Human DFNA5 cDNA Clone Expression Plasmid – Cat# MBS1273052

DFNA5 cDNA Clone – Deafness, Autosomal Dominant 5 (Human)

Name: DFNA5 cDNA Clone; Deafness, Autosomal Dominant 5; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1273052
Price: 235 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1273052

MBS1273052 is a cDNA clone targeting DFNA5. More details

$235 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

DFNA5, cDNA Clone

Full Product Name

DFNA5 cDNA Clone

Product Gene Name

DFNA5 cdna clone

Sequence

ATGTTTGCCA AAGCAACCAG GAATTTTCTT AGAGAAGTTG ATGCTGATGG TGACCTGATT GCAGTATCAA ATCTGAATGA CTCTGATAAG TTACAGCTTC TAAGTCTGGT GACAAAAAAG AAGAGATTCT GGTGCTGGCA GAGACCCAAG TACCAGTTTT TATCCCTCAC CCTTGGCGAT GTACTCATAG AAGACCAATT TCCGAGTCCA GTGGTCGTGG AGTCGGACTT TGTGAAATAC GAGGGCAAGT TTGCAAACCA CGTGAGTGGA ACCCTGGAGA CTGCACTGGG GAAGGTCAAG CTGAACCTGG GGGGCAGCAG CCGCGTAGAG AGCCAGTCTT CATTTGGAAC CCTGAGGAAG CAGGAGGTGG ATTTGCAGCA GCTCATCAGA GACTCTGCCG AGAGAACAAT AAATCTGAGA AACCCTGTGC TCCAGCAGGT GCTGGAAGGA AGGAATGAGG TCCTGTGCGT TTTGACACAG AAGATCACGA CGATGCAGAA GTGTGTGATC TCTGAGCACA TGCAGGTCGA GGAGAAGTGT GGTGGCATCG TGGGCATCCA GACCAAGACG GTGCAGGTGT CAGCGACGGA GGATGGGAAT GTCACCAAGG ACTCCAACGT GGTGCTGGAG ATCCCAGCTG CCACCACCAT TGCCTACGGT GTCATTGAGT TATACGTGAA ACTGGACGGC CAGTTCGAGT TCTGCCTTCT CCGAGGGAAG CAAGGTGGCT TCGAGAACAA GAAGAGAATT GACTCTGTCT ACCTGGACCC CCTGGTCTTT CGAGAGTTTG CATTCATAGA CATGCCAGAT GCTGCGCATG GGATATCTTC CCAGGATGGA CCATTAAGTG TTTTAAAGCA AGCGACCCTG CTCCTGGAGA GGAATTTCCA TCCATTTGCG GAGCTGCCTG AGCCACAACA GACAGCTTTG AGTGACATCT TCCAGGCGGT CCTATTTGAT GATGAACTAC TCATGGTCCT GGAACCAGTG TGCGATGACC TGGTCAGCGG CCTCTCGCCC ACAGTGGCGG TGCTGGGGGA GCTGAAGCCC CGGCAGCAGC AGGACCTTGT GGCCTTCCTG CAGCTGGTGG GGTGCAGCTT ACAGGGTGGG TGTCCGGGCC CCGAGGATGC AGGCAGCAAG CAGCTGTTTA TGACAGCCTA CTTCTTGGTC AGTGCCCTCG CAGAAATGCC AGATAGCGCA GCAGCTCTGC TGGGCACTTG CTGCAAACTC CAGATCATTC CCACACTGTG CCACTTGCTT CGTGCTCTGT CTGATGATGG AGTATCTGAT CTTGAAGACC CAACCTTGAC TCCCCTGAAA GATACAGAAA GGTTTGGGAT TGTGCAGCGC TTGTTTGCCT CAGCTGACAT TAGTCTGGAG AGACTGAAGT CATCTGTGAA AGCTGTCATT CTGAAGGACT CTAAAGTCTT CCCACTGCTT CTTTGTATAA CCCTGAATGG ACTCTGTGCT TTAGGCAGAG AACATTCATG A

Molecular Weight

36,043 Da

OMIM

600994

Vector

pENTR223.1

Clone Sequence Report

Provided with product shipment

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of DFNA5 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for DFNA5. It may not necessarily be applicable to this product.

