DCK Antibody (C-Term) Blocking Peptide

Name: DCK Antibody (C-Term) Blocking Peptide; MyBioSource
Brand: MyBioSource
SKU: MBS9226574
Price: 455 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9226574

Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential… More details

$455 / 0.5 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

DCK, Blocking Peptide

Full Product Name

DCK Antibody (C-term) Blocking Peptide

Product Gene Name

DCK blocking peptide

Product Synonym Names

Deoxycytidine kinase; dCK; DCK

Form/Format

The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.

Specificity

The synthetic peptide sequence used to generate the antibody was selected from the C-term region of human DCK. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.

Preparation and Storage

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Antibody/Peptide Pairs

DCK peptide (MBS9226574) is used for blocking the activity of DCK antibody (MBS9202756)

Molecular Weight

30,519 Da

OMIM

125450

Cellular Location

Nucleus.

Other Notes

Small volumes of DCK blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DCK purchase

MBS9226574 is a blocking peptide targeting DCK. Also known as DCK Antibody (C-term) Blocking Peptide.

Additional Details

NCBI/Uniprot data below describe general gene information for DCK. It may not necessarily be applicable to this product.

NCBI GI #

118447

NCBI GeneID

1633

NCBI Accession #

P27707.1

UniProt Primary Accession #

P27707

UniProt Secondary Accession #

Q5TZY7; Q6FI11; B2R8V6

UniProt Related Accession #

P27707

NCBI Official Full Name

Deoxycytidine kinase

NCBI Official Synonym Full Names

deoxycytidine kinase

NCBI Official Symbol

DCK

UniProt Protein Name

Deoxycytidine kinase

Protein Family

Deoxyadenosine/deoxycytidine kinase

UniProt Gene Name

DCK

UniProt Synonym Gene Names

dCK

UniProt Entry Name

DCK_HUMAN

NCBI Protein Information

deoxycytidine kinase

NCBI Summary for DCK

Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents. Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. DCK is clinically important because of its relationship to drug resistance and sensitivity. [provided by RefSeq, Jul 2008]

UniProt Comments for DCK

DCK: Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents. Belongs to the DCK/DGK family.

Protein type: EC 2.7.1.74; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; Kinase, other

Chromosomal Location of Human Ortholog: 4q13.3-q21.1

Cellular Component: cytosol; nucleus

Molecular Function: deoxycytidine kinase activity; drug binding; nucleoside kinase activity; protein homodimerization activity

Biological Process: purine salvage; pyrimidine nucleoside salvage; pyrimidine nucleotide metabolic process

Research Articles on DCK

1. recently described a human deoxycytidine kinase mutant (G12) that sensitizes cancer cell lines to treatment with gemcitabine. Here, starting from the G12 variant, we identified a mutant that triggers even greater sensitisation to gemcitabine than G12.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with DCK blocking peptide

Reference Product	PubMed Publications
CDA blocking peptide	>82 publications with DCK and CDA
NT5C2 blocking peptide	>9 publications with DCK and NT5C2
DCTD blocking peptide	>7 publications with DCK and DCTD
NT5C3 blocking peptide	>3 publications with DCK and NT5C3
APRT blocking peptide	>2 publications with DCK and APRT
CMPK1 blocking peptide	>1 publications with DCK and CMPK1

Pathways associated with DCK blocking peptide

Products by Pathway	Pathway Diagram
Metabolic Pathways antibodies	Metabolic Pathways Diagram
Metabolism Pathway antibodies	Metabolism Pathway Diagram
Metabolism Of Nucleotides Pathway antibodies	Metabolism Of Nucleotides Pathway Diagram
Purine Metabolism Pathway antibodies	Purine Metabolism Pathway Diagram
Purine Metabolism Pathway antibodies	Purine Metabolism Pathway Diagram
Purine Metabolism Pathway antibodies	Purine Metabolism Pathway Diagram
Purine Salvage Pathway antibodies	Purine Salvage Pathway Diagram
Pyrimidine Metabolism Pathway antibodies	Pyrimidine Metabolism Pathway Diagram
Pyrimidine Metabolism Pathway antibodies	Pyrimidine Metabolism Pathway Diagram
Pyrimidine Metabolism Pathway antibodies	Pyrimidine Metabolism Pathway Diagram

Diseases associated with DCK blocking peptide

Disease Name	Pubmed Publications
Carcinoma Antibodies	>65 publications with DCK and Carcinoma
Pancreatic Neoplasms Antibodies	>45 publications with DCK and Pancreatic Neoplasms
Lung Neoplasms Antibodies	>30 publications with DCK and Lung Neoplasms
Neoplasms, Experimental Antibodies	>26 publications with DCK and Neoplasms, Experimental
Disease Models, Animal Antibodies	>15 publications with DCK and Disease Models, Animal
Ovarian Neoplasms Antibodies	>11 publications with DCK and Ovarian Neoplasms
Breast Neoplasms Antibodies	>7 publications with DCK and Breast Neoplasms
Urinary Bladder Neoplasms Antibodies	>6 publications with DCK and Urinary Bladder Neoplasms
Liver Neoplasms Antibodies	>5 publications with DCK and Liver Neoplasms
Carcinoma, Hepatocellular Antibodies	>4 publications with DCK and Carcinoma, Hepatocellular

Organs/Tissues associated with DCK blocking peptide

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>112 publications with DCK and Blood
Lung Antibodies	>43 publications with DCK and Lung
Brain Antibodies	>26 publications with DCK and Brain
Liver Antibodies	>23 publications with DCK and Liver
Bone Marrow Antibodies	>23 publications with DCK and Bone Marrow
Spleen Antibodies	>15 publications with DCK and Spleen
Lymph Antibodies	>10 publications with DCK and Lymph
Lymph Node Antibodies	>10 publications with DCK and Lymph Node
Pancreas Antibodies	>9 publications with DCK and Pancreas
Bladder Antibodies	>8 publications with DCK and Bladder