HAND1 Blocking Peptide (N-Term) Blocking Peptide

The protein encoded by this gene belongs to the basic helix-loop-helix family of transcription factors. This gene product is one of two closely related family members, the HAND proteins, which are asymmetrically expressed in the developing ventricular chambers and play an essential role in cardiac morphogenesis. Working in a complementary fashion, they function in the formation of the right ventricle and aortic arch arteries, implicating them as mediators of congenital heart disease. In addition, it has been suggested that this transcription factor may be required for early trophoblast differentiation. [provided by RefSeq, Jul 2008]

HAND1: Transcription factor that plays an essential role in both trophoblast-giant cells differentiation and in cardiac morphogenesis. In the adult, could be required for ongoing expression of cardiac-specific genes. Binds the DNA sequence 5'- NRTCTG-3' (non-canonical E-box).

Protein type: Transcription factor; Nucleolus; Cell development/differentiation; DNA-binding

Chromosomal Location of Human Ortholog: 5q33

Cellular Component: cytoplasm; nucleus

Molecular Function: bHLH transcription factor binding; identical protein binding; protein binding; transcription coactivator activity; transcription corepressor activity; transcription factor binding

Biological Process: angiogenesis; blastocyst development; embryonic heart tube development; heart development; heart looping; negative regulation of transcription factor activity; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; transcription from RNA polymerase II promoter; trophectodermal cell differentiation; ventricular cardiac muscle morphogenesis