Human Cellexp DLL-1 Active Protein – Cat# MBS844668

Sdll-1 (DLL-1) Human Cellexp Active Protein

Name: DLL-1 Active Protein; Sdll-1; Human Cellexp; MyBioSource
Brand: MyBioSource
SKU: MBS844668
Price: 275 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS844668

Background: Human sDLL-1 comprises the extracellular signaling domain of DLL-1, a member of a structurally-related family of single-pass type I trans-membrane proteins that serve as ligands for Notch receptors. It is expressed in the heart and pancreas, and… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

sDLL-1, Active Protein

Full Product Name

Human CellExp sDLL-1, Human Recombinant

Product Gene Name

DLL-1 active protein

Product Synonym Names

Delta-like protein 1; Delta-1

Sequence

SGVFELKLQE FVNKKGLLGN RNCCRGGAGP PPCACRTFFR VCLKHYQASV SPEPPCTYGS AVTPVLGVDS FSLPDGGGAD SAFSNPIRFP FGFTWPGTFS LIIEALHTDS PDDLATENPE RLISRLATQR HLTVGEEWSQ DLHSSGRTDL KYSYRFVCDE HYYGEGCSVF CRPRDDAFGH FTCGERGEKV CNPGWKGPYC TEPICLPGCD EQHGFCDKPG ECKCRVGWQG RYCDECIRYP GCLHGTCQQP WQCNCQEGWG GLFCNQDLNY CTHHKPCKNG ATCTNTGQGS YTCSCRPGYT GATCELGIDE CDPSPCKNGG SCTDLENSYS CTCPPGFYGK ICELSAMTCA DGPCFNGGRC SDSPDGGYSC RCPVGYSGFN CEKKIDYCSS SPCSNGAKCV DLGDAYLCRC QAGFSGRHCD DNVDDCASSP CANGGTCRDG VNDFSCTCPP GYTGRNCSAP VSRCEHAPCH NGATCHERGH RYVCECARGY GGPNCQFLLP ELPPGPAVVD LTEKLEGQGG PF

Host

HEK 293 cells

Form/Format

Sterile filtered through a 0.2 micron filter. Lyophilized from 1X PBS, pH 7.5.
Appearance: Lyophilized powder

Purity/Purification

>=95%

Preparation and Storage

At -20 degree C
Shelf Life: 12 months

Molecular Weight

57-60 kDa

OMIM

606582

3D Structure

ModBase 3D Structure for O00548

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Solubility/Reconstitution Instructions

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8 degree C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20 degree C to -80 degree C.

Endotoxin Level

< 0.1 ng/mug of protein (<1EU/mug).

Activity (Specifications/test method)

Determined by the dose dependent growth suppression of the human acute monocytic leukemia cell line, THP-1. sDLL-1 inhibits the proliferation in THP-1 cells using a concentration of 3.0-5.0 mug/ml.

Biological Activity

Determined by the dose dependent growth suppression of the human acute monocytic leukemia cell line, THP-1. sDLL-1 inhibits the proliferation in THP-1 cells using a concentration of 3.0-5.0 mug/ml.

Handling

Centrifuge the vial prior to opening.

Product Categories/Family for DLL-1 active protein

Cytokines; Growth Factors & Hormones; Human cell expressed recombinant proteins Proteins and Enzymes; Human cell expressed recombinant proteins Cytokines; Growth Factors & Hormones; Cytokines & Growth Factors (A-Z) Proteins and Enzymes; Cytokines; Growth

Applications Tested/Suitable for DLL-1 active protein

SDS-PAGE; HPLC

Other Notes

Small volumes of DLL-1 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DLL-1 purchase

MBS844668 is an active protein targeting DLL-1. Also known as Human CellExp sDLL-1, Human Recombinant. Host: HEK 293 cells.

Additional Details

NCBI/Uniprot data below describe general gene information for DLL-1. It may not necessarily be applicable to this product.

