Human DPH1 cDNA Clone Expression Plasmid – Cat# MBS1274705

DPH1 cDNA Clone – DPH1 Homolog (S. Cerevisiae) (Human)

Name: DPH1 cDNA Clone; DPH1 Homolog (S. Cerevisiae); Human; MyBioSource
Brand: MyBioSource
SKU: MBS1274705
Price: 390 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1274705

MBS1274705 is a cDNA clone targeting DPH1. More details

$390 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

DPH1, cDNA Clone

Full Product Name

DPH1 cDNA Clone

Product Gene Name

DPH1 cdna clone

Sequence

ATGGACACCT CGGCCCAAGA CTTCCGGGTG CTGTACGTCT TTGTGGACAT CCGGATAGAC ACTATACACC TCCTGGACTC TCTCCGCCTC ACCTTTCCCC CAGCCACTGC CCTTGCCCTG GTCAGCACCA TTCAGTTTGT GTCGACCTTG CAGGCAGCCG CCCAGGAGCT GAAAGCCGAG TATCGTGTGA GTGTCCCACA GTGCAAGCCC CTGTCCCCTG GAGAGATCCT GGGCTGCACA TCCCCCCGAC TGTCCAAAGA GGTGGAGGCC GTTGTGTATC TTGGAGATGG CCGCTTCCAT CTGGAGTCTG TCATGATTGC CAACCCCAAT GTCCCCGCTT ACCGGTATGA CCCATATAGC AAAGTCCTAT CCAGAGAACA CTATGACCAC CAGCGCATGC AGGCTGCTCG CCAAGAAGCC ATAGCCACTG CCCGCTCAGC TAAGTCCTGG GGCCTTATTC TGGGCACTTT GGGCCGCCAG GGCAGTCCTA AGATCCTGGA GCACCTGGAA TCTCGACTCC GAGCCTTGGG CCTTTCCTTT GTGAGGCTGC TGCTCTCTGA GATCTTCCCC AGCAAGCTTA GCCTACTTCC CGAGGTGGAT GTGTGGGTGC AGGTGGCATG TCCACGTCTC TCCATTGACT GGGGCACAGC CTTCCCCAAG CCGCTGCTGA CACCCTATGA GGCGGCCGTG GCTCTGAGGG ACATTTCCTG GCAGCAGCCC TACCCGATGG ACTTCTACGC TGGCAGCTCC TTGGGGCCCT GGACGGTGAA CCACGGCCAG GACCGCCGTC CCCACGCCCC GGGCCGGCCC GCGCGGGGGA AGGTGCAGGA GGGGTCCGCG CGTCCCCCTT CGGCCGTGGC TTGCGAGGAC TGCAGCTGCA GGGACGAGAA GGTGGCGCCG CTGGCTCCTT GA

Molecular Weight

33,516 Da

OMIM

603527

Vector

Please Inquire

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of DPH1 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for DPH1. It may not necessarily be applicable to this product.

NCBI GI #

64654637

NCBI GeneID

1801

NCBI Accession #

BC096088

UniProt Secondary Accession #

Q16439; Q4VBA2; Q9BTW7; Q9UCY0; D3DTI3

UniProt Related Accession #

Q9BZG8

NCBI Official Full Name

Homo sapiens DPH1 homolog (S. cerevisiae), mRNA

NCBI Official Synonym Full Names

diphthamide biosynthesis 1

NCBI Official Symbol

DPH1

NCBI Official Synonym Symbols

DPH2L; OVCA1; DEDSSH; DPH2L1

UniProt Protein Name

Diphthamide biosynthesis protein 1

UniProt Synonym Protein Names

DPH1 homolog; HsDph1; Diphthamide biosynthesis protein 2 homolog-like 1; DPH-like 1; DPH2-like 1; Diphthamide biosynthesis protein 2-like; Ovarian cancer-associated gene 1 protein

Protein Family

Deubiquitination-protection protein

UniProt Gene Name

DPH1

UniProt Synonym Gene Names

DPH2L; DPH2L1; OVCA1; HsDph1; DPH-like 1; DPH2-like 1; Diphthamide biosynthesis protein 2-like

UniProt Entry Name

DPH1_HUMAN

NCBI Protein Information

diphthamide biosynthesis protein 1

NCBI Summary for DPH1

Diphthamide is a unique posttranslationally modified histidine found only in translation elongation factor-2 (EEF2; MIM 130610). This modification is conserved from archaebacteria to humans and serves as the target for ADP-ribosylation and inactivation of EEF2 by diphtheria toxin (DT) and Pseudomonas exotoxin A. DPH1 is 1 of several enzymes involved in synthesis of diphthamide in EEF2 (Liu et al., 2004 [PubMed 15485916]).[supplied by OMIM, Mar 2008]

UniProt Comments for DPH1

DPH1: Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2. When overexpressed, suppresses colony formation ability and growth rate of ovarian cancer cells. Acts also as a tumor suppressor in lung and breast cancers. Plays a role in embryonic growth, organogenesis and postnatal survival. Belongs to the DPH1/DPH2 family. DPH1 subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Tumor suppressor

Chromosomal Location of Human Ortholog: 17p13.3

Cellular Component: cytosol

Molecular Function: protein binding

Biological Process: peptidyl-diphthamide biosynthetic process from peptidyl-histidine

Disease: Developmental Delay With Short Stature, Dysmorphic Features, And Sparse Hair

Research Articles on DPH1

1. Results identified a second homozygous missense variant in DPH1, seen in four members of a founder population, and associated with autosomal recessive intellectual disability with short stature, craniofacial, and ectodermal anomalies.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with DPH1 cdna clone

Disease Name	Pubmed Publications
Drug Toxicity Antibodies	>2 publications with DPH1 and Drug Toxicity
Congenital Abnormalities Antibodies	>2 publications with DPH1 and Congenital Abnormalities
Abnormalities, Multiple Antibodies	>2 publications with DPH1 and Abnormalities, Multiple
Necrosis Antibodies	>2 publications with DPH1 and Necrosis
Atherosclerosis Antibodies	>1 publications with DPH1 and Atherosclerosis
Atrophy Antibodies	>1 publications with DPH1 and Atrophy
Heart Defects, Congenital Antibodies	>1 publications with DPH1 and Heart Defects, Congenital
Eye Abnormalities Antibodies	>1 publications with DPH1 and Eye Abnormalities

Organs/Tissues associated with DPH1 cdna clone

Organ/Tissue Name	Pubmed Publications
Ovary Antibodies	>3 publications with DPH1 and Ovary
Embryonic Tissue Antibodies	>2 publications with DPH1 and Embryonic Tissue
Heart Antibodies	>2 publications with DPH1 and Heart
Blood Antibodies	>2 publications with DPH1 and Blood
Lung Antibodies	>1 publications with DPH1 and Lung
Testis Antibodies	>1 publications with DPH1 and Testis
Placenta Antibodies	>1 publications with DPH1 and Placenta
Muscle Antibodies	>1 publications with DPH1 and Muscle
Eye Antibodies	>1 publications with DPH1 and Eye
Bone Antibodies	>1 publications with DPH1 and Bone