Complement Component 4 (C4) ELISA Kit for Cat

Name: Cat C4 ELISA Kit; Complement Component 4; MyBioSource
Brand: MyBioSource
SKU: MBS059961
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS059961

MBS059961 is a ready-to-use microwell, strip-or-full plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Complement Component 4 (C4) ELISA Kit target analytes in biological samples. The concentration gradients of the kit… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

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Product Overview

Online Datasheet in PDF

Product Name

Complement Component 4 (C4), ELISA Kit

Full Product Name

Cat Complement Component 4 ELISA Kit

Product Gene Name

C4 elisa kit

Species Reactivity

Cat

Preparation and Storage

Store all reagents at 2-8 degree C

Molecular Weight

67,033 Da

OMIM

120830

3D Structure

ModBase 3D Structure for P04003

Other Notes

Small volumes of C4 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for C4. It may not necessarily be applicable to this product.

NCBI GI #

119613909

NCBI GeneID

722

NCBI Accession #

EAW93503.1

UniProt Primary Accession #

P04003

UniProt Secondary Accession #

Q5VVQ8

UniProt Related Accession #

P04003

NCBI Official Full Name

complement component 4 binding protein, alpha, isoform CRA_c

NCBI Official Synonym Full Names

complement component 4 binding protein, alpha

NCBI Official Symbol

C4BPA

NCBI Official Synonym Symbols

PRP; C4BP

UniProt Protein Name

C4b-binding protein alpha chain

UniProt Synonym Protein Names

Proline-rich protein

Protein Family

Complement C4

UniProt Gene Name

C4BPA

UniProt Synonym Gene Names

C4BP; C4bp; PRP

UniProt Entry Name

C4BPA_HUMAN

NCBI Protein Information

C4b-binding protein alpha chain; proline-rich protein

NCBI Summary for C4

This gene encodes a member of a superfamily of proteins composed predominantly of tandemly arrayed short consensus repeats of approximately 60 amino acids. Along with a single, unique beta-chain, seven identical alpha-chains encoded by this gene assemble into the predominant isoform of C4b-binding protein, a multimeric protein that controls activation of the complement cascade through the classical pathway. The genes encoding both alpha and beta chains are located adjacent to each other on human chromosome 1 in the regulator of complement activation gene cluster. Two pseudogenes of this gene are also found in the cluster. [provided by RefSeq, Jul 2008]

UniProt Comments for C4

C4BPA: Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with anticoagulant protein S and with serum amyloid P component.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 1q32

Cellular Component: extracellular space; extracellular region; plasma membrane

Molecular Function: protein binding

Biological Process: negative regulation of complement activation, classical pathway; regulation of complement activation; positive regulation of protein catabolic process; innate immune response; complement activation, classical pathway

Research Articles on C4

1. these data suggest that when C4BP is bound to Ail, fI can cleave and inactivate C4b that has bound covalently to bacterial surface structures as well as C4b bound noncovalently to Ail.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with C4 elisa kit

Reference Product	PubMed Publications
C4B elisa kit	>77 publications with C4 and C4B
C4BPB elisa kit	>21 publications with C4 and C4BPB
PROS1 elisa kit	>2 publications with C4 and PROS1
APCS elisa kit	>2 publications with C4 and APCS
CFI elisa kit	>2 publications with C4 and CFI
CD40 elisa kit	>1 publications with C4 and CD40

Pathways associated with C4 elisa kit

Products by Pathway	Pathway Diagram
CD40/CD40L Signaling Pathway antibodies	CD40/CD40L Signaling Pathway Diagram
Complement And Coagulation Cascades Pathway antibodies	Complement And Coagulation Cascades Pathway Diagram
Complement And Coagulation Cascades Pathway antibodies	Complement And Coagulation Cascades Pathway Diagram
Complement Cascade Pathway antibodies	Complement Cascade Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
Innate Immune System Pathway antibodies	Innate Immune System Pathway Diagram
Pertussis Pathway antibodies	Pertussis Pathway Diagram
Pertussis Pathway antibodies	Pertussis Pathway Diagram
Regulation Of Complement Cascade Pathway antibodies	Regulation Of Complement Cascade Pathway Diagram

Diseases associated with C4 elisa kit

Disease Name	Pubmed Publications
Inflammation Antibodies	>8 publications with C4 and Inflammation
Cardiovascular Diseases Antibodies	>5 publications with C4 and Cardiovascular Diseases
Autoimmune Diseases Antibodies	>5 publications with C4 and Autoimmune Diseases
Blood Coagulation Disorders Antibodies	>4 publications with C4 and Blood Coagulation Disorders
Carcinoma, Hepatocellular Antibodies	>4 publications with C4 and Carcinoma, Hepatocellular
Liver Diseases Antibodies	>4 publications with C4 and Liver Diseases
Liver Neoplasms Antibodies	>3 publications with C4 and Liver Neoplasms
Necrosis Antibodies	>3 publications with C4 and Necrosis
Lung Diseases Antibodies	>3 publications with C4 and Lung Diseases
Lung Neoplasms Antibodies	>2 publications with C4 and Lung Neoplasms

Organs/Tissues associated with C4 elisa kit

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>41 publications with C4 and Blood
Liver Antibodies	>6 publications with C4 and Liver
Uterus Antibodies	>4 publications with C4 and Uterus
Lung Antibodies	>3 publications with C4 and Lung
Muscle Antibodies	>2 publications with C4 and Muscle
Brain Antibodies	>2 publications with C4 and Brain
Intestine Antibodies	>1 publications with C4 and Intestine
Connective Tissue Antibodies	>1 publications with C4 and Connective Tissue
Mammary Gland Antibodies	>1 publications with C4 and Mammary Gland