Human PML cDNA Clone Expression Plasmid – Cat# MBS1275482

PML cDNA Clone – Promyelocytic Leukemia (Human)

Name: PML cDNA Clone; Promyelocytic Leukemia; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1275482
Price: 880 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1275482

MBS1275482 is a cDNA clone targeting PML. More details

$880 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

PML, cDNA Clone

Full Product Name

PML cDNA Clone

Product Gene Name

PML cdna clone

Sequence

atggagcctg cacccgcccg atctccgagg ccccagcagg accccgcccg gccccaggag cccaccatgc ctccccccga gaccccctct gaaggccgcc agcccagccc cagccccagc cctacagagc gagcccccgc ttcggaggag gagttccagt ttctgcgctg ccagcaatgc caggcggaag ccaagtgccc gaagctgctg ccttgtctgc acacgctgtg ctcaggatgc ctggaggcgt cgggcatgca gtgccccatc tgccaggcgc cctggcccct aggtgcagac acacccgccc tggataacgt ctttttcgag agtctgcagc ggcgcctgtc ggtgtaccgg cagattgtgg atgcgcaggc tgtgtgcacc cgctgcaaag agtcggccga cttctggtgc tttgagtgcg agcagctcct ctgcgccaag tgcttcgagg cacaccagtg gttcctcaag cacgaggccc ggcccctagc agagctgcgc aaccagtcgg tgcgtgagtt cctggacggc acccgcaaga ccaacaacat cttctgctcc aaccccaacc accgcacccc tacgctgacc agcatctact gccgaggatg ttccaagccg ctgtgctgct cgtgcgcgct ccttgacagc agccacagtg atctcaagtg cgacatcagc gcagagatcc agcagcgaca ggaggagctg gacgccatga cgcaggcgct gcaggagcag gatagtgcct ttggcgcggt tcacgcgcag atgcacgcgg ctgtcggcca gctgggccgc gcgcgtgccg agaccgagga gctgatccgc gagcgcgtgc gccaggtggt agctcacgtg cgggctcagg agcgcgagct gctggaggct gtggacgcgc ggtaccagcg cgactacgag gagatggcca gtcggctggg ccgcctggat gctgtgctgc agcgcatccg cacgggcagc gcgctggtgc agaggatgaa gtgctacgcc tcggaccagg aggtgctgga catgcacggt ttcctgcgcc aggcgctctg ccgcctgcgc caggaggagc cccagagcct gcaagctgcc gtgcgcaccg atggcttcga cgagttcaag gtgcgcctgc aggacctcag ctcttgcatc acccagggga aagatgcagc tgtatccaag aaagccagcc cagaggctgc cagcactccc agggacccta ttgacgttga cctggatgtc tccaatacaa cgacagccca gaagaggaag tgcagccaga cccagtgccc caggaaggtc atcaagatgg agtctgagga ggggaaggag gcaaggttgg ctcggagctc cccggagcag cccaggccca gcacctccaa ggcagtctca ccaccccacc tggatggacc gcctagcccc aggagccccg tcataggaag tgaggtcttc ctgcccaaca gcaaccacgt ggccagtggc gccggggagg cagaggaacg cgttgtggtg atcagcagct cggaagactc agatgccgaa aactcgtgca tggagcccat ggagaccgcc gagccacagt cctcgccagc ccactcctcg ccagcccact cctcgccagc ccactcctcg ccagtccagt ctctgctgag agcacaagga gcctccagcc tgccctgtgg cacataccac cccccagctt ggcctcccca ccagcccgct gagcaggctg ccacccccga tgctgagcct cacagcgagc ctcctgatca ccaggagcgc cctgccgtcc accgtgggat ccgctacctg ttgtacagag cacagagagc catccgcctt cgccatgccc tccgcttgca ccctcaattg catcgggccc ctattcggac ttggtctccc catgtggtcc aagccagcac tcctgccatc acagggcccc tcaaccatcc tgccaatgcc caggaacatc ctgcccagct gcaaaggggc atcagcccac cccaccggat acgaggggct gtgcgatccc gcagccgctc cctccggggc tcctcccatt tatcccagtg gctcaacaac ttttttgccc tccccttctc ctccatggct tcccagcttg acatgtcttc cgtggtgggg gcaggggaag gcagagccca gactcttgga gcagttgttc cccctgggga ctctgtcaga ggctccatgg aggcctctca agtccaagtg cctctggaag cctctccaat tacattccca ccaccctgtg ccccagaaag gccccccatc agcccagtcc caggcgcccg tcaagcaggc ctctga

Molecular Weight

47,575 Da

OMIM

102578

Vector

Please Inquire

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of PML cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for PML. It may not necessarily be applicable to this product.

