Human AMBRA1 cDNA Clone Expression Plasmid – Cat# MBS1270313

AMBRA1 cDNA Clone – Autophagy/Beclin-1 Regulator 1 (Human)

Name: AMBRA1 cDNA Clone; Autophagy/Beclin-1 Regulator 1; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1270313
Price: 1560 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1270313

MBS1270313 is a cDNA clone targeting AMBRA1. More details

$1560 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

AMBRA1, cDNA Clone

Full Product Name

AMBRA1 cDNA Clone

Product Gene Name

AMBRA1 cdna clone

Sequence

atgaaggttg tcccagaaaa gaatgctgtc cggatactct gggggcgaga acggggtgct cgggccatgg gagctcagcg gcttctgcag gagctggtag aggataaaac ccggtggatg aaatgggagg gcaagagagt agaactgccg gatagtccac gctctacctt cttattggcc ttcagcccag acaggactct cttagcctcc acccatgtga accataatat ctatattacg gaggtgaaga ctggcaagtg tgttcattcc ctgattggac accgccgtac tccatggtgt gtcacttttc atcccaccat ctcaggcctt attgcttctg gctgcctaga tggggaggtt aggatttggg atttacacgg tggcagtgaa agctggttca cagatagcaa caatgccatt gcctccctgg ctttccaccc tacggctcag ctcctgctga ttgccactgc caatgagatc cacttctggg actggagtcg acgggaaccc tttgctgtgg tgaagacagc tagtgagatg gaacgggtcc gtctggtgag atttgatcca cttggacact acttactcac agcaattgtt aacccctcta atcaacaggg tgatgacgaa ccagagatcc ccatagatgg aacagaatta tcccactacc gtcagcgtgc cctcctgcaa tcacagccag ttcgccggac gcctctcctc cacaatttcc tgcacatgct gtcctcccgc tcttctggca tccagaccga gcccttccat cccccggagc aggcctcgtc aacgcagcag gaccagggcc tcctgaaccg gccgtctgcc ttcagtacag tccagagcag cactgccggc aacacgctcc gcaacctcag tctgggtcct acccgccgct ctttgggagg gcctctgtct agccaccctt ctaggtatca ccgagaaata gctcctgggt tgacaggatc tgagtggacc cggacagtac tcagtctgaa ctcccgctct gaggcggaat ccatgccccc gcccagaacc agtgcctctt cggtgagttt gctgtctgtg ctgagacagc aggaaggtgg ctctcaggca tctgtgtaca cttcagccac agaagggagg ggttttccgg catcagggtt ggcaactgag tcagatggag ggaatggctc cagccaaaac aactcgggca gcattcgcca tgagcttcag tgtgacctga gacgcttctt tctggagtat gaccggcttc aggagctgga tcagagcctg agtggggaag ctccccagac ccaacaggcc caggaaatgc tcaacaataa cattgaatct gagaggccag gcccttccca ccagcccacc ccacacagca gtgagaacaa ctccaacctg tcccgtggcc acctgaatcg ctgtcgtgct tgccacaatc tcctgacctt caacaacgat accctgcgct gggaaagaac cacacctaac tactcctctg gcgaggctag ttcctcttgg caggtcccca gctcctttga gagtgtgcca tcaagtggca gccagttgcc acctctcgag cggactgagg gccaaacgcc cagctccagc aggctggagt tgagcagctc tgctagtccg caggaggaga ggactgtggg ggtggccttt aaccaggaga caggccactg ggaaagaatt tacacccagt ccagcagatc tggaactgtg tcacaggagg ccttacatca ggatatgcct gaggagagct ctgaggagga ttcactcagg aggaggctgc tggaatcttc cctcatttca ttatcccgtt atgatggagc aggatccaga gagcacccaa tttacccaga cccagcgaga ttatctcctg ctgcatacta cgcccagagg atgatccagt atctctcacg gagagacagt attcgccagc gctccatgcg ctaccaacag aaccgtctcc gttcttccac ctcctcctct tcctcagaca accagggtcc atcagtagag ggaaccgact tggaatttga ggactttgag gacaatggtg acagatccag gcaccgagct ccacgcaatg cccggatgtc tgcaccttcg cttggacgct ttgtcccaag gcgtttcttg ctgcctgagt acttgcctta tgctgggatt tttcatgaac gtggacagcc tggcttggct actcactctt ctgttaacag ggtcctggca ggggcagtga tcggtgatgg acagtctgct gtggccagta acattgccaa tactacctac cggctccagt ggtgggactt cactaagttt gacctccctg aaatcagtaa tgcttccgtg aatgtgctgg tgcagaactg caagatctac aatgatgcca gctgtgacat ttctgcagat ggccagctcc tggcagcttt catccccagc agccagaggg gctttcctga tgaaggcatc ctggcagtgt actccctggc cccccataac ctgggcgaaa tgctctacac caagcgattt ggtcccaatg ccatttcggt gagcctgtcc ccaatgggca gatatgtaat ggtgggcttg gcctcacgaa ggatcctgct gcacccctcc acagagcaca tggtggccca ggtcttcagg ctgcaacagg cccatggtgg agagacctcc atgaggagag ttttcaacgt cctttatccc atgcctgccg accagcggag acatgtcagt atcaactctg cccgttggct gcctgagcca gggcttggct tggcctatgg tactaacaaa ggagacctgg tgatctgccg accagaggcc ttaaactctg gtgttgagta ctactgggac cagctgaacg agacggtctt cactgtccat tccaacagca ggagcagcga gcggcctgga accagcagag ccacatggag gacagacaga gacatggggc tgatgaatgc cattgggctt cagccccgga accctgccac ctcagtgaca tctcagggca ccgagactct ggcccttcag ctgcagaatg ccgaaacaca gactgagagg gaggtgccgg agccagggac agccgcctca ggtcctggtg aaggtgaggg ttcagagtat ggtgccagtg gagaagatgc gctcagcagg atccagaggc tgatggcgga gggcggcatg acagccgtgg tgcagcggga gcagagcacc accatggcct ccatgggcgg cttcggcaac aacatcatcg tcagccaccg cattcaccgc agctctcaga cgggcactga acctggtgcc gcccacacct cctcacccca gccctccacc tctcggggac tgctcccaga ggccgggcaa ctggcagagc gaggcctaag cccccggaca gcttcctggg accagcctgg tacccctggg cgggagccaa cccagccaac cctgccctct tcctcccctg tccccattcc tgtttccctt cccagcgctg agggaccaac cgtccactgc gagttgacca ataacaacca ccttctggat ggtggcagca gcagggggga cgctgcaggc cctaggggag aaccacggaa caggtag

