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Prolactin (PRL) Rat Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS142199

Description: Prolactin Rat Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 198 amino acids and having a molecular mass of 22.6 kDa. The Prolactin is purified by proprietary chromatographic techniques.Introduction:… More details

$250 / 0.01 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Prolactin (Prl), Active Protein
Full Product Name
Recombinant Rat Prolactin
Product Gene Name
Prl active protein
Product Synonym Names
Prolactin Rat; Prolactin Rat Recombinant; Mammotropin; Luterotropic hormone; Lutetropin; PRL; rProlactin
Sequence
The sequence of the first five N-terminal amino acids was determined and was found to be Met-Leu-Pr o-Val-Cys
Host
E Coli
Form/Format
The protein was lyophilized from a concentrated (1mg/ml) solution with 10mM sodium Phosphate buffer pH=8 and 50mM Nacl.
Sterile Filtered White lyophilized (freeze-dried) powder.
Purity/Purification
Greater than 95.0% as determined by: (a) Analysis by SEC-HPLC. (b) Analysis by SDS-PAGE.
Preparation and Storage
Lyophilized Prolactin although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution Prolactin should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
Molecular Weight
25,753 Da
3D Structure
ModBase 3D Structure for P01237
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Solubility
It is recommended to reconstitute the lyophilized Prolactin in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
Biological Activity
The ED50 as determined by the dose-dependant stimulation of the proliferation of rat lymphoma, Nb2-11 was found to be < 0.065 ng/ml corresponding to a specific activity of 15,400,000 Units/mg.

Product Categories/Family for Prl active protein

Cytokines and Growth Factors; Growth Factors; Prolactin

Other Notes

Small volumes of Prl active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Prl purchase

MBS142199 is an active protein targeting Prl. Also known as Recombinant Rat Prolactin. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for Prl. It may not necessarily be applicable to this product.

NCBI GI #
6981404
NCBI GeneID
24683
NCBI Accession #
NP_036761.1
UniProt Primary Accession #
P01237
UniProt Secondary Accession #
P70520
UniProt Related Accession #
P01237
GenBank Nucleotide #
NM_012629.1
NCBI Official Full Name
prolactin
NCBI Official Synonym Full Names
prolactin
NCBI Official Symbol
Prl
NCBI Official Synonym Symbols
PRLB; Prol; PRLSD1; Prl1a1; RNPROL; RATPRLSD1
UniProt Protein Name
Prolactin
Protein Family
Prolactin
UniProt Gene Name
Prl
UniProt Synonym Gene Names
PRL
UniProt Entry Name
PRL_RAT
NCBI Protein Information
prolactin; prolactin family 1, subfamily a, member 1

NCBI Summary for Prl

induces lactation; may facilitate decidual growth and placentation; promotes prostate epithelial cell proliferation [RGD, Feb 2006]

UniProt Comments for Prl

prolactin: Prolactin acts primarily on the mammary gland by promoting lactation. Belongs to the somatotropin/prolactin family.

Protein type: Motility/polarity/chemotaxis; Secreted; Cytokine; Secreted, signal peptide

Cellular Component: extracellular region; secretory granule

Molecular Function: prolactin receptor binding; hormone activity

Biological Process: response to drug; circadian rhythm; lactation; maternal behavior; regulation of multicellular organism growth; positive regulation of JAK-STAT cascade; response to lipopolysaccharide; response to organic cyclic substance; response to estradiol stimulus; cellular response to hormone stimulus; regulation of JAK-STAT cascade; ovulation cycle; response to ethanol; mammary gland development; positive regulation of cell proliferation; parturition; regulation of ossification; multicellular organismal response to stress; positive regulation of epithelial cell proliferation; response to nutrient; STAT protein nuclear translocation
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Research Articles on Prl

1. Prolactin induces apoptosis of lactotropes

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with Prl active protein

 Products by Pathway  Pathway Diagram
 Amyloids Pathway antibodies  Amyloids Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Growth Hormone Receptor Signaling Pathway antibodies  Growth Hormone Receptor Signaling Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram

Diseases associated with Prl active protein

 Disease Name  Pubmed Publications
 Pituitary Neoplasms Antibodies  >2026 publications with Prl and Pituitary Neoplasms
 Hyperprolactinemia Antibodies  >1520 publications with Prl and Hyperprolactinemia
 Adenoma Antibodies  >1489 publications with Prl and Adenoma
 Prolactinoma Antibodies  >677 publications with Prl and Prolactinoma
 Mental Disorders Antibodies  >606 publications with Prl and Mental Disorders
 Amenorrhea Antibodies  >427 publications with Prl and Amenorrhea
 Galactorrhea Antibodies  >316 publications with Prl and Galactorrhea
 Growth Hormone-Secreting Pituitary Adenoma Antibodies  >265 publications with Prl and Growth Hormone-Secreting Pituitary Adenoma
 Infertility, Female Antibodies  >235 publications with Prl and Infertility, Female
 Hypogonadism Antibodies  >207 publications with Prl and Hypogonadism

Organs/Tissues associated with Prl active protein

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >5126 publications with Prl and Brain
 Pituitary Gland Antibodies  >3989 publications with Prl and Pituitary Gland
 Inner Ear Antibodies  >2 publications with Prl and Inner Ear
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