NCBI GI #

115528709

NCBI GeneID

1687

NCBI Accession #

BC125065

UniProt Secondary Accession #

O14590; Q08AQ8; Q9UBV3; A4D156; B2RAX9; B3KT05

UniProt Related Accession #

O60443

NCBI Official Full Name

Homo sapiens deafness, autosomal dominant 5, mRNA

NCBI Official Synonym Full Names

DFNA5, deafness associated tumor suppressor

NCBI Official Symbol

DFNA5

NCBI Official Synonym Symbols

ICERE-1

UniProt Protein Name

Non-syndromic hearing impairment protein 5

UniProt Synonym Protein Names

Inversely correlated with estrogen receptor expression 1; ICERE-1

Protein Family

Non-syndromic hearing impairment protein

UniProt Gene Name

DFNA5

UniProt Synonym Gene Names

ICERE1; ICERE-1

UniProt Entry Name

DFNA5_HUMAN

NCBI Protein Information

non-syndromic hearing impairment protein 5

NCBI Summary for DFNA5

Hearing impairment is a heterogeneous condition with over 40 loci described. The protein encoded by this gene is expressed in fetal cochlea, however, its function is not known. Nonsyndromic hearing impairment is associated with a mutation in this gene. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

UniProt Comments for DFNA5

DFNA5: Involved in apoptosis and cell survival. Plays a role in the TP53-regulated cellular response to DNA damage probably by cooperating with TP53. Defects in DFNA5 are the cause of deafness autosomal dominant type 5 (DFNA5). DFNA5 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. Is a tumor suppressor gene with an important role in major types of tumors. Could be a valuable molecular marker in cancer. Belongs to the gasdermin family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Tumor suppressor

Chromosomal Location of Human Ortholog: 7p15

Cellular Component: cytoplasm

Biological Process: negative regulation of cell proliferation; sensory perception of sound

Disease: Deafness, Autosomal Dominant 5

Research Articles on DFNA5

1. Genetic variations in the EYA4, GRHL2 and DFNA5 genes and their interactions with occupational noise exposure may play an important role in the incidence of noise-induced hearing loss (NIHL).

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with DFNA5 cdna clone

Disease Name	Pubmed Publications
Hearing Loss Antibodies	>33 publications with DFNA5 and Hearing Loss
Nervous System Diseases Antibodies	>32 publications with DFNA5 and Nervous System Diseases
Neoplasms Antibodies	>10 publications with DFNA5 and Neoplasms
Breast Neoplasms Antibodies	>5 publications with DFNA5 and Breast Neoplasms
Deafness, Autosomal Dominant 5 Antibodies	>5 publications with DFNA5 and Deafness, Autosomal Dominant 5
Congenital Abnormalities Antibodies	>3 publications with DFNA5 and Congenital Abnormalities
Craniofacial Abnormalities Antibodies	>2 publications with DFNA5 and Craniofacial Abnormalities
Disease Models, Animal Antibodies	>2 publications with DFNA5 and Disease Models, Animal
Necrosis Antibodies	>1 publications with DFNA5 and Necrosis

Organs/Tissues associated with DFNA5 cdna clone

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>2 publications with DFNA5 and Brain
Bone Antibodies	>1 publications with DFNA5 and Bone
Muscle Antibodies	>1 publications with DFNA5 and Muscle
Skin Antibodies	>1 publications with DFNA5 and Skin
Uterus Antibodies	>1 publications with DFNA5 and Uterus
Prostate Antibodies	>1 publications with DFNA5 and Prostate
Kidney Antibodies	>1 publications with DFNA5 and Kidney
Placenta Antibodies	>1 publications with DFNA5 and Placenta