Human MCM2 cDNA Clone Expression Plasmid – Cat# MBS1272992

MCM2 cDNA Clone – Minichromosome Maintenance Complex Component 2 (Human)

Name: MCM2 cDNA Clone; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1272992
Price: 1000 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1272992

MBS1272992 is a cDNA clone targeting MCM2. More details

$1000 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

MCM2, cDNA Clone

Full Product Name

MCM2 cDNA Clone

Product Gene Name

MCM2 cdna clone

Sequence

atggcggaat catcggaatc cttcaccatg gcatccagcc cggcccagcg tcggcgaggc aatgatcctc tcacctccag ccctggccga agctcccggc gtactgatgc cctcacctcc agccctggcc gtgaccttcc accatttgag gatgagtccg aggggctcct aggcacagag gggcccctgg aggaagaaga ggatggagag gagctcattg gagatggcat ggaaagggac taccgcgcca tcccagagct ggacgcctat gaggccgagg gactggctct ggatgatgag gacgtagagg agctgacggc cagtcagagg gaggcagcag agcgggccat gcggcagcgt gaccgggagg ctggccgggg cctgggccgc atgcgccgtg ggctcctgta tgacagcgat gaggaggacg aggagcgccc tgcccgcaag cgccgccagg tggagcgggc cacggaggac ggcgaggagg acgaggagat gatcgagagc atcgagaacc tggaggatct caaaggccac tctgtgcgcg agtgggtgag catggcgggc ccccggctgg agatccacca ccgcttcaag aacttcctgc gcactcacgt cgacagccac ggccacaacg tcttcaagga gcgcatcagc gacatgtgca aagagaaccg tgagagcctg gtggtgaact atgaggactt ggcagccagg gagcacgtgc tggcctactt cctgcctgag gcaccggcgg agctgctgca gatctttgat gaggctgccc tggaggtggt actggccatg taccccaagt acgaccgcat caccaaccac atccatgtcc gcatctccca cctgcctctg gtggaggagc tgcgctcgct gaggcagctg catctgaacc agctgatccg caccagtggg gtggtgacca gctgcactgg cgtcctgccc cagctcagca tggtcaagta caactgcaac aagtgcaatt tcgtcctggg tcctttctgc cagtcccaga accaggaggt gaaaccaggc tcctgtcctg agtgccagtc ggccggcccc tttgaggtca acatggagga gaccatctat cagaactacc agcgtatccg aatccaggag agtccaggca aagtggcggc tggccggctg ccccgctcca aggacgccat tctcctcgca gatctggtgg acagctgcaa gccaggagac gagatagagc tgactggcat ctatcacaac aactatgatg gctccctcaa cactgccaat ggcttccctg tctttgccac tgtcatccta gccaaccacg tggccaagaa ggacaacaag gttgctgtag gggaactgac cgatgaagat gtgaagatga tcactagcct ctccaaggat cagcagatcg gagagaagat ctttgccagc attgctcctt ccatctatgg tcatgaagac atcaagagag gcctggctct ggccctgttc ggaggggagc ccaaaaaccc aggtggcaag cacaaggtac gtggtgatat caacgtgctc ttgtgcggag accctggcac agcgaagtcg cagtttctca agtatattga gaaagtgtcc agccgagcca tcttcaccac tggccagggg gcgtcggctg tgggcctcac ggcgtatgtc cagcggcacc ctgtcagcag ggagtggacc ttggaggctg gggccctggt tctggctgac cgaggagtgt gtctcattga tgaatttgac aagatgaatg accaggacag aaccagcatc catgaggcca tggagcaaca gagcatctcc atctcgaagg ctggcatcgt cacctccctg caggctcgct gcacggtcat tgctgccgcc aaccccatag gagggcgcta cgacccctcg ctgactttct ctgagaacgt ggacctcaca gagcccatca tctcacgctt tgacatcctg tgtgtggtga gggacaccgt ggacccagtc caggacgaga tgctggcccg cttcgtggtg ggcagccacg tcagacacca ccccagcaac aaggaggagg aggggctggc caatggcagc gctgctgagc ccgccatgcc caacacgtat ggcgtggagc ccctgcccca ggaggtcctg aagaagtaca tcatctacgc caaggagagg gtccacccga agctcaacca gatggaccag gacaaggtgg ccaagatgta cagtgacctg aggaaagaat ctatggcgac aggcagcatc cccattacgg tgcggcacat cgagtccatg atccgcatgg cggaggccca cgcgcgcatc catctgcggg actatgtgat cgaagacgac gtcaacatgg ccatccgcgt gatgctggag agcttcatag acacacagaa gttcagcgtc atgcgcagca tgcgcaagac ttttgcccgc tacctttcat tccggcgtga caacaatgag ctgttgctct tcatactgaa gcagttagtg gcagagcagg tgacatatca gcgcaaccgc tttggggccc agcaggacac tattgaggtc cctgagaagg acttggtgga taaggctcgt cagatcaaca tccacaacct ctctgcattt tatgacagtg agctcttcag gatgaacaag ttcagccacg acctgaaaag gaaaatgatc ctgcagcagt tctga

Molecular Weight

101,896 Da

OMIM

116945

Vector

Please Inquire

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of MCM2 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for MCM2. It may not necessarily be applicable to this product.

