EDN2 Antibody (C-Term) Blocking Peptide

This gene encodes a member of the endothelin protein family of secretory vasoconstrictive peptides. The preproprotein is processed to a short mature form which functions as a ligand for the endothelin receptors that initiate intracellular signaling events. This gene product is involved in a wide range of biological processes, such as hypertension and ovulation. Altered expression of this gene is implicated in tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]

EDN2: Endothelins are endothelium-derived vasoconstrictor peptides. Belongs to the endothelin/sarafotoxin family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 1p34

Cellular Component: extracellular region; extracellular space

Molecular Function: endothelin B receptor binding; hormone activity

Biological Process: artery smooth muscle contraction; calcium-mediated signaling; cell surface receptor linked signal transduction; cytokine and chemokine mediated signaling pathway; elevation of cytosolic calcium ion concentration; hormonal regulation of the force of heart contraction; inositol phosphate-mediated signaling; macrophage activation; macrophage chemotaxis; neutrophil chemotaxis; positive regulation of cell proliferation; positive regulation of heart rate; positive regulation of leukocyte chemotaxis; positive regulation of the force of heart contraction by chemical signal; prostaglandin biosynthetic process; regulation of systemic arterial blood pressure by endothelin; vasoconstriction; vein smooth muscle contraction