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IL-16 Human Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9139641

Description: Recombinant Human IL-16 Protein is produced by E. coli expression system. The target protein is expressed with sequence (Pro2-Ser130) of human IL-16 (Accession #NP_757366.2) fused with a 6xHis tag at the C-terminus.Background: The protein is a… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
IL-16, Active Protein
Full Product Name
Recombinant Human IL-16 Protein
Product Gene Name
IL-16 active protein
Product Synonym Gene Name
IL16
Product Synonym Names
LCF; NIL16; prIL-16; PRIL16
Sequence
PDLNSSTDSA ASASAASDVS VESTAEATVC TVTLEKMSAG LGFSLEGGKG SLHGDKPLTI NRIFKGAASE QSETVQPGDE ILQLGGTAMQ GLTRFEAWNI IKALPDGPVT IVIRRKSLQS KETTAAGDS
Host
E Coli
Form/Format
Lyophilized from a 0.22 um filtered solution of 20mM Tris, 150mM NaCl, pH 8.0.
Purity/Purification
>97% by SDS-PAGE.
Preparation and Storage
Store the lyophilized protein at -20 degree C to -80 degree C for long term.
After reconstitution, the protein solution is stable at -20 degree C for 3 months, at 2-8 degree C for up to 1 week.
OMIM
603035
3D Structure
ModBase 3D Structure for Q14005
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Species
Human
Endotoxin
< 0.1 EU/ug of the protein by LAL method.
Biological Activity
Measured by its ability to bind recombinant human CD4-Fc in a functional ELISA.
Reconstitution
Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water.
Tag
6xHis tag at the C-terminus

Product Categories/Family for IL-16 active protein

Cytokines & Cytokine Receptors
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

SDS-Page of IL-16 active protein

Recombinant Human IL-16 Protein was determined by SDS-PAGE with Coomassie Blue, showing a band at approximately 20 kDa.
Human IL-16 Active Protein – Cat# MBS9139641

Other Notes

Small volumes of IL-16 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IL-16 purchase

MBS9139641 is an active protein targeting IL-16. Also known as Recombinant Human IL-16 Protein. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for IL-16. It may not necessarily be applicable to this product.

NCBI GI #
223460532
NCBI GeneID
3603
NCBI Accession #
AAI36661.1
UniProt Primary Accession #
Q14005
UniProt Related Accession #
Q14005
NCBI Official Full Name
IL16 protein
NCBI Official Synonym Full Names
interleukin 16
NCBI Official Symbol
IL16
NCBI Official Synonym Symbols
LCF; NIL16; PRIL16; prIL-16
UniProt Protein Name
Pro-interleukin-16
UniProt Synonym Protein Names
Lymphocyte chemoattractant factor
UniProt Gene Name
IL16
UniProt Synonym Gene Names
IL-16; LCF
UniProt Entry Name
IL16_HUMAN
NCBI Protein Information
pro-interleukin-16

NCBI Summary for IL-16

The protein encoded by this gene is a pleiotropic cytokine that functions as a chemoattractant, a modulator of T cell activation, and an inhibitor of HIV replication. The signaling process of this cytokine is mediated by CD4. The product of this gene undergoes proteolytic processing, which is found to yield two functional proteins. The cytokine function is exclusively attributed to the secreted C-terminal peptide, while the N-terminal product may play a role in cell cycle control. Caspase 3 is reported to be involved in the proteolytic processing of this protein. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]
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UniProt Comments for IL-16

IL16: Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4. 3 isoforms of the human protein are produced by alternative promoter.

Protein type: Cytokine; DNA-binding; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 15q26.3

Cellular Component: extracellular space; cytoplasm; plasma membrane; nucleus

Molecular Function: cytokine activity

Biological Process: viral reproduction; regulation of transcription, DNA-dependent; transcription, DNA-dependent; leukocyte chemotaxis; immune response; induction of positive chemotaxis
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Research Articles on IL-16

1. A moderate increase in total dietary fat resulted in a 2.7-fold reduction in eosinophil IL-16 content among C57BL/6-IL5tg mice.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with IL-16 active protein

 Reference Product  PubMed Publications
 CD4 active protein  >214 publications with IL-16 and CD4
 CASP3 active protein  >28 publications with IL-16 and CASP3
 CCR5 active protein  >15 publications with IL-16 and CCR5
 IL2RA active protein  >8 publications with IL-16 and IL2RA
 IL2 active protein  >5 publications with IL-16 and IL2
 FOS active protein  >2 publications with IL-16 and FOS
 MAP2K4 active protein  >1 publications with IL-16 and MAP2K4

Diseases associated with IL-16 active protein

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >92 publications with IL-16 and Inflammation
 Lung Diseases Antibodies  >56 publications with IL-16 and Lung Diseases
 Necrosis Antibodies  >47 publications with IL-16 and Necrosis
 Intestinal Diseases Antibodies  >21 publications with IL-16 and Intestinal Diseases
 Hematologic Diseases Antibodies  >11 publications with IL-16 and Hematologic Diseases
 Fibrosis Antibodies  >7 publications with IL-16 and Fibrosis
 Liver Diseases Antibodies  >7 publications with IL-16 and Liver Diseases
 Kidney Diseases Antibodies  >5 publications with IL-16 and Kidney Diseases
 Lung Neoplasms Antibodies  >5 publications with IL-16 and Lung Neoplasms
 Breast Neoplasms Antibodies  >5 publications with IL-16 and Breast Neoplasms

Organs/Tissues associated with IL-16 active protein

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >333 publications with IL-16 and Blood
 Lung Antibodies  >52 publications with IL-16 and Lung
 Skin Antibodies  >30 publications with IL-16 and Skin
 Brain Antibodies  >24 publications with IL-16 and Brain
 Lymph Node Antibodies  >16 publications with IL-16 and Lymph Node
 Lymph Antibodies  >16 publications with IL-16 and Lymph
 Liver Antibodies  >12 publications with IL-16 and Liver
 Bone Marrow Antibodies  >10 publications with IL-16 and Bone Marrow
 Spleen Antibodies  >9 publications with IL-16 and Spleen
 Intestine Antibodies  >9 publications with IL-16 and Intestine
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