Human EPHX1 cDNA Clone Expression Plasmid – Cat# MBS1270716

EPHX1 cDNA Clone – Epoxide Hydrolase 1, Microsomal (Xenobiotic) (Human)

Name: EPHX1 cDNA Clone; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1270716
Price: 235 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1270716

MBS1270716 is a cDNA clone targeting EPHX1. More details

$235 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

EPHX1, cDNA Clone

Full Product Name

EPHX1 cDNA Clone

Product Gene Name

EPHX1 cdna clone

Sequence

atgtggctag aaatcctcct cacttcagtg ctgggctttg ccatctactg gttcatctcc cgggacaaag aggaaacttt gccacttgaa gatgggtggt gggggccagg cacgaggtcc gcagccaggg aggacgacag catccgccct ttcaaggtgg aaacgtcaga tgaggagatc cacgacttac accagaggat cgataagttc cgtttcaccc cacctttgga ggacagctgc ttccactatg gcttcaactc caactacctg aagaaagtca tctcctactg gcggaatgaa tttgactgga agaagcaggt ggagattctc aacagatacc ctcacttcaa gactaagatt gaagggctgg acatccactt catccacgtg aagccccccc agctgcccgc aggccatacc ccgaagccct tgctgatggt gcacggctgg cccggctctt tctacgagtt ttataagatc atcccactcc tgactgaccc caagaaccat ggcctgagcg atgagcacgt ttttgaagtc atctgccctt ccatccctgg ctatggcttc tcagaggcat cctccaagaa ggggttcaac tcggtggcca ccgccaggat cttttacaag ctgatgctgc ggctgggctt ccaggaattc tacattcaag gaggggactg ggggtccctg atctgcacta atatggccca gctggtgccc agccacgtga aaggcctgca cttgaacatg gctttggttt taagcaactt ctctaccctg accctcctcc tgggacagcg tttcgggagg tttcttggcc tcactgagag ggatgtggag ctgctgtacc ccgtcaagga gaaggtattc tacagcctga tgagggagag cggctacatg cacatccagt gcaccaagcc tgacaccgta ggctctgctc tgaatgactc tcctgtgggt ctggctgcct atattctaga gaagttttcc acctggacca atacggaatt ccgatacctg gaggatggag gcctggaaag gaagttctcc ctggacgacc tgctgaccaa cgtcatgctc tactggacaa caggcaccat catctcctcc cagcgcttct acaaggagaa cctgggacag ggctggatga cccagaagca tgagcggatg aaggtctatg tgcccactgg cttctctgcc ttcccttttg agctattgca cacgcctgaa aagtgggtga ggttcaagta cccaaagctc atctcctatt cctacatggt tcgtgggggc cactttgcgg cctttgagga gccggagctg ctcgcccagg acatccgcaa gttcctgtcg gtgctggagc ggcaatga

Molecular Weight

52,949 Da

OMIM

132810

Vector

pENTR223.1 or pUC

Clone Sequence Report

Provided with product shipment

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of EPHX1 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for EPHX1. It may not necessarily be applicable to this product.

NCBI GI #

13097728

NCBI GeneID

2052

NCBI Accession #

BC003567

UniProt Secondary Accession #

Q5VTJ6; Q9NP75; Q9NPE7; Q9NQU6; Q9NQU7; Q9NQU8; Q9NQU9; Q9NQV0; Q9NQV1; Q9NQV2; B2R8N0

UniProt Related Accession #

P07099

NCBI Official Full Name

Homo sapiens epoxide hydrolase 1, microsomal (xenobiotic), mRNA

NCBI Official Synonym Full Names

epoxide hydrolase 1

NCBI Official Symbol

EPHX1

NCBI Official Synonym Symbols

MEH; EPHX; EPOX; HYL1

UniProt Protein Name

Epoxide hydrolase 1

UniProt Synonym Protein Names

Epoxide hydratase; Microsomal epoxide hydrolase

UniProt Gene Name

EPHX1

UniProt Synonym Gene Names

EPHX; EPOX

UniProt Entry Name

HYEP_HUMAN

NCBI Protein Information

epoxide hydrolase 1

NCBI Summary for EPHX1

Epoxide hydrolase is a critical biotransformation enzyme that converts epoxides from the degradation of aromatic compounds to trans-dihydrodiols which can be conjugated and excreted from the body. Epoxide hydrolase functions in both the activation and detoxification of epoxides. Mutations in this gene cause preeclampsia, epoxide hydrolase deficiency or increased epoxide hydrolase activity. Alternatively spliced transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Dec 2008]

