Human PC cDNA Clone Expression Plasmid – Cat# MBS1275662

PC cDNA Clone – Pyruvate Carboxylase (Human)

Name: PC cDNA Clone; Pyruvate Carboxylase; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1275662
Price: 1465 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1275662

MBS1275662 is a cDNA clone targeting PC. More details

$1465 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

PC, cDNA Clone

Full Product Name

PC cDNA Clone

Product Gene Name

PC cdna clone

Sequence

atgctgaagt tccgaacagt ccatgggggc ctgaggctcc tgggaatccg ccgaacctcc accgcccccg ctgcctcccc aaatgtccgg cgcctggagt ataagcccat caagaaagtc atggtggcca acagaggtga gattgccatc cgtgtgttcc gggcctgcac ggagctgggc atccgcaccg tagccatcta ctctgagcag gacacgggcc agatgcaccg gcagaaagca gatgaagcct atctcatcgg ccgcggcctg gcccccgtgc aggcctacct gcacatccca gacatcatca aggtggccaa ggagaacaac gtagatgcag tgcaccctgg ctacgggttc ctctctgagc gagcggactt cgcccaggcc tgccaggatg caggggtccg gtttattggg ccaagcccag aagtggtccg caagatggga gacaaggtgg aggcccgggc catcgccatt gctgcgggtg ttcccgttgt ccctggcaca gatgccccca tcacgtccct gcatgaggcc cacgagttct ccaacaccta cggcttcccc atcatcttca aggcggccta tgggggtgga gggcgtggca tgagggtggt gcacagctac gaggagctgg aggagaatta cacccgggcc tactcagagg ctctggccgc ctttgggaat ggggcgctgt ttgtggagaa gttcatcgag aagccacggc acatcgaggt gcagatcttg ggggaccagt atgggaacat cctgcacctg tacgagcgag actgctccat ccagcggcgg caccagaagg tggtcgagat tgcccccgcc gcccacctgg acccgcagct tcggactcgg ctcaccagcg actctgtgaa actcgctaaa caggtgggct acgagaacgc aggcaccgtg gagttcctgg tggacaggca cggcaagcac tacttcatcg aggtcaactc ccgcctgcag gtggagcaca cggtcacaga ggagatcacc gacgtagacc tggtccatgc tcagatccac gtggctgagg gcaggagcct acccgacctg ggcctgcggc aggagaacat ccgcatcaac gggtgtgcca tccagtgccg ggtcaccacc gaggaccccg cgcgcagctt ccagccggac accggccgca ttgaggtgtt ccggagcgga gagggcatgg gcatccgcct ggataatgct tccgccttcc aaggagccgt catctcgccc cactacgact ccctgctggt caaagtcatt gcccacggca aagaccaccc cacggccgcc accaagatga gcagggccct tgcggagttc cgcgtccgag gtgtgaagac caacatcgcc ttcctgcaga atgtgctcaa caaccagcag ttcctggcag gcactgtgga cacccagttc atcgacgaga acccagagct gttccagctg cggcctgcac agaaccgggc ccaaaagctg ttgcactacc tcggccatgt catggtaaac ggtccaacca ccccgattcc cgtcaaggcc agccccagcc ccacggaccc cgttgtccct gcagtgccca taggcccgcc cccggctggt ttcagagaca tcctgctgcg agaggggcct gagggctttg ctcgagctgt gcggaaccac ccggggctgc tgctgatgga cacgaccttc agggacgccc accagtcact gctggccact cgtgtgcgca cccacgatct caaaaagatc gccccctatg ttgcccacaa cttcagcaag ctcttcagca tggagaactg gggaggagcc acgtttgacg tcgccatgcg cttcctgtat gagtgcccct ggcggcggct gcaggagctc cgggagctca tccccaacat ccctttccag atgctgctgc ggggggccaa tgctgtgggc tacaccaact acccagacaa cgtggtcttc aagttctgtg aagtggccaa agagaatggc atggatgtct tccgtgtgtt tgactccctc aactacttgc ccaacatgct gctgggcatg gaggcggcag gaagtgccgg aggcgtggtg gaggctgcca tctcatacac gggcgacgtg gccgacccca gccgcaccaa gtactcactg cagtactaca tgggcttggc cgaagagctg gtgcgagctg gcacccacat cctgtgcatc aaggacatgg ccgggctgct gaagcccacg gcctgcacca tgctggtcag ctccctccgg gaccgcttcc ccgacctccc actgcacatc cacacccacg acacgtcagg ggcaggcgtg gcagccatgc tggcctgtgc ccaggctgga gctgatgtgg tggatgtggc agctgattcc atgtctggga tgacttcaca gcccagcatg ggggccctgg tggcctgtac cagagggact cccctggaca cagaggtgcc catggagcgc gtgtttgact acagtgagta ctgggagggg gctcggggac tgtacgcggc cttcgactgc acggccacca tgaagtctgg caactcggac gtgtatgaaa atgagatccc agggggccag tacaccaacc tgcacttcca ggcccacagc atggggcttg gctccaagtt caaggaggtc aagaaggcct atgtggaggc caaccagatg ctgggcgatc tcatcaaggt gacgccctcc tccaagatcg tgggggacct ggcccagttt atggtgcaga atggattgag ccgggcagag gccgaagctc aggcggaaga gctgtccttt ccccgctccg tggtggagtt cctgcagggc tacatcggtg tcccccatgg ggggttcccc gaaccctttc gctctaaggt actgaaggac ctgccaaggg tggaggggcg gcctggagcc tccctccctc ccctggatct gcaggcactg gagaaggagc tggtagaccg gcatggggag gaggtgacgc cggaagatgt gctctcagca gctatgtacc ccgatgtgtt tgcccacttc aaggacttca ctgccacctt tggccccctg gatagcctga atactcgcct cttcctgcag ggacccaaga tcgcagagga gtttgaggtg gagctggagc ggggcaagac gctgcacatc aaagccctgg ccgtgagcga cctgaaccgg gccggccaga ggcaggtctt ctttgagctc aatgggcagc tgcggtccat cttggtcaag gacacccagg ccatgaagga gatgcacttc caccccaagg ccctaaagga cgtgaagggc cagatcgggg cgcccatgcc tgggaaggtg atagacatca aagtggtggc aggggccaag gtggccaagg gccagcccct gtgtgtgctc agtgccatga agatggagac tgtggtgacc tcacccatgg agggtactgt ccgcaaggtt catgtgacca aggacatgac actggaaggt gacgacctca tcctggagat cgagtga

