EDN2 Antibody – Rabbit Polyclonal

This gene encodes a member of the endothelin protein family of secretory vasoconstrictive peptides. The preproprotein is processed to a short mature form which functions as a ligand for the endothelin receptors that initiate intracellular signaling events. This gene product is involved in a wide range of biological processes, such as hypertension and ovulation. Altered expression of this gene is implicated in tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]

EDN2: Endothelins are endothelium-derived vasoconstrictor peptides. Belongs to the endothelin/sarafotoxin family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 1p34

Cellular Component: extracellular space; extracellular region

Molecular Function: hormone activity

Biological Process: neutrophil chemotaxis; vasoconstriction; inositol phosphate-mediated signaling; regulation of systemic arterial blood pressure by endothelin; cytokine and chemokine mediated signaling pathway; positive regulation of the force of heart contraction by chemical signal; calcium-mediated signaling; positive regulation of leukocyte chemotaxis; positive regulation of heart rate; thermoregulation; vein smooth muscle contraction; hormonal regulation of the force of heart contraction; prostaglandin biosynthetic process; macrophage chemotaxis; macrophage activation; elevation of cytosolic calcium ion concentration; cell surface receptor linked signal transduction; regulation of vasoconstriction; positive regulation of cell proliferation; positive regulation of smooth muscle contraction; alveolus development; artery smooth muscle contraction