HHEX Blocking Peptide

HHEX: Recognizes the DNA sequence 5'-ATTAA-3'. Transcriptional repressor. May play a role in hematopoietic differentiation. Establishes anterior identity at two levels; acts early to enhance canonical WNT-signaling by repressing expression of TLE4, and acts later to inhibit NODAL-signaling by directly targeting NODAL.

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 10q23.33

Cellular Component: cytoplasm; nucleus

Molecular Function: protein binding; protein homodimerization activity; TATA-binding protein binding; sequence-specific DNA binding; eukaryotic initiation factor 4E binding; chromatin binding; transcription factor binding; DNA bending activity

Biological Process: response to peptide hormone stimulus; negative regulation of transcription from RNA polymerase II promoter; anterior/posterior pattern formation; poly(A)+ mRNA export from nucleus; pancreas development; thyroid gland development; response to wounding; cell differentiation; vasculogenesis; positive regulation of Wnt receptor signaling pathway; Wnt receptor signaling pathway; negative regulation of vascular endothelial growth factor receptor signaling pathway; transcription, DNA-dependent; in utero embryonic development; multicellular organism growth; negative regulation of cyclin-dependent protein kinase activity; forebrain morphogenesis; interkinetic nuclear migration; regulation of cell proliferation; cell proliferation; negative regulation of angiogenesis; mRNA export from nucleus; B cell differentiation; myeloid leukocyte differentiation; embryonic heart tube development; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; endoderm development