UniProt Comments for EPHX1

Ephx1: Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. In some populations, the high activity haplotype tyr113/his139 is overrepresented among women suffering from pregnancy-induced hypertension (pre-eclampsia) when compared with healthy controls. Defects in EPHX1 are a cause of familial hypercholanemia (FHCA). FHCA is a disorder characterized by elevated serum bile acid concentrations, itching, and fat malabsorption. Belongs to the peptidase S33 family.

Protein type: Membrane protein, integral; Hydrolase; EC 3.3.2.9; Xenobiotic Metabolism - metabolism by cytochrome P450

Chromosomal Location of Human Ortholog: 1q42.1

Cellular Component: endoplasmic reticulum membrane

Molecular Function: cis-stilbene-oxide hydrolase activity; epoxide hydrolase activity

Biological Process: xenobiotic metabolic process

Disease: Hypercholanemia, Familial; Preeclampsia/eclampsia 1

Research Articles on EPHX1

1. Null-GSTT1 and null-GSTM1 genotypes and Cytochrome P4502E1 (CYP2E1: rs2031920, rs3813867) may support the hematotoxicity of benzene-exposed workers in China, and we can make use of it to select susceptible population

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with EPHX1 cdna clone

Products by Pathway	Pathway Diagram
Aflatoxin B1 Metabolism Pathway antibodies	Aflatoxin B1 Metabolism Pathway Diagram
Benzo(a)pyrene Metabolism Pathway antibodies	Benzo(a)pyrene Metabolism Pathway Diagram
Bile Secretion Pathway antibodies	Bile Secretion Pathway Diagram
Bile Secretion Pathway antibodies	Bile Secretion Pathway Diagram
Chemical Carcinogenesis Pathway antibodies	Chemical Carcinogenesis Pathway Diagram
Chemical Carcinogenesis Pathway antibodies	Chemical Carcinogenesis Pathway Diagram
Metabolism Of Xenobiotics By Cytochrome P450 Pathway antibodies	Metabolism Of Xenobiotics By Cytochrome P450 Pathway Diagram
Metabolism Of Xenobiotics By Cytochrome P450 Pathway antibodies	Metabolism Of Xenobiotics By Cytochrome P450 Pathway Diagram
Metapathway Biotransformation antibodies	Metapathway Biotransformation Diagram

Diseases associated with EPHX1 cdna clone

Disease Name	Pubmed Publications
Neoplasms Antibodies	>351 publications with EPHX1 and Neoplasms
Drug Toxicity Antibodies	>217 publications with EPHX1 and Drug Toxicity
Cardiovascular Diseases Antibodies	>174 publications with EPHX1 and Cardiovascular Diseases
Inflammation Antibodies	>168 publications with EPHX1 and Inflammation
Liver Diseases Antibodies	>132 publications with EPHX1 and Liver Diseases
Carcinoma Antibodies	>109 publications with EPHX1 and Carcinoma
Liver Neoplasms Antibodies	>107 publications with EPHX1 and Liver Neoplasms
Neoplasms, Experimental Antibodies	>71 publications with EPHX1 and Neoplasms, Experimental
Lung Neoplasms Antibodies	>68 publications with EPHX1 and Lung Neoplasms
Adenocarcinoma Antibodies	>60 publications with EPHX1 and Adenocarcinoma

Organs/Tissues associated with EPHX1 cdna clone

Organ/Tissue Name	Pubmed Publications
Liver Antibodies	>1160 publications with EPHX1 and Liver
Blood Antibodies	>458 publications with EPHX1 and Blood
Lung Antibodies	>292 publications with EPHX1 and Lung
Kidney Antibodies	>169 publications with EPHX1 and Kidney
Brain Antibodies	>89 publications with EPHX1 and Brain
Heart Antibodies	>79 publications with EPHX1 and Heart
Muscle Antibodies	>77 publications with EPHX1 and Muscle
Intestine Antibodies	>73 publications with EPHX1 and Intestine
Skin Antibodies	>71 publications with EPHX1 and Skin
Testis Antibodies	>36 publications with EPHX1 and Testis