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OX40/TNFRSF4 Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS201358

TNFRSF4, also known as tumor necrosis factor receptor superfamily member 4, is a T cell co-stimulatory molecule in the TNF receptor superfamily. This protein coordinates with other co-stimulatory substances (CD28, CD40, CD30, CD27 and 4-1BB) to control the… More details

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Product Overview

Online Datasheet in PDF
Product Name
OX40/TNFRSF4, Active Protein
Full Product Name
Recombinant human OX40/TNFRSF4 protein
Product Gene Name
OX40/TNFRSF4 active protein
Product Synonym Names
Tumor necrosis factor receptor superfamily member 4; TNFRSF4; ACT35; CD134; IMD16; OX40; TXGP1L; ACT35 antigen; OX40L receptor; TAX transcriptionally-activated glycoprotein 1 receptor
Sequence
LHCVGDTYPS NDRCCHECRP GNGMVSRCSR SQNTVCRPCG PGFYNDVVSS KPCKPCTWCN LRSGSERKQL CTATQDTVCR CRAGTQPLDS YKPGVDCAPC PPGHFSPGDN QACKPWTNCT LAGKHTLQPA SNSSDAICED RDPPATQPQE TQGPPARPIT VQPTEAWPRT SQGPSTRPVE VPGGRA
Host
Baculovirus
Form/Format
Liquid. In Phosphate-Buffered Saline (pH7.4) containing 10% glycerol
Purity/Purification
>90% by SDS-PAGE
Concentration
0.5mg/ml (determined by absorbance at 280nm) (lot specific)
Preparation and Storage
Can be stored at +2C to +8 degree C for 1 week. For long term storage, aliquot and store at -20C to -80 degree C. Avoid repeated freezing and thawing cycles.
Molecular Weight
29,341 Da
Sequence Positions
29-214aa
OMIM
gene 615593
3D Structure
ModBase 3D Structure for P43489
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Endotoxin
<1 EU per 1ug of protein (determined by LAL method)
Species
Human
Tag
hIgG-His-Tag
Predicted N-term
Leu29
Bioactivity
Measured by its binding ability in a functional ELISA with mouse OX40 Ligand/TNFSF4. The ED50 range <= 0.15ug/ml.

Product Categories/Family for OX40/TNFRSF4 active protein

Immunology; Proteins
Applications Tested/Suitable for OX40/TNFRSF4 active protein
SDS-PAGE, Bioactivity

SDS-Page of OX40/TNFRSF4 active protein

3ug by SDS-PAGE under reducing condition and visualized by coomassie blue stain.
OX40/TNFRSF4 Active Protein – Cat# MBS201358

Biological Activity of OX40/TNFRSF4 active protein

Mouse OX40 Ligand/TNFSF4 (CAT# ATGP4022) is coated at 1 ug/ml (100 ul/well) can bind Human TNFRSF4. The ED50 range <= 0.15 ug/ml.
OX40/TNFRSF4 Active Protein, Biological Activity – Cat# MBS201358

Product References and Citations for OX40/TNFRSF4 active protein

Hori, T., et al. (2006) Int. J. Hematol. 83:17-22. Moran, A.E., et al. (2013) Curr. Opin. Immunol. 25:230-237.

Other Notes

Small volumes of OX40/TNFRSF4 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for OX40/TNFRSF4 purchase

MBS201358 is an active protein targeting OX40/TNFRSF4. Also known as Recombinant human OX40/TNFRSF4 protein. Host: Baculovirus.

Additional Details

NCBI/Uniprot data below describe general gene information for OX40/TNFRSF4. It may not necessarily be applicable to this product.

