FKBP14 Blocking Peptide – Cat# MBS9621720

FKBP14 Blocking Peptide – The purity is >90%,tested by HPLC and MS. Purity

Name: FKBP14 Blocking Peptide; The purity is >90%,tested by HPLC and MS. Purity; MyBioSource
Brand: MyBioSource
SKU: MBS9621720
Price: 460 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9621720

Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the… More details

$460 / 1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

FKBP14, Blocking Peptide

Full Product Name

FKBP14 Blocking Peptide

Product Gene Name

FKBP14 blocking peptide

Product Synonym Names

22 kDa FK506 binding protein; 22 kDa FK506-binding protein; 22 kDa FKBP; FK506 binding protein 14 (22 kDa); FK506 binding protein 14; FK506-binding protein 14; FKB14_HUMAN; FKBP 22; FKBP-14; FKBP-22; FKBP14; FKBP22; FLJ20731; Peptidyl prolyl cis trans isomerase; Peptidyl-prolyl cis-trans isomerase FKBP14; PPIase; PPIase FKBP14; Rotamase

Form/Format

Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.

Purity/Purification

The purity is >90%,tested by HPLC and MS.

Preparation and Storage

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Antibody/Peptide Pairs

FKBP14 peptide (MBS9621720) is used for blocking the activity of FKBP14 antibody (MBS9611767)

Molecular Weight

24,172 Da

OMIM

614505

Supply Chain Verification

Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available, please inquire.

Notes

For phospho antibody, we provide phospho peptide (0.5mg) and non-phospho peptide (0.5mg)

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Applications Tested/Suitable for FKBP14 blocking peptide

Blocking/Control

Other Notes

Small volumes of FKBP14 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FKBP14 purchase

MBS9621720 is a blocking peptide targeting FKBP14.

Additional Details

NCBI/Uniprot data below describe general gene information for FKBP14. It may not necessarily be applicable to this product.

NCBI GI #

23821568

NCBI GeneID

55033

NCBI Accession #

Q9NWM8.1

UniProt Primary Accession #

Q9NWM8

UniProt Related Accession #

Q9NWM8

NCBI Official Full Name

Peptidyl-prolyl cis-trans isomerase FKBP14

NCBI Official Synonym Full Names

FK506 binding protein 14, 22 kDa

NCBI Official Symbol

FKBP14

NCBI Official Synonym Symbols

EDSKMH; FKBP22; IPBP12

UniProt Protein Name

Peptidyl-prolyl cis-trans isomerase FKBP14

UniProt Synonym Protein Names

22 kDa FK506-binding protein; 22 kDa FKBP; FKBP-22; FK506-binding protein 14; FKBP-14; Rotamase

Protein Family

Peptidyl-prolyl cis-trans isomerase

UniProt Gene Name

FKBP14

UniProt Synonym Gene Names

FKBP22; PPIase FKBP14; 22 kDa FKBP; FKBP-22; FKBP-14

UniProt Entry Name

FKB14_HUMAN

NCBI Protein Information

peptidyl-prolyl cis-trans isomerase FKBP14; FKBP-22; rotamase; 22 kDa FKBP; PPIase FKBP14; FK506-binding protein 14; 22 kDa FK506-binding protein

NCBI Summary for FKBP14

The protein encoded by this gene is a member of the FK506-binding protein family of peptidyl-prolyl cis-trans isomerases. The encoded protein is found in the lumen of the endoplasmic reticulum, where it is thought to accelerate protein folding. Defects in this gene are a cause of a type of Ehlers-Danlos syndrome (EDS). Both a protein-coding variant and noncoding variants are transcribed from this gene. [provided by RefSeq, Mar 2012]

UniProt Comments for FKBP14

FKBP14: PPIases accelerate the folding of proteins during protein synthesis. Defects in FKBP14 are the cause of Ehlers-Danlos syndrome with progressive kyphoscoliosis, myopathy, and hearing loss (EDSKMH). A syndrome with features of Ehlers-Danlos syndrome types VIA and VIB on the one hand, and the collagen VI- related congenital myopathies Ullrich congenital muscular dystrophy and Bethlem myopathy on the other hand. Clinically, this disorder is characterized by the following features: severe generalized hypotonia at birth with marked muscle weakness that improve in infancy; early-onset progressive kyphoscoliosis; joint hypermobility without contractures; hyperelastic skin with follicular hyperkeratosis, easy bruising, and occasional abnormal scarring; myopathy as confirmed by muscle MRI, histology, and electron microscopy; hearing impairment, which is predominantly sensorineural; and a normal ratio of lysyl pyridinoline to hydroxylysyl pyridinoline (LP/HP) in urine.

Protein type: Secreted, signal peptide; Secreted; Isomerase; EC 5.2.1.8

Chromosomal Location of Human Ortholog: 7p14.3

Cellular Component: endoplasmic reticulum membrane; endoplasmic reticulum lumen

Molecular Function: FK506 binding; peptidyl-prolyl cis-trans isomerase activity; calcium ion binding

Biological Process: protein peptidyl-prolyl isomerization; unfolded protein response, activation of signaling protein activity; cellular protein metabolic process; unfolded protein response

Disease: Ehlers-danlos Syndrome With Progressive Kyphoscoliosis, Myopathy, And Hearing Loss

Research Articles on FKBP14

1. A 1.9 A resolution crystal structure for human FKBP22 has been determined. The EF-hand motifs of two FKBP22 molecules form a dimeric complex with an elongated and predominantly hydrophobic cavity that can potentially be occupied by an aliphatic ligand.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with FKBP14 blocking peptide

Products by Pathway	Pathway Diagram
IRE1alpha Activates Chaperones Pathway antibodies	IRE1alpha Activates Chaperones Pathway Diagram
Metabolism Of Proteins Pathway antibodies	Metabolism Of Proteins Pathway Diagram
Unfolded Protein Response (UPR) Pathway antibodies	Unfolded Protein Response (UPR) Pathway Diagram
XBP1(S) Activates Chaperone Genes Pathway antibodies	XBP1(S) Activates Chaperone Genes Pathway Diagram

Diseases associated with FKBP14 blocking peptide

Disease Name	Pubmed Publications
Congenital Abnormalities Antibodies	>2 publications with FKBP14 and Congenital Abnormalities
Abnormalities, Multiple Antibodies	>2 publications with FKBP14 and Abnormalities, Multiple
Neoplasms Antibodies	>1 publications with FKBP14 and Neoplasms

Organs/Tissues associated with FKBP14 blocking peptide

Organ/Tissue Name	Pubmed Publications
Skin Antibodies	>2 publications with FKBP14 and Skin
Connective Tissue Antibodies	>1 publications with FKBP14 and Connective Tissue
Vascular Antibodies	>1 publications with FKBP14 and Vascular
Lung Antibodies	>1 publications with FKBP14 and Lung
Eye Antibodies	>1 publications with FKBP14 and Eye