NCBI GI #

110735443

NCBI GeneID

28514

NCBI Accession #

NP_005609.3

UniProt Primary Accession #

O00548

UniProt Secondary Accession #

Q9NU41; Q9UJV2; B2RAK7; B5M0B3

UniProt Related Accession #

O00548

GenBank Nucleotide #

NM_005618.3

NCBI Official Full Name

delta-like protein 1

NCBI Official Synonym Full Names

delta-like 1 (Drosophila)

NCBI Official Symbol

DLL1

NCBI Official Synonym Symbols

DL1; Delta; DELTA1

UniProt Protein Name

Delta-like protein 1

UniProt Synonym Protein Names

Drosophila Delta homolog 1; Delta1; H-Delta-1

UniProt Gene Name

DLL1

UniProt Synonym Gene Names

Delta1; H-Delta-1

UniProt Entry Name

DLL1_HUMAN

NCBI Protein Information

delta-like protein 1

NCBI Summary for DLL-1

DLL1 is a human homolog of the Notch Delta ligand and is a member of the delta/serrate/jagged family. It plays a role in mediating cell fate decisions during hematopoiesis. It may play a role in cell-to-cell communication. [provided by RefSeq, Jul 2008]

UniProt Comments for DLL-1

DLL1: Acts as a ligand for Notch receptors. Blocks the differentiation of progenitor cells into the B-cell lineage while promoting the emergence of a population of cells with the characteristics of a T-cell/NK-cell precursor. Interacts with Notch receptors. Expressed in heart and pancreas, with lower expression in brain and muscle and almost no expression in placenta, lung, liver and kidney.

Protein type: Cell development/differentiation; Motility/polarity/chemotaxis; Membrane protein, integral

Chromosomal Location of Human Ortholog: 6q27

Cellular Component: integral to plasma membrane; extracellular region; plasma membrane; cytoplasmic vesicle

Molecular Function: protein binding; calcium ion binding; Notch binding

Biological Process: regulation of cell adhesion; Notch signaling pathway; negative regulation of myeloid cell differentiation; negative regulation of interleukin-10 production; Notch receptor processing; cell fate determination; compartment specification; somite specification; cell-cell signaling; negative regulation of auditory receptor cell differentiation; hemopoiesis; positive regulation of transcription from RNA polymerase II promoter; heart looping; cell differentiation; determination of left/right symmetry; inner ear development; positive regulation of Notch signaling pathway

Research Articles on DLL-1

1. determined the X-ray crystal structure of the extracellular domain of the Notch ligand delta-like ligand-1 (Dll-1)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with DLL-1 active protein

Reference Product	PubMed Publications
NOTCH1 active protein	>115 publications with DLL-1 and NOTCH1
NOTCH3 active protein	>19 publications with DLL-1 and NOTCH3
NOTCH4 active protein	>15 publications with DLL-1 and NOTCH4
MIB1 active protein	>5 publications with DLL-1 and MIB1
PSEN1 active protein	>3 publications with DLL-1 and PSEN1
ADAM10 active protein	>3 publications with DLL-1 and ADAM10
ADAM12 active protein	>2 publications with DLL-1 and ADAM12

Diseases associated with DLL-1 active protein

Disease Name	Pubmed Publications
Congenital Abnormalities Antibodies	>12 publications with DLL-1 and Congenital Abnormalities
Inflammation Antibodies	>11 publications with DLL-1 and Inflammation
Immune System Diseases Antibodies	>11 publications with DLL-1 and Immune System Diseases
Disease Models, Animal Antibodies	>11 publications with DLL-1 and Disease Models, Animal
Carcinoma Antibodies	>10 publications with DLL-1 and Carcinoma
Nervous System Diseases Antibodies	>8 publications with DLL-1 and Nervous System Diseases
Abnormalities, Multiple Antibodies	>6 publications with DLL-1 and Abnormalities, Multiple
Necrosis Antibodies	>5 publications with DLL-1 and Necrosis
Lung Diseases Antibodies	>5 publications with DLL-1 and Lung Diseases
Skin Diseases Antibodies	>4 publications with DLL-1 and Skin Diseases

Organs/Tissues associated with DLL-1 active protein

Organ/Tissue Name	Pubmed Publications
Embryonic Tissue Antibodies	>41 publications with DLL-1 and Embryonic Tissue
Brain Antibodies	>39 publications with DLL-1 and Brain
Lung Antibodies	>16 publications with DLL-1 and Lung
Intestine Antibodies	>12 publications with DLL-1 and Intestine
Kidney Antibodies	>9 publications with DLL-1 and Kidney
Eye Antibodies	>7 publications with DLL-1 and Eye
Skin Antibodies	>6 publications with DLL-1 and Skin
Ear Antibodies	>5 publications with DLL-1 and Ear
Placenta Antibodies	>4 publications with DLL-1 and Placenta
Lymph Node Antibodies	>4 publications with DLL-1 and Lymph Node