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FGF17 Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS553633

MBS553633 is an active protein targeting FGF17. Host: E Coli (Host protein expression may be lot-specific and can be subject to change during production, including bulk orders). More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
FGF17, Active Protein
Full Product Name
FGF17
Product Gene Name
FGF17 active protein
Sequence
MTQGENHPSP NFNQYVRDQG AMTDQLSRRQ IREYQLYSRT SGKHVQVTGR RISATAEDGN KFAKLIVETD TFGSRVRIKG AESEKYICMN KRGKLIGKPS GKSKDCVFTE IVLENNYTAF QNARHEGWFM AFTRQGRPRQ ASRSRQNQRE AHFIKRLYQG QLPFPNHAEK QKQFEFVGSA PTRRTKRTRR PQPLT
Host
E Coli (Host protein expression may be lot-specific and can be subject to change during production, including bulk orders)
Form/Format
Lyophilized; PBS, pH 7.2
Purity/Purification
>95%, as determined by SDS-PAGE and HPLC.
Preparation and Storage
The lyophilized protein is stable for at least 2 years from date of receipt at -20 degree C. Upon reconstitution, this product can be stored in working aliquots at 2 degree C - 8 degree C for one month, or at -20 degree C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.
Molecular Weight
23,669 Da
3D Structure
ModBase 3D Structure for O60258
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Species
Human
Source Note
Optimized DNA sequence encoding Human FGF17 mature chain was expressed in ECOLI. Recombinant Human Fibroblast growth factor 17 encodes amino acid residues 23-216.
Biological Activity
The ED50 as determined by the dose-dependent stimulation of thymidine uptake by BaF3 cells expressing FGF-receptors is = 0.5 ng/ml
Endotoxin
Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/ug(1EU/ug).
Reconstitution
A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.
Applications Tested/Suitable for FGF17 active protein
SDS-PAGE
Application Notes for FGF17 active protein
Recombinant FGF17 migrates as an approximately 21 kDa protein under reducing conditions in SDS-PAGE.

Other Notes

Small volumes of FGF17 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for FGF17. It may not necessarily be applicable to this product.

NCBI GI #
4503693
NCBI GeneID
8822
NCBI Accession #
NP_003858.1
UniProt Primary Accession #
O60258
UniProt Secondary Accession #
Q2M2W1; B7ZLG4
UniProt Related Accession #
O60258
GenBank Nucleotide #
NM_003867.4
NCBI Official Full Name
fibroblast growth factor 17 isoform 1
NCBI Official Synonym Full Names
fibroblast growth factor 17
NCBI Official Symbol
FGF17
NCBI Official Synonym Symbols
HH20; FGF-13; FGF-17
UniProt Protein Name
Fibroblast growth factor 17
Protein Family
Fibroblast growth factor
UniProt Gene Name
FGF17
UniProt Synonym Gene Names
FGF-17
NCBI Protein Information
fibroblast growth factor 17

NCBI Summary for FGF17

This gene encodes a member of the fibroblast growth factor (FGF) family. Member of the FGF family possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is expressed during embryogenesis and in the adult cerebellum and cortex and may be essential for vascular growth and normal brain development. Mutations in this gene are the cause of hypogonadotropic hypogonadism 20 with or without anosmia. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
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UniProt Comments for FGF17

Plays an important role in the regulation of embryonic development and as signaling molecule in the induction and patterning of the embryonic brain. Required for normal brain development.

Research Articles on FGF17

1. FGF17 and IL17RD prpopsed as the two top candidates in the entire proteome on the basis of a statistical test of their protein-protein interaction patterns to proteins known to be altered in congenital hypogonadotropic hypogonadism.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with FGF17 active protein

 Reference Product  PubMed Publications
 FGFR1 active protein  >10 publications with FGF17 and FGFR1
 SHH active protein  >6 publications with FGF17 and SHH
 FGFR2 active protein  >6 publications with FGF17 and FGFR2
 FGFR3 active protein  >5 publications with FGF17 and FGFR3
 FGFR4 active protein  >3 publications with FGF17 and FGFR4
 MET active protein  >2 publications with FGF17 and MET

Pathways associated with FGF17 active protein

 Products by Pathway  Pathway Diagram
 Activated Point Mutants Of FGFR2 Pathway antibodies  Activated Point Mutants Of FGFR2 Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Constitutive PI3K/AKT Signaling In Cancer Pathway antibodies  Constitutive PI3K/AKT Signaling In Cancer Pathway Diagram
 DAP12 Interactions Pathway antibodies  DAP12 Interactions Pathway Diagram
 DAP12 Signaling Pathway antibodies  DAP12 Signaling Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Downstream Signal Transduction Pathway antibodies  Downstream Signal Transduction Pathway Diagram
 Downstream Signaling Events Of B Cell Receptor (BCR) Pathway antibodies  Downstream Signaling Events Of B Cell Receptor (BCR) Pathway Diagram
 Downstream Signaling Of Activated FGFR Pathway antibodies  Downstream Signaling Of Activated FGFR Pathway Diagram
 FGFR Ligand Binding And Activation Pathway antibodies  FGFR Ligand Binding And Activation Pathway Diagram

Diseases associated with FGF17 active protein

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >5 publications with FGF17 and Nervous System Diseases
 Brain Diseases Antibodies  >4 publications with FGF17 and Brain Diseases
 Hyperplasia Antibodies  >2 publications with FGF17 and Hyperplasia
 Learning Disorders Antibodies  >2 publications with FGF17 and Learning Disorders
 Skin Abnormalities Antibodies  >1 publications with FGF17 and Skin Abnormalities
 Breast Neoplasms Antibodies  >1 publications with FGF17 and Breast Neoplasms
 Movement Disorders Antibodies  >1 publications with FGF17 and Movement Disorders
 Seizures Antibodies  >1 publications with FGF17 and Seizures
 Abnormalities, Multiple Antibodies  >1 publications with FGF17 and Abnormalities, Multiple
 Skin Diseases Antibodies  >1 publications with FGF17 and Skin Diseases

Organs/Tissues associated with FGF17 active protein

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >31 publications with FGF17 and Brain
 Embryonic Tissue Antibodies  >15 publications with FGF17 and Embryonic Tissue
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