NCBI GI #

39645237

NCBI GeneID

4171

NCBI Accession #

BC007938

UniProt Secondary Accession #

Q14577; Q15023; Q8N2V1; Q969W7; Q96AE1; Q9BRM7

UniProt Related Accession #

P49736

NCBI Official Full Name

Homo sapiens minichromosome maintenance complex component 2, mRNA

NCBI Official Synonym Full Names

minichromosome maintenance complex component 2

NCBI Official Symbol

MCM2

NCBI Official Synonym Symbols

BM28; CCNL1; CDCL1; cdc19; DFNA70; D3S3194; MITOTIN

UniProt Protein Name

DNA replication licensing factor MCM2

UniProt Synonym Protein Names

Minichromosome maintenance protein 2 homolog; Nuclear protein BM28

Protein Family

DNA replication licensing factor

UniProt Gene Name

MCM2

UniProt Synonym Gene Names

BM28; CCNL1; CDCL1; KIAA0030

UniProt Entry Name

MCM2_HUMAN

NCBI Protein Information

DNA replication licensing factor MCM2

NCBI Summary for MCM2

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein forms a complex with MCM4, 6, and 7, and has been shown to regulate the helicase activity of the complex. This protein is phosphorylated, and thus regulated by, protein kinases CDC2 and CDC7. Multiple alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been defined. [provided by RefSeq, Oct 2012]

UniProt Comments for MCM2

MCM2: a mini-chromosome maintenance protein, essential for the initiation of eukaryotic genome replication. Allows DNA to undergo a single round of replication per cell cycle. Required for the entry in S phase and for cell division.

Protein type: EC 3.6.4.12; DNA-binding

Chromosomal Location of Human Ortholog: 3q21

Cellular Component: chromatin; cytoplasm; MCM complex; microtubule cytoskeleton; nuclear chromosome, telomeric region; nucleoplasm; nucleus

Molecular Function: DNA binding; protein binding

Biological Process: cell cycle; DNA replication; DNA replication initiation; G1/S transition of mitotic cell cycle

Disease: Deafness, Autosomal Dominant 70

Research Articles on MCM2

1. MCM2 expression is higher in ovarian and endometrial high-grade serous carcinomas (HGSC) than in ovarian or endometrial endometrioid carcinoma. Knockdown in ovarian HGSC cell line decreased cell proliferation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with MCM2 cdna clone

Products by Pathway	Pathway Diagram
Activation Of ATR In Response To Replication Stress Pathway antibodies	Activation Of ATR In Response To Replication Stress Pathway Diagram
Activation Of The Pre-replicative Complex Pathway antibodies	Activation Of The Pre-replicative Complex Pathway Diagram
Assembly Of The Pre-replicative Complex Pathway antibodies	Assembly Of The Pre-replicative Complex Pathway Diagram
Cell Cycle Pathway antibodies	Cell Cycle Pathway Diagram
Cell Cycle Checkpoints Pathway antibodies	Cell Cycle Checkpoints Pathway Diagram
Cell Cycle, Mitotic Pathway antibodies	Cell Cycle, Mitotic Pathway Diagram
Cell Cycle Pathway antibodies	Cell Cycle Pathway Diagram
Cell Cycle Pathway antibodies	Cell Cycle Pathway Diagram
Cell Cycle Pathway antibodies	Cell Cycle Pathway Diagram
DNA Replication Pathway antibodies	DNA Replication Pathway Diagram

Diseases associated with MCM2 cdna clone

Disease Name	Pubmed Publications
Neoplasms Antibodies	>225 publications with MCM2 and Neoplasms
Carcinoma Antibodies	>132 publications with MCM2 and Carcinoma
Adenocarcinoma Antibodies	>55 publications with MCM2 and Adenocarcinoma
Uterine Cervical Neoplasms Antibodies	>29 publications with MCM2 and Uterine Cervical Neoplasms
Precancerous Conditions Antibodies	>23 publications with MCM2 and Precancerous Conditions
Nervous System Diseases Antibodies	>19 publications with MCM2 and Nervous System Diseases
Breast Neoplasms Antibodies	>18 publications with MCM2 and Breast Neoplasms
Cell Transformation, Neoplastic Antibodies	>17 publications with MCM2 and Cell Transformation, Neoplastic
Brain Diseases Antibodies	>15 publications with MCM2 and Brain Diseases
Neoplasms, Experimental Antibodies	>14 publications with MCM2 and Neoplasms, Experimental

Organs/Tissues associated with MCM2 cdna clone

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>26 publications with MCM2 and Brain
Blood Antibodies	>24 publications with MCM2 and Blood
Lymph Node Antibodies	>22 publications with MCM2 and Lymph Node
Lymph Antibodies	>22 publications with MCM2 and Lymph
Lung Antibodies	>20 publications with MCM2 and Lung
Liver Antibodies	>16 publications with MCM2 and Liver
Cervix Antibodies	>14 publications with MCM2 and Cervix
Bone Antibodies	>14 publications with MCM2 and Bone
Prostate Antibodies	>12 publications with MCM2 and Prostate
Mouth Antibodies	>10 publications with MCM2 and Mouth