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DDX6 Antibody Antigenic Blocking Peptide

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS543581

Antigenic Blocking Peptide Probable ATP-dependent RNA helicase DDX6 AntibodyIn the process of mRNA degradation, may play a role in mRNA decapping. More details

$315 / 0.25 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
DDX6, Blocking Peptide
Full Product Name
DDX6 Antibody Antigenic Blocking Peptide
Product Gene Name
DDX6 blocking peptide
Product Synonym Names
ATP dependent RNA helicase DDX6; ATP dependent RNA helicase p54; DDX6; DEAD (Asp Glu Ala Asp) box polypeptide 6; DEAD box 6; DEAD box protein 6; DEAD/H (Asp Glu Ala Asp/His) box polypeptide 6 (RNA helicase 54kD); FLJ36338; HLR2; Oncogene RCK; P54; Probable ATP-dependent RNA helicase DDX6; RCK antibody
Form/Format
Antigenic Blocking Peptide
Concentration
Quantity: 250 ug; Volume: 100 ul (lot specific)
Preparation and Storage
-20 degree C for long term storage
Antibody/Peptide Pairs
DDX6 peptide (MBS543581) is used for blocking the activity of DDX6 antibody (MBS540905)
Antibody/Peptide Pairs
DDX6 peptide (MBS543581) is used for blocking the activity of DDX6 antibody (MBS541410)
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Molecular Weight
54,417 Da
OMIM
600326
Immunogen
Synthetic Peptide
Expression
Abundantly expressed in most tissues.
Molecular Function
ATP-binding, Nucleotide-binding, RNA-binding
Structure
Forms a complex with DCP1A, DCP2, EDC3 and EDC4/HEDLS. Interacts with LIMD1, WTIP and AJUBA. Interacts with APOBEC3G in an RNA-dependent manner. Interacts with RC3H1 (By similarity).
Subcellular Location
Cytoplasm; P-body
Applications Tested/Suitable for DDX6 blocking peptide
Immunodepletion, Immunocompetition
Application Notes for DDX6 blocking peptide
Western Blot: 1:500

Other Notes

Small volumes of DDX6 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DDX6 purchase

MBS543581 is a blocking peptide targeting DDX6. Also known as DDX6 Antibody Antigenic Blocking Peptide.

Additional Details

NCBI/Uniprot data below describe general gene information for DDX6. It may not necessarily be applicable to this product.

NCBI GI #
164664518
NCBI GeneID
1656
NCBI Accession #
NP_004388.2
UniProt Primary Accession #
P26196
UniProt Secondary Accession #
Q5D048
UniProt Related Accession #
P26196
GenBank Nucleotide #
NM_004397.5
NCBI Official Full Name
probable ATP-dependent RNA helicase DDX6
NCBI Official Synonym Full Names
DEAD-box helicase 6
NCBI Official Symbol
DDX6
NCBI Official Synonym Symbols
P54; RCK; HLR2
UniProt Protein Name
Probable ATP-dependent RNA helicase DDX6
UniProt Synonym Protein Names
ATP-dependent RNA helicase p54; DEAD box protein 6; Oncogene RCK
Protein Family
ATP-dependent RNA helicase
UniProt Gene Name
DDX6
UniProt Synonym Gene Names
HLR2; RCK
UniProt Entry Name
DDX6_HUMAN
NCBI Protein Information
probable ATP-dependent RNA helicase DDX6

NCBI Summary for DDX6

This gene encodes a member of the DEAD box protein family. The protein is an RNA helicase found in P-bodies and stress granules, and functions in translation suppression and mRNA degradation. It is required for microRNA-induced gene silencing. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Mar 2012]
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UniProt Comments for DDX6

DDX6: an oncogenic ATP-dependent helicase of the DEAD box family. Interacts with argonaute proteins, Ago1 and Ago2, and is a general repressor of translation in human cells by miRNA-induced gene silencing. In the process of mRNA degradation, may play a role in mRNA decapping.

