications with AKR1C1 and Lung Neoplasms
 Liver Neoplasms Antibodies  >5 publications with AKR1C1 and Liver Neoplasms
 Adenocarcinoma Antibodies  >5 publications with AKR1C1 and Adenocarcinoma
 Carcinoma, Hepatocellular Antibodies  >3 publications with AKR1C1 and Carcinoma, Hepatocellular
 Mental Disorders Antibodies  >2 publications with AKR1C1 and Mental Disorders
 Hyperplasia Antibodies  >2 publications with AKR1C1 and Hyperplasia
 Bipolar Disorder Antibodies  >2 publications with AKR1C1 and Bipolar Disorder
 Kidney Neoplasms Antibodies  >1 publications with AKR1C1 and Kidney Neoplasms
 Inflammation Antibodies  >1 publications with AKR1C1 and Inflammation

Organs/Tissues associated with AKR1C1 active protein

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >34 publications with AKR1C1 and Liver
 Testis Antibodies  >7 publications with AKR1C1 and Testis
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