Molecular Weight

84,428 Da

OMIM

611359

Vector

pUC

Clone Sequence Report

Provided with product shipment

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of AMBRA1 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for AMBRA1. It may not necessarily be applicable to this product.

NCBI GI #

28277035

NCBI GeneID

55626

NCBI Accession #

BC045609

UniProt Secondary Accession #

Q86XD6; Q9H8Z0; Q9NXE7; A6XN33; D3DQP8; G3V193

UniProt Related Accession #

Q9C0C7

NCBI Official Full Name

Homo sapiens autophagy/beclin-1 regulator 1, mRNA

NCBI Official Synonym Full Names

autophagy and beclin 1 regulator 1

NCBI Official Symbol

AMBRA1

NCBI Official Synonym Symbols

DCAF3; WDR94

UniProt Protein Name

Activating molecule in BECN1-regulated autophagy protein 1

Protein Family

Activating molecule in BECN1-regulated autophagy protein

UniProt Gene Name

AMBRA1

UniProt Synonym Gene Names

KIAA1736

UniProt Entry Name

AMRA1_HUMAN

NCBI Protein Information

activating molecule in BECN1-regulated autophagy protein 1

UniProt Comments for AMBRA1

AMBRA1: a WD40 protein that regulates autophagy and development of the nervous system. A highly conserved vertebrate protein whose expression is mostly confined to the neuroepithelium during early neurogenesis. Involved in autophagy in controlling protein turnover during neuronal development, and in regulating normal cell survival and proliferation. Interacts with ATG6. Forms a complex with ATG6 and PIK3C3. Its functional inactivation in mouse is lethal in utero (starting from embryonic day 14.5), leading to severe neural tube defects associated with autophagy impairment, accumulation of ubiquitinated proteins, and excessive apoptosis. Hyperproliferation followed by a wave of caspase-dependent cell death was the earliest detectable abnormality in the developing neuroepithelium. Five isoforms of the human protein are produced by alternative splicing.

Protein type: Vesicle; Autophagy

Chromosomal Location of Human Ortholog: 11p11.2

Cellular Component: axoneme; cytoplasm; cytosol; mitochondrion; perinuclear region of cytoplasm

Molecular Function: protein binding; ubiquitin protein ligase binding

Biological Process: macroautophagy; positive regulation of phosphoinositide 3-kinase activity

Research Articles on AMBRA1

1. An increased expression of AMBRA1 and SQSTM1.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with AMBRA1 cdna clone

Products by Pathway	Pathway Diagram
Senescence And Autophagy Pathway antibodies	Senescence And Autophagy Pathway Diagram

Diseases associated with AMBRA1 cdna clone

Disease Name	Pubmed Publications
Neural Tube Defects Antibodies	>2 publications with AMBRA1 and Neural Tube Defects
Embryo Loss Antibodies	>1 publications with AMBRA1 and Embryo Loss
Nervous System Diseases Antibodies	>1 publications with AMBRA1 and Nervous System Diseases