Human GM-CSF/CSF2 Active Protein – Cat# MBS2557271

GM-CSF/CSF2 Human Active Protein

Name: GM-CSF/CSF2 Active Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS2557271
Price: 265 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS2557271

Protein Construction: Recombinant Human Granulocyte-Macrophage Colony-Stimulating Factor is produced by our E Coli expression system and the target gene encoding Ala18-Glu144 is expressed.Background: Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF)… More details

$265 / 0.02 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

GM-CSF/CSF2, Active Protein

Full Product Name

Recombinant Human GM-CSF/CSF2 Protein

Product Gene Name

GM-CSF/CSF2 active protein

Product Synonym Names

Granulocyte-Macrophage Colony-Stimulating Factor; GM-CSF; Colony-Stimulating Factor; CSF; Molgramostin; Sargramostim; CSF2; GMCSF

Sequence

Ala18-Glu1 44

Host

E Coli

Form/Format

Lyophilized from a 0.2 mum filtered solution of PBS, pH7.4.

Purity/Purification

>95% as determined by reducing SDS-PAGE.

Preparation and Storage

Lyophilized protein should be stored at < -20 degree C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.

Molecular Weight

Molecular Mass: 14.6kDa
Actual Protein Molecular Mass: 14kDa

OMIM

138960

3D Structure

ModBase 3D Structure for P04141

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Species

Human

Endotoxin

< 1.0 EU per mug as determined by the LAL method.

Activity

Measured in a cell proliferation assay using TF-1 human erythroleukemic cells. The ED50 for this effect is 4-20 pg/mL.

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of GM-CSF/CSF2 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GM-CSF/CSF2 purchase

MBS2557271 is an active protein targeting GM-CSF/CSF2. Also known as Recombinant Human GM-CSF/CSF2 Protein. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for GM-CSF/CSF2. It may not necessarily be applicable to this product.

NCBI GI #

183364

NCBI GeneID

1437

NCBI Accession #

AAA52578.1

UniProt Primary Accession #

P04141

UniProt Related Accession #

P04141

NCBI Official Full Name

GM-CSF

NCBI Official Synonym Full Names

colony stimulating factor 2

NCBI Official Symbol

CSF2

NCBI Official Synonym Symbols

CSF; GMCSF

UniProt Protein Name

Granulocyte-macrophage colony-stimulating factor

UniProt Synonym Protein Names

Colony-stimulating factor; CSF; Molgramostin; Sargramostim

UniProt Gene Name

CSF2

UniProt Synonym Gene Names

GMCSF; GM-CSF; CSF

UniProt Entry Name

CSF2_HUMAN

NCBI Protein Information

granulocyte-macrophage colony-stimulating factor

NCBI Summary for GM-CSF/CSF2

The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes and macrophages. The active form of the protein is found extracellularly as a homodimer. This gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include those encoding interleukins 4, 5, and 13. [provided by RefSeq, Jul 2008]

Research Articles on GM-CSF/CSF2

1. Study demonstrates that GM-CSF signaling is an important mechanism to tune macrophage inflammatory state and improve Mycobacterium tuberculosis (Mtb) control and that this pathway can be manipulated by pathogens to drive a more permissive bacterial state. Blocking GM-CSF makes macrophages more permissive of Mtb growth while addition of GM-CSF increases bacterial control.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with GM-CSF/CSF2 active protein

Reference Product	PubMed Publications
IL4 active protein	>14 publications with GM-CSF/CSF2 and IL4
IL3 active protein	>12 publications with GM-CSF/CSF2 and IL3
IL5 active protein	>8 publications with GM-CSF/CSF2 and IL5
CSF2RB active protein	>7 publications with GM-CSF/CSF2 and CSF2RB
CSF2RA active protein	>4 publications with GM-CSF/CSF2 and CSF2RA
FOS active protein	>2 publications with GM-CSF/CSF2 and FOS
STAT3 active protein	>1 publications with GM-CSF/CSF2 and STAT3
JAK2 active protein	>1 publications with GM-CSF/CSF2 and JAK2
SDC2 active protein	>1 publications with GM-CSF/CSF2 and SDC2

Pathways associated with GM-CSF/CSF2 active protein

Products by Pathway	Pathway Diagram
Amoebiasis Pathway antibodies	Amoebiasis Pathway Diagram
Amoebiasis Pathway antibodies	Amoebiasis Pathway Diagram
Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway antibodies	Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway Diagram
Calcium Signaling In The CD4+ TCR Pathway antibodies	Calcium Signaling In The CD4+ TCR Pathway Diagram
Cytokine Signaling In Immune System Pathway antibodies	Cytokine Signaling In Immune System Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokines And Inflammatory Response Pathway antibodies	Cytokines And Inflammatory Response Pathway Diagram
Fc Epsilon RI Signaling Pathway antibodies	Fc Epsilon RI Signaling Pathway Diagram
Fc Epsilon RI Signaling Pathway antibodies	Fc Epsilon RI Signaling Pathway Diagram

Diseases associated with GM-CSF/CSF2 active protein

Disease Name	Pubmed Publications
Inflammation Antibodies	>29 publications with GM-CSF/CSF2 and Inflammation
Necrosis Antibodies	>22 publications with GM-CSF/CSF2 and Necrosis
Neoplasms Antibodies	>19 publications with GM-CSF/CSF2 and Neoplasms
Lung Diseases Antibodies	>8 publications with GM-CSF/CSF2 and Lung Diseases
Breast Neoplasms Antibodies	>5 publications with GM-CSF/CSF2 and Breast Neoplasms
Carcinoma Antibodies	>3 publications with GM-CSF/CSF2 and Carcinoma
Drug Toxicity Antibodies	>3 publications with GM-CSF/CSF2 and Drug Toxicity
Leukemia, Myeloid, Acute Antibodies	>3 publications with GM-CSF/CSF2 and Leukemia, Myeloid, Acute
Liver Diseases Antibodies	>3 publications with GM-CSF/CSF2 and Liver Diseases
Lung Neoplasms Antibodies	>3 publications with GM-CSF/CSF2 and Lung Neoplasms

Organs/Tissues associated with GM-CSF/CSF2 active protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>33 publications with GM-CSF/CSF2 and Blood
Bone Antibodies	>10 publications with GM-CSF/CSF2 and Bone
Lung Antibodies	>8 publications with GM-CSF/CSF2 and Lung
Intestine Antibodies	>1 publications with GM-CSF/CSF2 and Intestine