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ID3 Antibody (C-Term) Blocking Peptide

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9223347

Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a… More details

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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
ID3, Blocking Peptide
Full Product Name
ID3 Antibody (C-term) Blocking Peptide
Product Gene Name
ID3 blocking peptide
Product Synonym Gene Name
1R21; BHLHB25; HEIR1
Product Synonym Names
DNA-binding protein inhibitor ID-3; Class B basic helix-loop-helix protein 25; bHLHb25; Helix-loop-helix protein HEIR-1; ID-like protein inhibitor HLH 1R21; Inhibitor of DNA binding 3; Inhibitor of differentiation 3; ID3; 1R21; BHLHB25; HEIR1
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Antibody/Peptide Pairs
ID3 peptide (MBS9223347) is used for blocking the activity of ID3 antibody (MBS9210031)
Molecular Weight
12,999 Da
OMIM
600277
Cellular Location
Nucleus.
Tissue Location
Expressed abundantly in lung, kidney and adrenal gland, but not in adult brain

Other Notes

Small volumes of ID3 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ID3 purchase

MBS9223347 is a blocking peptide targeting ID3. Also known as ID3 Antibody (C-term) Blocking Peptide.

Additional Details

NCBI/Uniprot data below describe general gene information for ID3. It may not necessarily be applicable to this product.

NCBI GI #
322510035
NCBI GeneID
3399
NCBI Accession #
Q02535.2
UniProt Primary Accession #
Q02535
UniProt Secondary Accession #
O75641; A8K1T8
UniProt Related Accession #
Q02535
NCBI Official Full Name
DNA-binding protein inhibitor ID-3
NCBI Official Synonym Full Names
inhibitor of DNA binding 3, HLH protein
NCBI Official Symbol
ID3
NCBI Official Synonym Symbols
HEIR-1; bHLHb25
UniProt Protein Name
DNA-binding protein inhibitor ID-3
UniProt Synonym Protein Names
Class B basic helix-loop-helix protein 25; bHLHb25; Helix-loop-helix protein HEIR-1; ID-like protein inhibitor HLH 1R21; Inhibitor of DNA binding 3; Inhibitor of differentiation 3
Protein Family
DNA-binding protein inhibitor
UniProt Gene Name
ID3
UniProt Synonym Gene Names
1R21; BHLHB25; HEIR1; bHLHb25
UniProt Entry Name
ID3_HUMAN
NCBI Protein Information
DNA-binding protein inhibitor ID-3

NCBI Summary for ID3

The protein encoded by this gene is a helix-loop-helix (HLH) protein that can form heterodimers with other HLH proteins. However, the encoded protein lacks a basic DNA-binding domain and therefore inhibits the DNA binding of any HLH protein with which it interacts. [provided by RefSeq, Aug 2011]

UniProt Comments for ID3

ID3: ID (inhibitor of DNA binding) HLH proteins lack a basic DNA-binding domain but are able to form heterodimers with other HLH proteins, thereby inhibiting DNA binding. ID-3 inhibits the binding of E2A-containing protein complexes to muscle creatine kinase E-box enhancer. May inhibit other transcription factors. Induced by phorbol 12-myristate 13-acetate (PMA). Interacts with COPS5 and COPS7A. Homodimer, and heterodimer with other HLH proteins.

Protein type: Transcription, coactivator/corepressor; DNA-binding

Chromosomal Location of Human Ortholog: 1p36.13-p36.12

Cellular Component: microtubule cytoskeleton; nucleoplasm; nucleus

Molecular Function: protein binding; transcription corepressor activity

Biological Process: multicellular organismal development; negative regulation of transcription factor activity; negative regulation of transcription, DNA-dependent
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Research Articles on ID3

1. Upon Id3 transfection, A549 cells displayed decreased migratory and invasive capabilities, however, co-transfection of miRId3 and Id3 into A549 cells reversed the Id3-induced inhibitions of migratory and invasive capabilities.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with ID3 blocking peptide

 Reference Product  PubMed Publications
 TCF3 blocking peptide  >49 publications with ID3 and TCF3
 TCF12 blocking peptide  >11 publications with ID3 and TCF12
 HES1 blocking peptide  >10 publications with ID3 and HES1
 TCF4 blocking peptide  >6 publications with ID3 and TCF4
 CDK2 blocking peptide  >3 publications with ID3 and CDK2
 MYOD1 blocking peptide  >3 publications with ID3 and MYOD1
 NKX2-5 blocking peptide  >2 publications with ID3 and NKX2-5
 ZNF238 blocking peptide  >2 publications with ID3 and ZNF238

Pathways associated with ID3 blocking peptide

 Products by Pathway  Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Id Signaling Pathway antibodies  Id Signaling Pathway Diagram
 Signaling Pathways Regulating Pluripotency Of Stem Cells antibodies  Signaling Pathways Regulating Pluripotency Of Stem Cells Diagram
 Signaling Pathways Regulating Pluripotency Of Stem Cells antibodies  Signaling Pathways Regulating Pluripotency Of Stem Cells Diagram
 TGF-beta Signaling Pathway antibodies  TGF-beta Signaling Pathway Diagram
 TGF-beta Signaling Pathway antibodies  TGF-beta Signaling Pathway Diagram

Diseases associated with ID3 blocking peptide

 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >40 publications with ID3 and Carcinoma
 Nervous System Diseases Antibodies  >29 publications with ID3 and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >25 publications with ID3 and Cardiovascular Diseases
 Brain Diseases Antibodies  >24 publications with ID3 and Brain Diseases
 Burkitt Lymphoma Antibodies  >22 publications with ID3 and Burkitt Lymphoma
 Adenocarcinoma Antibodies  >20 publications with ID3 and Adenocarcinoma
 Inflammation Antibodies  >19 publications with ID3 and Inflammation
 Breast Neoplasms Antibodies  >18 publications with ID3 and Breast Neoplasms
 Prostatic Neoplasms Antibodies  >18 publications with ID3 and Prostatic Neoplasms
 Lung Neoplasms Antibodies  >16 publications with ID3 and Lung Neoplasms

Organs/Tissues associated with ID3 blocking peptide

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >149 publications with ID3 and Blood
 Bone Antibodies  >112 publications with ID3 and Bone
 Muscle Antibodies  >76 publications with ID3 and Muscle
 Vascular Antibodies  >65 publications with ID3 and Vascular
 Brain Antibodies  >57 publications with ID3 and Brain
 Embryonic Tissue Antibodies  >49 publications with ID3 and Embryonic Tissue
 Lung Antibodies  >38 publications with ID3 and Lung
 Thymus Antibodies  >29 publications with ID3 and Thymus
 Nerve Antibodies  >27 publications with ID3 and Nerve
 Bone Marrow Antibodies  >26 publications with ID3 and Bone Marrow
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