SYN3 Peptide - Middle Region Blocking Peptide

This gene is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. The protein encoded by this gene shares the synapsin family domain model, with domains A, C, and E exhibiting the highest degree of conservation. The protein contains a unique domain J, located between domains C and E. Based on this gene's localization to 22q12.3, a possible schizophrenia susceptibility locus, and the established neurobiological roles of the synapsins, this family member may represent a candidate gene for schizophrenia. The TIMP3 gene is located within an intron of this gene and is transcribed in the opposite direction. Alternative splicing of this gene results in multiple splice variants that encode different isoforms. [provided by RefSeq, Oct 2008]

SYN3: neuronal phosphoprotein that may be involved in the regulation of neurotransmitter release and synaptogenesis. Binds ATP with high affinity and ADP with a lower affinity. This is consistent with a catalytic role of the C-domain in which ADP would be dissociated by cellular ATP after bound ATP was hydrolyzed. May represent a candidate gene for schizophrenia. Alternative splicing results in six variants; however, only three isoforms have been fully described.

Protein type: Vesicle

Chromosomal Location of Human Ortholog: 22q12.3

Cellular Component: synaptic vesicle; synaptic vesicle membrane; cell junction

Molecular Function: catalytic activity; ATP binding

Biological Process: metabolic process; neurotransmitter secretion; regulation of synaptic transmission, GABAergic