SPNS2 Peptide - N-Terminal Region Blocking Peptide

Name: SPNS2 Peptide - N-Terminal Region Blocking Peptide; MyBioSource
Brand: MyBioSource
SKU: MBS3237487
Price: 195 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3237487

This is a synthetic peptide designed for use in combination with anti-SPNS2 antibody madeTarget Description: SPNS2 is the sphingolipid transporter required for migration of myocardial precursors. SPNS2 transports sphingosine 1-phosphate (S1P), a secreted… More details

$195 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

SPNS2, Blocking Peptide

Full Product Name

SPNS2 Peptide - N-terminal region

Product Gene Name

SPNS2 blocking peptide

Form/Format

Lyophilized powder

Preparation and Storage

Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20 degree C. Avoid repeat freeze-thaw cycles.

Antibody/Peptide Pairs

SPNS2 peptide (MBS3237487) is used for blocking the activity of SPNS2 antibody (MBS3212540)

Molecular Weight

60kDa

OMIM

612584

Product Categories/Family for SPNS2 blocking peptide

Peptide

Applications Tested/Suitable for SPNS2 blocking peptide

Western Blot (WB)

Other Notes

Small volumes of SPNS2 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SPNS2 purchase

MBS3237487 is a blocking peptide targeting SPNS2. Also known as SPNS2 Peptide - N-terminal region.

Additional Details

NCBI/Uniprot data below describe general gene information for SPNS2. It may not necessarily be applicable to this product.

NCBI GI #

185136021

NCBI GeneID

124976

NCBI Accession #

NP_001118230

UniProt Primary Accession #

Q8IVW8

UniProt Related Accession #

Q8IVW8

GenBank Nucleotide #

NM_001124758

NCBI Official Full Name

protein spinster homolog 2

NCBI Official Synonym Full Names

sphingolipid transporter 2

NCBI Official Symbol

SPNS2

UniProt Protein Name

Protein spinster homolog 2

Protein Family

Protein spinster

UniProt Gene Name

SPNS2

UniProt Entry Name

SPNS2_HUMAN

NCBI Protein Information

protein spinster homolog 2

NCBI Summary for SPNS2

The protein encoded by this gene is a transporter of sphingosine 1-phosphate, a secreted lipid that is important in cardiovascular, immunological, and neural development. Defects in this gene are a cause of early onset progressive hearing loss. [provided by RefSeq, Jul 2016]

UniProt Comments for SPNS2

SPNS2: Sphingolipid transporter required for migration of myocardial precursors. Transports sphingosine 1-phosphate (S1P), a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. Mediates the export of S1P from cells in the extraembryonic yolk syncytial layer (YSL), thereby regulating myocardial precursor migration. Belongs to the major facilitator (TC 2.A.1) superfamily. Spinster (TC 2.A.1.49) family.

Protein type: Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 17p13.2

Cellular Component: integral to membrane; lysosomal membrane; vesicle

Molecular Function: sphingolipid transporter activity

Biological Process: B cell homeostasis; lipid transport; locomotion; lymph node development; regulation of eye pigmentation; regulation of humoral immune response; sphingolipid metabolic process; T cell homeostasis; transmembrane transport

Research Articles on SPNS2

1. our data demonstrate that Spns2 and S1P have a crucial effect on proximal tubular epithelial cells by regulating an inflammatory process and a subsequent fibrotic reaction, and also by influencing other tubular transporters that are involved in the pathophysiology of inflammatory and fibrotic kidney diseases.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with SPNS2 blocking peptide

Disease Name	Pubmed Publications
Cardiovascular Diseases Antibodies	>2 publications with SPNS2 and Cardiovascular Diseases
Congenital Abnormalities Antibodies	>2 publications with SPNS2 and Congenital Abnormalities
Heart Diseases Antibodies	>1 publications with SPNS2 and Heart Diseases
Heart Defects, Congenital Antibodies	>1 publications with SPNS2 and Heart Defects, Congenital

Organs/Tissues associated with SPNS2 blocking peptide

Organ/Tissue Name	Pubmed Publications
Bone Antibodies	>3 publications with SPNS2 and Bone
Blood Antibodies	>3 publications with SPNS2 and Blood
Bone Marrow Antibodies	>2 publications with SPNS2 and Bone Marrow
Heart Antibodies	>2 publications with SPNS2 and Heart