Molecular Weight

57,925 Da

OMIM

266150

Vector

Please Inquire

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of PC cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for PC. It may not necessarily be applicable to this product.

NCBI GI #

33871110

NCBI GeneID

5091

NCBI Accession #

BC011617

UniProt Secondary Accession #

Q16705; B4DN00

UniProt Related Accession #

P11498

NCBI Official Full Name

Homo sapiens pyruvate carboxylase, mRNA

NCBI Official Synonym Full Names

pyruvate carboxylase

NCBI Official Symbol

NCBI Official Synonym Symbols

PCB

UniProt Protein Name

Pyruvate carboxylase, mitochondrial

UniProt Synonym Protein Names

Pyruvic carboxylase; PCB

Protein Family

PC-esterase domain-containing protein

UniProt Gene Name

UniProt Synonym Gene Names

PCB

UniProt Entry Name

PYC_HUMAN

NCBI Protein Information

pyruvate carboxylase, mitochondrial

NCBI Summary for PC

This gene encodes pyruvate carboxylase, which requires biotin and ATP to catalyse the carboxylation of pyruvate to oxaloacetate. The active enzyme is a homotetramer arranged in a tetrahedron which is located exclusively in the mitochondrial matrix. Pyruvate carboxylase is involved in gluconeogenesis, lipogenesis, insulin secretion and synthesis of the neurotransmitter glutamate. Mutations in this gene have been associated with pyruvate carboxylase deficiency. Alternatively spliced transcript variants with different 5' UTRs, but encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008]

UniProt Comments for PC

PC: Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate. Defects in PC are the cause of pyruvate carboxylase deficiency (PC deficiency). PC deficiency leads to lactic acidosis, mental retardation and death. It occurs in three forms: mild or type A, severe neonatal or type B, and a very mild lacticacidemia.

