M CCNB1 Blocking Peptide (Center S123/S125) Blocking Peptide

CCNB1: a member of the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Complexes with cdc2 to form the maturation-promoting factor (MPF). Two alternatively spliced isoforms have been found, a constitutively expressed form and a cell cycle-regulated form that is expressed predominantly during G2/M phase.

Protein type: Cell cycle regulation; Activator

Cellular Component: centrosome; cytoplasm; membrane; nucleus; spindle pole

Molecular Function: histone kinase activity; kinase activity; patched binding; protein binding; protein complex binding; protein kinase binding

Biological Process: in utero embryonic development; mitotic metaphase plate congression; mitotic spindle organization and biogenesis; negative regulation of protein amino acid phosphorylation; oocyte maturation; positive regulation of attachment of spindle microtubules to kinetochore; positive regulation of cardiac muscle cell proliferation; positive regulation of cell cycle; positive regulation of fibroblast proliferation; positive regulation of histone phosphorylation; positive regulation of mitotic cell cycle; positive regulation of mRNA 3'-end processing; protein amino acid phosphorylation; protein complex assembly