NCBI GI #
4507579
NCBI GeneID
7293
NCBI Accession #
NP_003318.1
UniProt Primary Accession #
P43489
UniProt Secondary Accession #
Q13663; Q2M312; Q5T7M0
UniProt Related Accession #
P43489
GenBank Nucleotide #
NM_003327.3
NCBI Official Full Name
tumor necrosis factor receptor superfamily member 4
NCBI Official Synonym Full Names
TNF receptor superfamily member 4
NCBI Official Symbol
TNFRSF4
NCBI Official Synonym Symbols
OX40; ACT35; CD134; IMD16; TXGP1L
UniProt Protein Name
Tumor necrosis factor receptor superfamily member 4
UniProt Synonym Protein Names
ACT35 antigen; OX40L receptor; TAX transcriptionally-activated glycoprotein 1 receptor; CD_antigen: CD134
UniProt Gene Name
TNFRSF4
UniProt Synonym Gene Names
TXGP1L
UniProt Entry Name
TNR4_HUMAN
NCBI Protein Information
tumor necrosis factor receptor superfamily member 4

NCBI Summary for OX40/TNFRSF4

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation. [provided by RefSeq, Jul 2008]
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UniProt Comments for OX40/TNFRSF4

TNFRSF4: Receptor for TNFSF4/OX40L/GP34.

Protein type: Apoptosis; Receptor, misc.; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1p36

Cellular Component: cell surface; integral to plasma membrane; external side of plasma membrane

Molecular Function: tumor necrosis factor receptor activity

Biological Process: T cell proliferation; regulation of apoptosis; tumor necrosis factor-mediated signaling pathway; negative regulation of transcription factor activity; negative regulation of cytokine secretion; positive regulation of B cell proliferation; cellular defense response; immune response; positive regulation of immunoglobulin secretion; negative regulation of transcription, DNA-dependent; inflammatory response; regulation of protein kinase activity

Disease: Immunodeficiency 16
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Research Articles on OX40/TNFRSF4

1. Increased OX40 expression is associated with gastric cancer.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with OX40/TNFRSF4 active protein

 Products by Pathway  Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Downstream Signaling In Naive CD8+ T Cells Pathway antibodies  Downstream Signaling In Naive CD8+ T Cells Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 TNFR2 Non-canonical NF-kB Pathway antibodies  TNFR2 Non-canonical NF-kB Pathway Diagram
 TNFs Bind Their Physiological Receptors Pathway antibodies  TNFs Bind Their Physiological Receptors Pathway Diagram

Diseases associated with OX40/TNFRSF4 active protein

 Disease Name  Pubmed Publications
 Necrosis Antibodies  >300 publications with OX40/TNFRSF4 and Necrosis
 Autoimmune Diseases Antibodies  >64 publications with OX40/TNFRSF4 and Autoimmune Diseases
 Disease Models, Animal Antibodies  >61 publications with OX40/TNFRSF4 and Disease Models, Animal
 Inflammation Antibodies  >52 publications with OX40/TNFRSF4 and Inflammation
 Lung Diseases Antibodies  >24 publications with OX40/TNFRSF4 and Lung Diseases
 Nervous System Diseases Antibodies  >24 publications with OX40/TNFRSF4 and Nervous System Diseases
 Neoplasms, Experimental Antibodies  >22 publications with OX40/TNFRSF4 and Neoplasms, Experimental
 Cardiovascular Diseases Antibodies  >22 publications with OX40/TNFRSF4 and Cardiovascular Diseases
 Brain Diseases Antibodies  >15 publications with OX40/TNFRSF4 and Brain Diseases
 Atherosclerosis Antibodies  >12 publications with OX40/TNFRSF4 and Atherosclerosis

Organs/Tissues associated with OX40/TNFRSF4 active protein

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >361 publications with OX40/TNFRSF4 and Blood
 Lymph Node Antibodies  >48 publications with OX40/TNFRSF4 and Lymph Node
 Lung Antibodies  >24 publications with OX40/TNFRSF4 and Lung
 Skin Antibodies  >23 publications with OX40/TNFRSF4 and Skin
 Intestine Antibodies  >8 publications with OX40/TNFRSF4 and Intestine
 Kidney Antibodies  >6 publications with OX40/TNFRSF4 and Kidney
 Stomach Antibodies  >1 publications with OX40/TNFRSF4 and Stomach
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