Protein type: Carbohydrate Metabolism - citrate (TCA) cycle; EC 6.4.1.1; Carbohydrate Metabolism - pyruvate; Ligase; Mitochondrial

Chromosomal Location of Human Ortholog: 11q13.4-q13.5

Cellular Component: cytoplasm; cytosol; mitochondrial matrix; mitochondrion

Molecular Function: protein binding; pyruvate carboxylase activity

Biological Process: biotin metabolic process; gluconeogenesis; viral RNA genome packaging

Disease: Pyruvate Carboxylase Deficiency

Research Articles on PC

1. PC and PDH may be an important part of cellular adaptation to the IDH1 mutation and may serve as potential therapeutic targets

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with PC cdna clone

Products by Pathway	Pathway Diagram
Alanine And Aspartate Metabolism Pathway antibodies	Alanine And Aspartate Metabolism Pathway Diagram
Biosynthesis Of Amino Acids Pathway antibodies	Biosynthesis Of Amino Acids Pathway Diagram
Biosynthesis Of Amino Acids Pathway antibodies	Biosynthesis Of Amino Acids Pathway Diagram
Citrate Cycle (TCA Cycle) Pathway antibodies	Citrate Cycle (TCA Cycle) Pathway Diagram
Citrate Cycle (TCA Cycle) Pathway antibodies	Citrate Cycle (TCA Cycle) Pathway Diagram
Fatty Acid Biosynthesis Pathway antibodies	Fatty Acid Biosynthesis Pathway Diagram
Gluconeogenesis Pathway antibodies	Gluconeogenesis Pathway Diagram
Glucose Metabolism Pathway antibodies	Glucose Metabolism Pathway Diagram
Glycolysis And Gluconeogenesis Pathway antibodies	Glycolysis And Gluconeogenesis Pathway Diagram
Metabolism Pathway antibodies	Metabolism Pathway Diagram

Diseases associated with PC cdna clone

Disease Name	Pubmed Publications
Cardiovascular Diseases Antibodies	>174966 publications with PC and Cardiovascular Diseases
Neoplasms Antibodies	>122832 publications with PC and Neoplasms
Heart Diseases Antibodies	>82530 publications with PC and Heart Diseases
Liver Diseases Antibodies	>34875 publications with PC and Liver Diseases
Diabetes Mellitus Antibodies	>33910 publications with PC and Diabetes Mellitus
Inflammation Antibodies	>32481 publications with PC and Inflammation
Hypertension Antibodies	>30630 publications with PC and Hypertension
Kidney Diseases Antibodies	>24141 publications with PC and Kidney Diseases
Drug Toxicity Antibodies	>22332 publications with PC and Drug Toxicity
Hepatitis Antibodies	>21966 publications with PC and Hepatitis

Organs/Tissues associated with PC cdna clone

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>192254 publications with PC and Blood
Bone Antibodies	>42722 publications with PC and Bone
Brain Antibodies	>34484 publications with PC and Brain
Lung Antibodies	>33590 publications with PC and Lung
Liver Antibodies	>33141 publications with PC and Liver
Kidney Antibodies	>30532 publications with PC and Kidney
Skin Antibodies	>29469 publications with PC and Skin
Eye Antibodies	>17059 publications with PC and Eye
Intestine Antibodies	>14318 publications with PC and Intestine
Nerve Antibodies	>13604 publications with PC and Nerve