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5T4 Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS2153302

MBS2153302 is an active protein targeting 5T4. Also known as Active 5T4. Host: 293F Cell. More details

$250 / 0.01 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
5T4, Active Protein
Full Product Name
Active 5T4
Product Gene Name
Product Synonym Names
5T4; 5T4 active protein (eukaryotic, 293F Cell), Human; 5T4-AG; M6P1; WAIF1; 5T4 oncofetal trophoblast glycoprotein; Wnt-activated inhibitory factor 1; Trophoblast Glycoprotein
Host
293F Cell
Form/Format
PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
Freeze-dried powder
Purity/Purification
Greater than 90% by SDS-PAGE
Preparation and Storage
Store at 2-8 degree C for one month, -80 degree C for 12 months
Stable for 12 months if correctly stored.
Molecular Weight
46,032 Da
Sequence Positions
Ser32~Ser355
Chromosome Location
Chromosome: 6; NC_000006.11 (83072923..83077134). Location: 6q14-q15
OMIM
190920
3D Structure
ModBase 3D Structure for Q13641
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Expression System
Eukaryotic expression
Species
Human
Tag
N-terminal His
Endotoxin Level
<1.0EU per 1ug (determined by the LAL method)
Isoelectric Point
5.8
Research Area
Tumor immunity

Product Categories/Family for 5T4 active protein

ISO Certification
Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
Applications Tested/Suitable for 5T4 active protein
Cell culture, Activity Assay

SDS-PAGE of 5T4 active protein

Figure. SDS-PAGE
5T4 Active Protein – Cat# MBS2153302

Other Notes

Small volumes of 5T4 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for 5T4. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
trophoblast glycoprotein
NCBI Official Synonym Full Names
trophoblast glycoprotein
NCBI Official Symbol
TPBG
NCBI Official Synonym Symbols
5T4; M6P1; 5T4AG
UniProt Protein Name
Trophoblast glycoprotein
UniProt Synonym Protein Names
5T4 oncofetal antigen; 5T4 oncofetal trophoblast glycoprotein; 5T4 oncotrophoblast glycoprotein; M6P1
UniProt Gene Name
TPBG
UniProt Synonym Gene Names
5T4; 5T4 oncotrophoblast glycoprotein
UniProt Entry Name
TPBG_HUMAN
NCBI Protein Information
trophoblast glycoprotein; 5T4 oncofetal antigen; 5T4 oncotrophoblast glycoprotein; 5T4 oncofetal trophoblast glycoprotein

NCBI Summary for 5T4

This gene encodes a leucine-rich transmembrane glycoprotein that may be involved in cell adhesion. The encoded protein is an oncofetal antigen that is specific to trophoblast cells. In adults this protein is highly expressed in many tumor cells and is associated with poor clinical outcome in numerous cancers. Alternate splicing in the 5' UTR results in multiple transcript variants that encode the same protein. [provided by RefSeq, Oct 2009]
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UniProt Comments for 5T4

Subcellular location: Membrane; Single-pass type I membrane protein

Potential.

Tissue specificity: Expressed by all types of trophoblasts as early as 9 weeks of development. Specific for trophoblastic cells except for amniotic epithelium. In adult tissues, the expression is limited to a few epithelial cell types but is found on a variety of carcinoma.

Miscellaneous: Antigen 5T4 is overexpressed by a wide spectrum of cancers, including colorectal, ovarian and gastric, but with a limited normal tissue expression. Could be used for tumor immunotherapy.

Sequence similarities: Contains 6 LRR (leucine-rich) repeats.Contains 1 LRRCT domain.Contains 1 LRRNT domain.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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