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CD31/PECAM1 (PECAM1) Human Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9139693

Description: Recombinant Human CD31/PECAM1 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gln28-Lys601) of human CD31/PECAM1 (Accession #NP_000433.4) fused with a 6xHis tag at the C-terminus.Background:… More details

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Product Overview

Online Datasheet in PDF
Product Name
CD31/PECAM1, Active Protein
Full Product Name
Recombinant Human CD31/PECAM1 Protein
Product Gene Name
PECAM1 active protein
Product Synonym Gene Name
CD31
Product Synonym Names
CD31; CD31/EndoCAM; endoCAM; GPIIA; PECA1; PECAM-1
Sequence
QENSFTINSV DMKSLPDWTV QNGKNLTLQC FADVSTTSHV KPQHQMLFYK DDVLFYNISS MKSTESYFIP EVRIYDSGTY KCTVIVNNKE KTTAEYQVLV EGVPSPRVTL DKKEAIQGGI VRVNCSVPEE KAPIHFTIEK LELNEKMVKL KREKNSRDQN FVILEFPVEE QDRVLSFRCQ ARIISGIHMQ TSESTKSELV TVTESFSTPK FHISPTGMIM EGAQLHIKCT IQVTHLAQEF PEIIIQKDKA IVAHNRHGNK AVYSVMAMVE HSGNYTCKVE SSRISKVSSI VVNITELFSK PELESSFTHL DQGERLNLSC SIPGAPPANF TIQKEDTIVS QTQDFTKIAS KSDSGTYICT AGIDKVVKKS NTVQIVVCEM LSQPRISYDA QFEVIKGQTI EVRCESISGT LPISYQLLKT SKVLENSTKN SNDPAVFKDN PTEDVEYQCV ADNCHSHAKM LSEVLRVKVI APVDEVQISI LSSKVVESGE DIVLQCAVNE GSGPITYKFY REKEGKPFYQ MTSNATQAFW TKQKASKEQE GEYYCTAFNR ANHASSVPRS KILTVRVILA PWKK
Host
HEK293 Cells
Form/Format
Lyophilized from a 0.22 um filtered solution of PBS, pH 7.4.
Purity/Purification
>90% by SDS-PAGE.
Preparation and Storage
Store the lyophilized protein at -20 degree C to -80 degree C for long term.
After reconstitution, the protein solution is stable at -20 degree C for 3 months, at 2-8 degree C for up to 1 week.
OMIM
173445
3D Structure
ModBase 3D Structure for P16284
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Species
Human
Endotoxin
< 0.1 EU/ug of the protein by LAL method.
Biological Activity
Measured by its ability of the immobilized protein to support the adhesion of Jurkat human acute T cell leukemia cells. When 5 x 104 cells/well are added to rhCD31 coated plates (3.3 ug/mL, 100 uL/well) in the presence of 20 ng/mL PMA, approximately 50-65% will adhere after 30 minutes at 37 degree C.
Reconstitution
Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water.
Tag
6xHis tag at the C-terminus

Product Categories/Family for PECAM1 active protein

CD Antigen
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

SDS-Page of PECAM1 active protein

Recombinant Human CD31/PECAM1 Protein was determined by SDS-PAGE with Coomassie Blue, showing a band at 85-105 kDa.
Human PECAM1 Active Protein – Cat# MBS9139693

Other Notes

Small volumes of PECAM1 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PECAM1 purchase

MBS9139693 is an active protein targeting PECAM1. Also known as Recombinant Human CD31/PECAM1 Protein. Host: HEK293 Cells.

Additional Details

NCBI/Uniprot data below describe general gene information for PECAM1. It may not necessarily be applicable to this product.

NCBI GI #
313760624
NCBI GeneID
5175
NCBI Accession #
NP_000433.4
UniProt Primary Accession #
P16284
UniProt Related Accession #
P16284
GenBank Nucleotide #
NP_000433.4
NCBI Official Full Name
platelet endothelial cell adhesion molecule
NCBI Official Synonym Full Names
platelet and endothelial cell adhesion molecule 1
NCBI Official Symbol
PECAM1
NCBI Official Synonym Symbols
CD31; PECA1; GPIIA'; PECAM-1; endoCAM; CD31/EndoCAM
UniProt Protein Name
Platelet endothelial cell adhesion molecule
UniProt Synonym Protein Names
EndoCAM; GPIIA'; PECA1
Protein Family
Platelet endothelial cell adhesion molecule
UniProt Gene Name
PECAM1
UniProt Synonym Gene Names
PECAM-1
UniProt Entry Name
PECA1_HUMAN
NCBI Protein Information
platelet endothelial cell adhesion molecule

