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PGD cDNA Clone – Phosphogluconate Dehydrogenase (Human)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1270924

MBS1270924 is a cDNA clone targeting PGD. More details

$235 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
PGD, cDNA Clone
Full Product Name
PGD cDNA Clone
Product Gene Name
PGD cdna clone
Sequence
atggcccaag ctgacatcgc gctgatcgga ttggccgtca tgggccagaa cttaattctg aacatgaatg accacggctt tgtggtctgt gcttttaata ggactgtctc caaagttgat gatttcttgg ccaatgaggc aaagggaacc aaagtggtgg gtgcccagtc cctgaaagag atggtctcca agctgaagaa gccccggcgg atcatcctcc tggtgaaggc tgggcaagct gtggatgatt tcatcgagaa attggtacca ttgttggata ctggtgacat catcattgac ggaggaaatt ctgaatatag ggacaccaca agacggtgcc gagacctcaa ggccaaggga attttatttg tggggagcgg agtcagtggt ggagaggaag gggcccggta tggcccatcg ctcatgccag gagggaacaa agaagcgtgg ccccacatca agaccatctt ccaaggcatt gctgcaaaag tgggaactgg agaaccctgc tgtgactggg tgggagatga gggagcaggc cacttcgtga agatggtgca caacgggata gagtatgggg acatgcagct gatctgtgag gcataccacc tgatgaaaga cgtgctgggc atggcgcagg acgagatggc ccaggccttt gaggattgga ataagacaga gctagactca ttcctgattg aaatcacagc caatattctc aagttccaag acaccgatgg caaacacctg ctgccaaaga tcagggacag cgcggggcag aagggcacag ggaagtggac cgccatctcc gccctggaat acggcgtacc cgtcaccctc attggagaag ctgtctttgc tcggtgctta tcatctctga aggatgagag aattcaagct agcaaaaagc tgaagggtcc ccagaagttc cagtttgatg gtgataagaa atcattcctg gaggacattc ggaaggcact ctacgcttcc aagatcatct cttacgctca aggctttatg ctgctaaggc aggcagccac cgagtttggc tggactctca attatggtgg catcgccctg atgtggagag ggggctgcat cattagaagt gtattcctag gaaagataaa ggatgcattt gatcgaaacc cggaacttca gaacctccta ctggacgact tctttaagtc agctgttgaa aactgccagg actcctggcg gcgggcagtc agcactgggg tccaggctgg cattcccatg ccctgtttta ccactgccct ctccttctat gacgggtaca gacatgagat gcttccagcc agcctcatcc aggctcagcg ggattacttc ggggctcaca cctatgaact cttggccaaa ccagggcagt ttatccacac caactggaca ggccatggtg gcaccgtgtc atcctcgtca tacaatgcct ga
Molecular Weight
51,872 Da
OMIM
172200
Vector
pENTR223.1 or pUC
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of PGD cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for PGD. It may not necessarily be applicable to this product.

NCBI GI #
38197131
NCBI GeneID
5226
NCBI Accession #
BC000368
UniProt Secondary Accession #
Q9BWD8; A8K2Y9; B4DQJ8
UniProt Related Accession #
P52209
NCBI Official Full Name
Homo sapiens phosphogluconate dehydrogenase, mRNA
NCBI Official Synonym Full Names
phosphogluconate dehydrogenase
NCBI Official Symbol
PGD
NCBI Official Synonym Symbols
6PGD
UniProt Protein Name
6-phosphogluconate dehydrogenase, decarboxylating
Protein Family
Prostaglandin D2 receptor
UniProt Gene Name
PGD
UniProt Synonym Gene Names
PGDH
UniProt Entry Name
6PGD_HUMAN
NCBI Protein Information
6-phosphogluconate dehydrogenase, decarboxylating

NCBI Summary for PGD

6-phosphogluconate dehydrogenase is the second dehydrogenase in the pentose phosphate shunt. Deficiency of this enzyme is generally asymptomatic, and the inheritance of this disorder is autosomal dominant. Hemolysis results from combined deficiency of 6-phosphogluconate dehydrogenase and 6-phosphogluconolactonase suggesting a synergism of the two enzymopathies. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2015]
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UniProt Comments for PGD

PGD: an oxidative carboxylase that catalyses the decarboxylating reduction of 6-phosphogluconate into ribulose 5-phosphate in the presence of NADP. This reaction is a component of the hexose mono-phosphate shunt and pentose phosphate pathways.

