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CD38 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9206190

CD38 is a novel multifunctional ectoenzyme widely expressed in cells and tissues especially in leukocytes. CD38 also functions in cell adhesion,signal transduction and calcium signaling. More details

$240 / 0.08 mL +1 FREE 8GB USB
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Testing Data View PDF
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Product Overview

Online Datasheet in PDF
Product Name
CD38, Polyclonal Antibody
Full Product Name
CD38 Antibody (C-term)
Product Gene Name
anti-CD38 antibody
Product Synonym Names
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1; 2'-phospho-ADP-ribosyl cyclase; 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase; 2'-phospho-cyclic-ADP-ribose transferase; ADP-ribosyl cyclase 1; ADPRC 1; Cyclic ADP-ribose hydrolase 1; cADPr hydrolase 1; T10; CD38; CD38
Clonality
Polyclonal
Isotype
Rabbit Ig
Host
Rabbit
Species Reactivity
Human (Predicted Reactivity: Monkey)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Purity/Purification
Purified Rabbit Polyclonal Antibody (Pab)
Concentration
Vial Concentration: 2 (lot specific)
Specificity
This CD38 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 241-270 amino acids from the C-terminal region of human CD38.
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Antibody/Peptide Pairs
CD38 peptide (MBS9224910) is used for blocking the activity of CD38 antibody (MBS9206190)
Molecular Weight
34328
Immunogen Sequence Positions
241-270
OMIM
107270
3D Structure
ModBase 3D Structure for P28907
Antigen Type
Synthetic Peptide
Crown Antibody
Yes
Antigen Source
HUMAN

Product Categories/Family for anti-CD38 antibody

Crown Antibodies; Cancer; Immunology; Neuroscience; Signal Transduction
Applications Tested/Suitable for anti-CD38 antibody
Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FC/FACS)
Application Notes for anti-CD38 antibody
WB~~1:1000

Western Blot (WB) of anti-CD38 antibody

Western blot analysis of lysate from 293T cell line, using CD38 Antibody (C-term). MBS9206190 was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody. Lysate at 20ug.
Rabbit Anti-CD38 Polyclonal Antibody – Cat# MBS9206190

Western Blot (WB) of anti-CD38 antibody

Western blot analysis of lysate from RPMI8226 cell line, using CD38 Antibody (C-term). MBS9206190 was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody. Lysate at 20ug.
Rabbit Anti-CD38 Polyclonal Antibody, Western Blot (WB) – Cat# MBS9206190

Immunohistochemistry (IHC) of anti-CD38 antibody

Formalin-fixed and paraffin-embedded human hepatocarcinoma with CD38 Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Rabbit Anti-CD38 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS9206190

Immunofluorescence (IF) of anti-CD38 antibody

Immunofluorescence analysis of CD38 Antibody (C-term) with paraffin-embedded human hepatocarcinoma tissue. 0.05 mg/ml primary antibody was followed by FITC-conjugated goat anti-rabbit lgG (whole molecule). FITC emits green fluorescence.Red counterstaining is PI.
Rabbit Anti-CD38 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS9206190

Flow Cytometry (FC/FACS) of anti-CD38 antibody

Flow cytometric analysis of HepG2 cells using CD38 Antibody (C-term)(bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-CD38 Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS9206190

Immunofluorescence (IF) of anti-CD38 antibody

Confocal immunofluorescent analysis of CD38 Antibody (C-term) with Hela cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).
Rabbit Anti-CD38 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS9206190

Immunofluorescence (IF) of anti-CD38 antibody

Western blot analysis of lysate from RPMI 8226 cell line, using CD38 Antibody (C-term). MBS9206190 was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody. Lysate at 35ug.
Rabbit Anti-CD38 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS9206190

Product References and Citations for anti-CD38 antibody

Horenstein,A.L., Mol. Med. 15 (3-4), 76-84 (2009) Liu,Q., Biochemistry 47 (52), 13966-13973 (2008) Liu,Q., Chem. Biol. 15 (10), 1068-1078 (2008)

Other Notes

Small volumes of anti-CD38 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD38 purchase

MBS9206190 is an antibody targeting CD38. Also known as CD38 Antibody (C-term). Reactive in Human (Predicted Reactivity: Monkey). Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CD38. It may not necessarily be applicable to this product.