NCBI Summary for PECAM1

The protein encoded by this gene is found on the surface of platelets, monocytes, neutrophils, and some types of T-cells, and makes up a large portion of endothelial cell intercellular junctions. The encoded protein is a member of the immunoglobulin superfamily and is likely involved in leukocyte migration, angiogenesis, and integrin activation. [provided by RefSeq, May 2010]
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UniProt Comments for PECAM1

PECAM-1: a cell adhesion molecule expressed on platelets and at endothelial cell intercellular junctions. Plays a role in modulation of integrin-mediated cell adhesion, transendothelial migration, angiogenesis, apoptosis, cell migration, negative regulation of immune cell signaling, autoimmunity, macrophage phagocytosis, IgE-mediated anaphylaxis and thrombosis. Undergoes alternative splicing, generating multiple isoforms in vascular beds of various tissues.

Protein type: Cell adhesion; Membrane protein, integral

Chromosomal Location of Human Ortholog: 17q23.3

Cellular Component: extracellular space; platelet alpha granule membrane; integral to membrane; plasma membrane; cell junction

Molecular Function: protein binding

Biological Process: platelet activation; extracellular matrix organization and biogenesis; platelet degranulation; diapedesis; cell recognition; blood coagulation; signal transduction; cell adhesion; leukocyte migration; phagocytosis
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Research Articles on PECAM1

1. Multivariate analysis showed VEGF and MVD were not independent prognostic factors for OS. High-grade serous ovarian cancer (HGSOC) intratumoural vasculature did not undergo significant changes during disease progression. High concentration of CD31((+)) vessels seems to promote recruitment of effector TILs.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with PECAM1 active protein

 Reference Product  PubMed Publications
 CD38 active protein  >63 publications with PECAM1 and CD38
 SRC active protein  >58 publications with PECAM1 and SRC
 CTNNB1 active protein  >42 publications with PECAM1 and CTNNB1
 PTPN11 active protein  >33 publications with PECAM1 and PTPN11
 PTPN6 active protein  >17 publications with PECAM1 and PTPN6
 CSK active protein  >6 publications with PECAM1 and CSK
 FYN active protein  >5 publications with PECAM1 and FYN
 ITGB3 active protein  >4 publications with PECAM1 and ITGB3
 LYN active protein  >3 publications with PECAM1 and LYN
 JUP active protein  >3 publications with PECAM1 and JUP

Pathways associated with PECAM1 active protein

 Products by Pathway  Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Integrin Cell Surface Interactions Pathway antibodies  Integrin Cell Surface Interactions Pathway Diagram
 Leukocyte Transendothelial Migration Pathway antibodies  Leukocyte Transendothelial Migration Pathway Diagram
 Leukocyte Transendothelial Migration Pathway antibodies  Leukocyte Transendothelial Migration Pathway Diagram
 Malaria Pathway antibodies  Malaria Pathway Diagram
 Malaria Pathway antibodies  Malaria Pathway Diagram
 PECAM1 Interactions Pathway antibodies  PECAM1 Interactions Pathway Diagram

Diseases associated with PECAM1 active protein

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >1570 publications with PECAM1 and Neoplasms
 Inflammation Antibodies  >443 publications with PECAM1 and Inflammation
 Necrosis Antibodies  >373 publications with PECAM1 and Necrosis
 Neoplasms, Experimental Antibodies  >235 publications with PECAM1 and Neoplasms, Experimental
 Neoplasm Metastasis Antibodies  >228 publications with PECAM1 and Neoplasm Metastasis
 Lung Diseases Antibodies  >211 publications with PECAM1 and Lung Diseases
 Heart Diseases Antibodies  >210 publications with PECAM1 and Heart Diseases
 Breast Neoplasms Antibodies  >187 publications with PECAM1 and Breast Neoplasms
 Lung Neoplasms Antibodies  >164 publications with PECAM1 and Lung Neoplasms
 Liver Diseases Antibodies  >149 publications with PECAM1 and Liver Diseases

Organs/Tissues associated with PECAM1 active protein

 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >3069 publications with PECAM1 and Vascular
 Blood Antibodies  >2726 publications with PECAM1 and Blood
 Muscle Antibodies  >607 publications with PECAM1 and Muscle
 Bone Marrow Antibodies  >397 publications with PECAM1 and Bone Marrow
 Lung Antibodies  >384 publications with PECAM1 and Lung
 Heart Antibodies  >313 publications with PECAM1 and Heart
 Brain Antibodies  >289 publications with PECAM1 and Brain
 Liver Antibodies  >270 publications with PECAM1 and Liver
 Umbilical Cord Antibodies  >216 publications with PECAM1 and Umbilical Cord
 Kidney Antibodies  >215 publications with PECAM1 and Kidney
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