Protein type: Other Amino Acids Metabolism - glutathione; Oxidoreductase; Carbohydrate Metabolism - pentose phosphate pathway; EC 1.1.1.44

Chromosomal Location of Human Ortholog: 1p36.22

Cellular Component: cytosol; nucleus

Molecular Function: phosphogluconate dehydrogenase (decarboxylating) activity

Biological Process: pentose-phosphate shunt; pentose-phosphate shunt, oxidative branch
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Research Articles on PGD

1. Studies indicate link between the 6-phosphogluconate dehydrogenase, oxidative pentose phosphate pathway (PPP) and lipogenesis through Ru-5-P-dependent inhibition of serine/threonine protein kinase LKB1-AMPK signalling.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with PGD cdna clone

 Products by Pathway  Pathway Diagram
 Glutathione Metabolism Pathway antibodies  Glutathione Metabolism Pathway Diagram
 Glutathione Metabolism Pathway antibodies  Glutathione Metabolism Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Carbohydrates Pathway antibodies  Metabolism Of Carbohydrates Pathway Diagram
 Pentose Phosphate Pathway antibodies  Pentose Phosphate Pathway Diagram
 Pentose Phosphate Pathway antibodies  Pentose Phosphate Pathway Diagram
 Pentose Phosphate Pathway antibodies  Pentose Phosphate Pathway Diagram
 Pentose Phosphate Pathway (Pentose Phosphate Cycle) antibodies  Pentose Phosphate Pathway (Pentose Phosphate Cycle) Diagram
 Pentose Phosphate Pathway (Pentose Phosphate Cycle) antibodies  Pentose Phosphate Pathway (Pentose Phosphate Cycle) Diagram
 Pentose Phosphate Pathway (hexose Monophosphate Shunt) antibodies  Pentose Phosphate Pathway (hexose Monophosphate Shunt) Diagram

Diseases associated with PGD cdna clone

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >231 publications with PGD and Nervous System Diseases
 Inflammation Antibodies  >216 publications with PGD and Inflammation
 Neoplasms Antibodies  >155 publications with PGD and Neoplasms
 Brain Diseases Antibodies  >105 publications with PGD and Brain Diseases
 Anemia Antibodies  >93 publications with PGD and Anemia
 Muscular Diseases Antibodies  >43 publications with PGD and Muscular Diseases
 Necrosis Antibodies  >43 publications with PGD and Necrosis
 Kidney Diseases Antibodies  >40 publications with PGD and Kidney Diseases
 Drug Toxicity Antibodies  >33 publications with PGD and Drug Toxicity
 Breast Neoplasms Antibodies  >29 publications with PGD and Breast Neoplasms

Organs/Tissues associated with PGD cdna clone

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >688 publications with PGD and Blood
 Lung Antibodies  >201 publications with PGD and Lung
 Brain Antibodies  >160 publications with PGD and Brain
 Vascular Antibodies  >106 publications with PGD and Vascular
 Heart Antibodies  >104 publications with PGD and Heart
 Bone Antibodies  >94 publications with PGD and Bone
 Muscle Antibodies  >87 publications with PGD and Muscle
 Uterus Antibodies  >72 publications with PGD and Uterus
 Bone Marrow Antibodies  >70 publications with PGD and Bone Marrow
 Skin Antibodies  >68 publications with PGD and Skin
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