Fabesetron

98%

Powder: -20 degree C for 3 years
In solvent: -80 degree C for 2 years

129300-27-2

<1mg/ml refers to the product slightly soluble or insoluble

Fabesetron (FK1052)(0.1 mg/kg p.o.) inhibits completely the increases in the colonic transit[1]. FK1052 (100 ug/kg) completely prevents emesis induced by cisplatin (18mg/kg, i.p.) in Suncus murinus[2]. Animal Model: Male Sprague-Dawley rats weighing 220 to 330 g and male ddy mice weighing 25 to 35 g were used[1]. Dosage: 0.1 mg/kg. Administration: P.O. Result: Significantly caused delay and its degree of inhibition was 33.8 +/- 4.8% by 0.1 mg/kg p.o. Animal Model: Suncus murinus of either sex (10-week-old; 30-70 g body weight)[2]. Dosage: 1, 10, and 100 ug/kg. Administration: Orally administered 30 min before the injection of cisplatin. Result: Inhibited cisplatininduced emesis in a dose-dependent manner, and no emesis was observed in three animals given the compound at 100 ug/kg.