Protein type: EC 3.6.4.13; Helicase; RNA processing; RNA-binding; Oncoprotein

Chromosomal Location of Human Ortholog: 11q23.3

Cellular Component: cytoplasm; cytosol; intracellular membrane-bound organelle; membrane; stress granule

Molecular Function: ATP binding; ATP-dependent RNA helicase activity; helicase activity; protein binding; protein domain specific binding; RNA helicase activity

Biological Process: cytoplasmic mRNA processing body assembly; negative regulation of neuron differentiation; regulation of translation; RNA secondary structure unwinding; stem cell maintenance; viral RNA genome packaging
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Research Articles on DDX6

1. DDX6 repression complexes are required for P-body assembly.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with DDX6 blocking peptide

 Reference Product  PubMed Publications
 DCP2 blocking peptide  >12 publications with DDX6 and DCP2
 PATL1 blocking peptide  >6 publications with DDX6 and PATL1
 EDC3 blocking peptide  >6 publications with DDX6 and EDC3
 CNOT1 blocking peptide  >5 publications with DDX6 and CNOT1
 LSM14A blocking peptide  >4 publications with DDX6 and LSM14A
 LSM7 blocking peptide  >1 publications with DDX6 and LSM7
 DCP1B blocking peptide  >1 publications with DDX6 and DCP1B
 ATXN2 blocking peptide  >1 publications with DDX6 and ATXN2
 LSM14B blocking peptide  >1 publications with DDX6 and LSM14B

Pathways associated with DDX6 blocking peptide

 Products by Pathway  Pathway Diagram
 Deadenylation-dependent MRNA Decay Pathway antibodies  Deadenylation-dependent MRNA Decay Pathway Diagram
 Decapping Complex Pathway antibodies  Decapping Complex Pathway Diagram
 Decapping Complex Pathway antibodies  Decapping Complex Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 RNA Degradation Pathway antibodies  RNA Degradation Pathway Diagram
 RNA Degradation Pathway antibodies  RNA Degradation Pathway Diagram
 MRNA Decay By 5' To 3' Exoribonuclease Pathway antibodies  MRNA Decay By 5' To 3' Exoribonuclease Pathway Diagram

Diseases associated with DDX6 blocking peptide

 Disease Name  Pubmed Publications
 Adenocarcinoma Antibodies  >6 publications with DDX6 and Adenocarcinoma
 Cell Transformation, Neoplastic Antibodies  >5 publications with DDX6 and Cell Transformation, Neoplastic
 Nervous System Diseases Antibodies  >4 publications with DDX6 and Nervous System Diseases
 Liver Diseases Antibodies  >4 publications with DDX6 and Liver Diseases
 Carcinoma, Hepatocellular Antibodies  >3 publications with DDX6 and Carcinoma, Hepatocellular
 Liver Neoplasms Antibodies  >3 publications with DDX6 and Liver Neoplasms
 Fever Antibodies  >3 publications with DDX6 and Fever
 Brain Diseases Antibodies  >3 publications with DDX6 and Brain Diseases
 Arthritis, Rheumatoid Antibodies  >3 publications with DDX6 and Arthritis, Rheumatoid
 Necrosis Antibodies  >2 publications with DDX6 and Necrosis

Organs/Tissues associated with DDX6 blocking peptide

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >13 publications with DDX6 and Blood
 Brain Antibodies  >7 publications with DDX6 and Brain
 Nerve Antibodies  >5 publications with DDX6 and Nerve
 Liver Antibodies  >5 publications with DDX6 and Liver
 Testis Antibodies  >4 publications with DDX6 and Testis
 Ovary Antibodies  >4 publications with DDX6 and Ovary
 Muscle Antibodies  >2 publications with DDX6 and Muscle
 Skin Antibodies  >1 publications with DDX6 and Skin
 Vascular Antibodies  >1 publications with DDX6 and Vascular
 Mouth Antibodies  >1 publications with DDX6 and Mouth
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