RFC3 Antibody (Center) Blocking Peptide

The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1, is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kDa. This gene encodes the 38 kDa subunit. This subunit is essential for the interaction between the 140 kDa subunit and the core complex that consists of the 36, 37, and 40 kDa subunits. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

RFC3: The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. Belongs to the activator 1 small subunits family.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 13q13.2

Cellular Component: DNA replication factor C complex; nucleoplasm

Molecular Function: ATPase activity; DNA binding; DNA clamp loader activity; protein binding; single-stranded DNA-dependent ATPase activity

Biological Process: bypass DNA synthesis; DNA damage response, detection of DNA damage; DNA replication; DNA strand elongation during DNA replication; DNA synthesis during DNA repair; error-prone postreplication DNA repair; nucleotide-excision repair, DNA gap filling; nucleotide-excision repair, DNA incision; nucleotide-excision repair, DNA incision, 5'-to lesion; response to organophosphorus; telomere maintenance via recombination; transcription-coupled nucleotide-excision repair