NCBI GI #

33875196

NCBI GeneID

5371

NCBI Accession #

BC000080

UniProt Secondary Accession #

P29591; P29592; P29593; Q00755; Q15959; Q59FP9; Q8WUA0; Q96S41; Q9BPW2; Q9BWP7; E9PBR7

UniProt Related Accession #

P29590

NCBI Official Full Name

Homo sapiens promyelocytic leukemia, mRNA

NCBI Official Synonym Full Names

promyelocytic leukemia

NCBI Official Symbol

PML

NCBI Official Synonym Symbols

MYL; RNF71; PP8675; TRIM19

UniProt Protein Name

Protein PML

UniProt Synonym Protein Names

Promyelocytic leukemia protein; RING finger protein 71; Tripartite motif-containing protein 19

Protein Family

Protein

UniProt Gene Name

PML

UniProt Synonym Gene Names

MYL; PP8675; RNF71; TRIM19

UniProt Entry Name

PML_HUMAN

NCBI Protein Information

protein PML

NCBI Summary for PML

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

UniProt Comments for PML

PML: a zinc-finger protein that can regulate transcription and can localize to nuclear bodies. Cytoplasmic forms regulate glycolysis by inhibiting the tetrameric form of PKM2. Together with SATB1, involved in local chromatin-loop remodeling and gene expression regulation at the MHC-I locus. Interacts with SIRT1, TOPBP1, TRIM27 and TRIM69. Sumoylated forms interact with SATB1 and localize to the PML nuclear bodies. Sumoylation on three sites is required for nuclear body formation. Sumoylation on Lys-160 is a prerequisite for sumoylation on Lys-65. The B1 box and the RING finger are also required for localization to nuclear bodies. May play an important role in recruitment of ELF4 into PML nuclear bodies. A chromosomal aberration involving PML can cause acute promyelocytic leukemia (APL). Seven alternatively-spliced human isoforms have been reported.

Protein type: Nucleolus; Oncoprotein; Transcription factor; Tumor suppressor; Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 15q22

Cellular Component: cytoplasm; cytosol; nuclear chromosome, telomeric region; nuclear membrane; nucleolus; nucleoplasm; nucleus; PML body

Molecular Function: protein binding; protein homodimerization activity; SUMO binding; ubiquitin protein ligase binding

Biological Process: circadian regulation of gene expression; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis; endoplasmic reticulum calcium ion homeostasis; entrainment of circadian clock by photoperiod; innate immune response; maintenance of protein localization in nucleus; negative regulation of angiogenesis; negative regulation of cell growth; negative regulation of cell proliferation; negative regulation of transcription, DNA-dependent; PML body organization and biogenesis; positive regulation of telomere maintenance; proteasomal ubiquitin-dependent protein catabolic process; protein complex assembly; protein sumoylation; regulation of circadian rhythm; regulation of protein amino acid phosphorylation; regulation of transcription, DNA-dependent; response to cytokine stimulus; response to hypoxia

Research Articles on PML

1. Our work provides a novel view of the physiologic function of PML, which participates in telomeres surveillance in normal cells. Our data further imply that a diminished PML function may contribute to cell senescence, genomic instability and tumorigenesis

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with PML cdna clone

Products by Pathway	Pathway Diagram
Acute Myeloid Leukemia Pathway antibodies	Acute Myeloid Leukemia Pathway Diagram
Acute Myeloid Leukemia Pathway antibodies	Acute Myeloid Leukemia Pathway Diagram
Cytokine Signaling In Immune System Pathway antibodies	Cytokine Signaling In Immune System Pathway Diagram
DNA Damage Response Pathway antibodies	DNA Damage Response Pathway Diagram
Direct P53 Effectors Pathway antibodies	Direct P53 Effectors Pathway Diagram
Endocytosis Pathway antibodies	Endocytosis Pathway Diagram
Endocytosis Pathway antibodies	Endocytosis Pathway Diagram
Herpes Simplex Infection Pathway antibodies	Herpes Simplex Infection Pathway Diagram
Herpes Simplex Infection Pathway antibodies	Herpes Simplex Infection Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram

Diseases associated with PML cdna clone

Disease Name	Pubmed Publications
Neoplasms Antibodies	>1994 publications with PML and Neoplasms
Leukemia, Promyelocytic, Acute Antibodies	>1504 publications with PML and Leukemia, Promyelocytic, Acute
Neoplasms, Experimental Antibodies	>147 publications with PML and Neoplasms, Experimental
Cell Transformation, Neoplastic Antibodies	>147 publications with PML and Cell Transformation, Neoplastic
Drug Toxicity Antibodies	>103 publications with PML and Drug Toxicity
Necrosis Antibodies	>71 publications with PML and Necrosis
Heart Diseases Antibodies	>66 publications with PML and Heart Diseases
Inflammation Antibodies	>65 publications with PML and Inflammation
Liver Diseases Antibodies	>57 publications with PML and Liver Diseases
Gastrointestinal Diseases Antibodies	>50 publications with PML and Gastrointestinal Diseases

Organs/Tissues associated with PML cdna clone

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>829 publications with PML and Blood
Brain Antibodies	>813 publications with PML and Brain
Bone Antibodies	>435 publications with PML and Bone
Kidney Antibodies	>112 publications with PML and Kidney
Liver Antibodies	>107 publications with PML and Liver
Nerve Antibodies	>106 publications with PML and Nerve
Lung Antibodies	>84 publications with PML and Lung
Heart Antibodies	>82 publications with PML and Heart
Skin Antibodies	>59 publications with PML and Skin
Vascular Antibodies	>47 publications with PML and Vascular