NCBI GI #
38454326
NCBI GeneID
952
NCBI Accession #
NP_001766.2
UniProt Primary Accession #
P28907
UniProt Secondary Accession #
O00121; O00122; Q96HY4
UniProt Related Accession #
P28907
GenBank Nucleotide #
NM_001775.2
NCBI Official Full Name
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
NCBI Official Synonym Full Names
CD38 molecule
NCBI Official Symbol
CD38
NCBI Official Synonym Symbols
T10; ADPRC 1
UniProt Protein Name
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
UniProt Synonym Protein Names
2'-phospho-ADP-ribosyl cyclase; 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase (EC:2.4.99.20); 2'-phospho-cyclic-ADP-ribose transferase; ADP-ribosyl cyclase 1; ADPRC 1; Cyclic ADP-ribose hydrolase 1; cADPr hydrolase 1; T10; CD_antigen: CD38
Protein Family
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase
UniProt Gene Name
CD38
UniProt Synonym Gene Names
ADPRC 1; cADPr hydrolase 1
UniProt Entry Name
CD38_HUMAN
NCBI Protein Information
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1

UniProt Comments for CD38

CD38: Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system. Belongs to the ADP-ribosyl cyclase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Lyase; Hydrolase; EC 2.4.99.20; Cofactor and Vitamin Metabolism - nicotinate and nicotinamide; Cell surface; EC 3.2.2.6; Cell cycle regulation; Apoptosis

Chromosomal Location of Human Ortholog: 4p15

Cellular Component: cell surface; membrane; plasma membrane; integral to membrane; nucleus

Molecular Function: transferase activity; phosphorus-oxygen lyase activity; NAD+ nucleosidase activity; NAD(P)+ nucleosidase activity

Biological Process: response to drug; response to retinoic acid; metabolic process; positive regulation of transcription, DNA-dependent; positive regulation of insulin secretion; female pregnancy; signal transduction; positive regulation of cell growth; response to estradiol stimulus; elevation of cytosolic calcium ion concentration; B cell receptor signaling pathway; response to hydroperoxide; positive regulation of B cell proliferation; positive regulation of vasoconstriction; response to hypoxia; response to progesterone stimulus; negative regulation of bone resorption; negative regulation of transcription, DNA-dependent; negative regulation of apoptosis
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Research Articles on CD38

1. CD38 expression is regulated by micro-RNA 708 in airway smooth muscle cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CD38 antibody

 Reference Product  PubMed Publications
 CD4 antibody  >1183 publications with CD38 and CD4
 ZAP70 antibody  >240 publications with CD38 and ZAP70
 LCK antibody  >8 publications with CD38 and LCK
 BST1 antibody  >3 publications with CD38 and BST1
 ENPP1 antibody  >1 publications with CD38 and ENPP1
 CD8A antibody  >1 publications with CD38 and CD8A

Pathways associated with anti-CD38 antibody

 Products by Pathway  Pathway Diagram
 Nucleotide Excision Repair Pathway antibodies  Nucleotide Excision Repair Pathway Diagram
 Nucleotide Excision Repair Pathway antibodies  Nucleotide Excision Repair Pathway Diagram
 Nucleotide Excision Repair Pathway antibodies  Nucleotide Excision Repair Pathway Diagram
 Nucleotide Excision Repair Pathway antibodies  Nucleotide Excision Repair Pathway Diagram
 Nucleotide Excision Repair Pathway antibodies  Nucleotide Excision Repair Pathway Diagram
 Nucleotide Excision Repair Pathway antibodies  Nucleotide Excision Repair Pathway Diagram
 Nucleotide Excision Repair Pathway antibodies  Nucleotide Excision Repair Pathway Diagram
 Nucleotide Excision Repair Pathway antibodies  Nucleotide Excision Repair Pathway Diagram
 Nucleotide Excision Repair Pathway antibodies  Nucleotide Excision Repair Pathway Diagram
 Nucleotide Excision Repair Pathway antibodies  Nucleotide Excision Repair Pathway Diagram

Diseases associated with anti-CD38 antibody

 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >448 publications with CD38 and Cardiovascular Diseases
 Inflammation Antibodies  >278 publications with CD38 and Inflammation
 Necrosis Antibodies  >200 publications with CD38 and Necrosis
 Liver Diseases Antibodies  >103 publications with CD38 and Liver Diseases
 Nervous System Diseases Antibodies  >103 publications with CD38 and Nervous System Diseases
 Anemia Antibodies  >96 publications with CD38 and Anemia
 Neoplasms, Experimental Antibodies  >77 publications with CD38 and Neoplasms, Experimental
 Disease Models, Animal Antibodies  >73 publications with CD38 and Disease Models, Animal
 Breast Neoplasms Antibodies  >44 publications with CD38 and Breast Neoplasms
 Pain Antibodies  >31 publications with CD38 and Pain

Organs/Tissues associated with anti-CD38 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >3782 publications with CD38 and Blood
 Bone Marrow Antibodies  >1387 publications with CD38 and Bone Marrow
 Lymph Node Antibodies  >280 publications with CD38 and Lymph Node
 Liver Antibodies  >221 publications with CD38 and Liver
 Lymph Antibodies  >208 publications with CD38 and Lymph
 Spleen Antibodies  >167 publications with CD38 and Spleen
 Muscle Antibodies  >136 publications with CD38 and Muscle
 Brain Antibodies  >125 publications with CD38 and Brain
 Tonsil Antibodies  >113 publications with CD38 and Tonsil
 Pharynx Antibodies  >107 publications with CD38 and Pharynx
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