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CSF2RA cDNA Clone – Colony Stimulating Factor 2 Receptor, Alpha, Low-Affinity (Granulocyte-Macrophage) (Human)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1267471

MBS1267471 is a cDNA clone targeting CSF2RA. More details

$235 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CSF2RA, cDNA Clone
Full Product Name
CSF2RA cDNA Clone
Product Gene Name
CSF2RA cdna clone
Sequence
atgcttctcc tggtgacaag ccttctgctc tgtgagttac cacacccagc attcctcctg atcccagaga aatcggatct gcgaacagtg gcaccagcct ctagtctcaa tgtgaggttt gactccagga cgatgaattt aagctgggac tgccaagaaa acacaacctt cagcaagtgt ttcttaactg acaagaagaa cagagtcgtg gaacccaggc tcagtaacaa cgaatgttcg tgcacatttc gtgaaatttg tctgcatgaa ggagtcacat ttgaggttca cgtgaatact agtcaaagag gatttcaaca gaaactgctt tatccaaatt caggaaggga gggtaccgct gctcagaatt tctcctgttt catctacaat gcggatttaa tgaactgtac ctgggcgagg ggtccgacgg ccccccgtga cgtccagtat tttttgtaca tacgaaactc aaagagaagg agggagatcc ggtgtcctta ttacatacaa gactcaggaa cccatgtggg atgtcacctg gataacctgt caggattaac gtctcgcaat tactttctgg ttaacggaac cagccgagaa attggcatcc aattctttga ttcacttttg gacacaaaga aaatagaacg attcaaccct cccagcaatg tcaccgtacg ttgcaacacg acgcactgcc tcgtacggtg gaaacagccc aggacctatc agaagctgtc gtacctggac tttcagtacc agctggacgt ccacagaaag aatacccagc ctggcacgga aaacctactg attaatgttt ctggtgattt ggaaaataga tacaactttc caagctctga gcccagagca aaacacagtg tgaagatcag agctgcagac gtccgcatct tgaattggag ctcctggagt gaagccattg aatttggttc tgacgacggg aacctcggct ctgtgtacat ttatgtgctc ctaatcgtgg gaacccttgt ctgtggcatc gtcctcggct tcctctttaa aaggttcctt aggatacagc ggctgttccc gccagttcca cagatcaaag acaaactgaa tgataaccat gaggtggaag acgagatcat ctgggaggaa ttcaccccag aggaagggaa aggctaccgc gaagaggtct tgaccgtgaa ggaaattacc tga
Molecular Weight
31,101 Da
OMIM
300770
Vector
pENTR223.1 or pUC
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of CSF2RA cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CSF2RA. It may not necessarily be applicable to this product.

NCBI GI #
12803600
NCBI GeneID
1438
NCBI Accession #
BC002635
UniProt Secondary Accession #
O00207; Q14429; Q14430; Q14431; Q16564; A7J003; A8KAM1; B4DW68; J3JS76; J3JS77
UniProt Related Accession #
P15509
NCBI Official Full Name
Homo sapiens colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage), mRNA
NCBI Official Synonym Full Names
colony stimulating factor 2 receptor alpha subunit
NCBI Official Symbol
CSF2RA
NCBI Official Synonym Symbols
GMR; CD116; CSF2R; SMDP4; CDw116; CSF2RX; CSF2RY; GMCSFR; CSF2RAX; CSF2RAY; GM-CSF-R-alpha
UniProt Protein Name
Granulocyte-macrophage colony-stimulating factor receptor subunit alpha
UniProt Synonym Protein Names
CDw116; CD_antigen: CD116
Protein Family
Granulocyte-macrophage colony-stimulating factor receptor
UniProt Gene Name
CSF2RA
UniProt Synonym Gene Names
CSF2R; CSF2RY; GM-CSF-R-alpha; GMCSFR-alpha; GMR-alpha
UniProt Entry Name
CSF2R_HUMAN
NCBI Protein Information
granulocyte-macrophage colony-stimulating factor receptor subunit alpha

NCBI Summary for CSF2RA

The protein encoded by this gene is the alpha subunit of the heterodimeric receptor for colony stimulating factor 2, a cytokine which controls the production, differentiation, and function of granulocytes and macrophages. The encoded protein is a member of the cytokine family of receptors. This gene is found in the pseudoautosomal region (PAR) of the X and Y chromosomes. Multiple transcript variants encoding different isoforms have been found for this gene, with some of the isoforms being membrane-bound and others being soluble. [provided by RefSeq, Jul 2008]
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UniProt Comments for CSF2RA

CSF2RA: Low affinity receptor for granulocyte-macrophage colony- stimulating factor. Transduces a signal that results in the proliferation, differentiation, and functional activation of hematopoietic cells. Defects in CSF2RA are the cause of pulmonary surfactant metabolism dysfunction type 4 (SMDP4). A rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress. Belongs to the type I cytokine receptor family. Type 5 subfamily. 8 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, cytokine; Membrane protein, integral

Chromosomal Location of Human Ortholog: Xp22.32 and Yp11.3

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: protein binding; protein-tyrosine kinase activity; Ras guanyl-nucleotide exchange factor activity; receptor activity

Biological Process: cellular protein metabolic process; MAPKKK cascade

Disease: Surfactant Metabolism Dysfunction, Pulmonary, 4
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Research Articles on CSF2RA

1. regulatory molecule causative of aortic dissection and intramural haematoma

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with CSF2RA cdna clone

 Products by Pathway  Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Interleukin Receptor SHC Signaling Pathway antibodies  Interleukin Receptor SHC Signaling Pathway Diagram
 Interleukin-2 Signaling Pathway antibodies  Interleukin-2 Signaling Pathway Diagram
 Interleukin-3, 5 And GM-CSF Signaling Pathway antibodies  Interleukin-3, 5 And GM-CSF Signaling Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram

Diseases associated with CSF2RA cdna clone

 Disease Name  Pubmed Publications
 Heart Diseases Antibodies  >2 publications with CSF2RA and Heart Diseases
 Neoplasms Antibodies  >2 publications with CSF2RA and Neoplasms
 Cardiovascular Diseases Antibodies  >2 publications with CSF2RA and Cardiovascular Diseases
 Skin Diseases Antibodies  >1 publications with CSF2RA and Skin Diseases
 Brain Diseases Antibodies  >1 publications with CSF2RA and Brain Diseases
 Nervous System Diseases Antibodies  >1 publications with CSF2RA and Nervous System Diseases
 Heart Defects, Congenital Antibodies  >1 publications with CSF2RA and Heart Defects, Congenital
 Necrosis Antibodies  >1 publications with CSF2RA and Necrosis
 Immune System Diseases Antibodies  >1 publications with CSF2RA and Immune System Diseases
 Prenatal Exposure Delayed Effects Antibodies  >1 publications with CSF2RA and Prenatal Exposure Delayed Effects

Organs/Tissues associated with CSF2RA cdna clone

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >9 publications with CSF2RA and Blood
 Lung Antibodies  >6 publications with CSF2RA and Lung
 Brain Antibodies  >3 publications with CSF2RA and Brain
 Kidney Antibodies  >1 publications with CSF2RA and Kidney
 Bone Marrow Antibodies  >1 publications with CSF2RA and Bone Marrow
 Liver Antibodies  >1 publications with CSF2RA and Liver
 Skin Antibodies  >1 publications with CSF2RA and Skin
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