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Necrosulfonamide

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3601482

A small molecule covalent inhibitor of mixed lineage kinase domain like protein (MLKL) that specifically blocks necrosis downstream of RIP3 activation. More details

$235 / 5 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Necrosulfonamide, Biochemical
Full Product Name
Necrosulfonamide
Purity/Purification
>98% (HPLC)
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Molecular Weight
461.4716
Suitability
DMSO: >=28mg/mL
Target
MLK
Receptor
necrosis (MLKL)
Chemical Name
2-Propenamide, N-[4-[[(3-methoxy-2-pyrazinyl)amino]sulfonyl]phenyl]-3-(5-nitro-2-thienyl)-, (2E)
SMILES
COC1=NC=CN=C1NS(=O)(=O)C2=CC=C(C=C2)NC(=O)/C=C/C3=CC=C(S3)[N+](=O)[O-]
Molecular Formula
C18H15N5O6S2
CAS Number
1360614-48-7

Product Categories/Family for Necrosulfonamide biochemical

MAPK/ERK Signaling; Cancer

Structure of Necrosulfonamide biochemical

Necrosulfonamide Biochemical – Cat# MBS3601482

Product References and Citations for Necrosulfonamide biochemical

1. Sun L, et al. Cell. 2012 Jan 20; 148 (1-2):213-27.
2. Mulay SR, et al. Nat Commun. 2016 Jan 28; 7:10274.
3. Chen S, et al. Apoptosis. 2017 May; 22 (5):626-638.

Other Notes

Small volumes of Necrosulfonamide biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Necrosulfonamide purchase

MBS3601482 is a biochemical targeting Necrosulfonamide.
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