Human RASGRP1 cDNA Clone Expression Plasmid – Cat# MBS1277831

RASGRP1 cDNA Clone – RAS Guanyl Releasing Protein 1 (Calcium and DAG-Regulated) (Human)

Name: RASGRP1 cDNA Clone; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1277831
Price: 895 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1277831

MBS1277831 is a cDNA clone targeting RASGRP1. More details

$895 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

RASGRP1, cDNA Clone

Full Product Name

RASGRP1 cDNA Clone

Product Gene Name

RASGRP1 cdna clone

Sequence

ATGGGCACCC TGGGCAAGGC GAGAGAGGCT CCGCGGAAAC CTTCCCATGG CTGCAGAGCT GCCTCTAAAG CAAGACTAGA GGCAAAGCCA GCCAACAGCC CCTTCCCCTC CCATCCCAGC TTGGCCCACA TCACCCAGTT CCGAATGATG GTGTCTCTGG GACATTTAGC CAAAGGAGCC AGCCTGGACG ATCTCATTGA CAGCTGCATT CAATCTTTTG ATGCAGATGG AAACCTGTGT CGAAGTAACC AACTGTTGCA AGTCATGCTG ACCATGCACC GAATTGTCAT CTCCTCTGCA GAACTGCTCC AAAAAGTTAT CACCCTCTAT AAGGATGCTT TGGCAAAGAA TTCACCAGGA CTTTGCCTGA AGATCTGTTA TTTTGTAAGG TATTGGATAA CAGAATTCTG GGTCATGTTT AAAATGGACG CCAGCTTGAC AGACACTATG GAGGAGTTTC AGGAACTGGT GAAAGCTAAG GGTGAGGAGT TACATTGCCG CCTGATTGAC ACAACTCAAA TCAATGCCCG TGACTGGTCC AGGAAACTTA CTCAAAGGAT AAAATCAAAT ACCAGCAAGA AACGGAAAGT CTCCCTGCTC TTTGACCATC TGGAACCAGA AGAGCTATCC GAGCACCTCA CCTACCTTGA GTTCAAGTCT TTCCGGAGGA TATCGTTCTC TGATTATCAG AATTACCTTG TAAATAGCTG TGTGAAGGAA AACCCCACCA TGGAGCGATC TATTGCTCTG TGCAACGGCA TCTCCCAGTG GGTACAACTG ATGGTTCTCA GCCGCCCCAC GCCGCAGCTC CGAGCAGAAG TCTTCATCAA GTTCATCCAG GTGGCTCAGA AGCTCCACCA ACTACAGAAC TTCAATACAC TGATGGCTGT GATAGGTGGG CTGTGTCACA GCTCAATCTC GAGGCTCAAG GAGACAAGTT CGCATGTCCC ACATGAAATC AATAAGGTTC TCGGTGAGAT GACTGAGCTG CTGTCCTCCT CCAGAAACTA CGACAATTAC CGGCGAGCCT ATGGAGAGTG CACCGACTTC AAGATCCCCA TTCTGGGTGT GCATCTCAAG GACCTCATCT CCCTGTATGA AGCCATGCCT GACTATCTGG AGGACGGGAA AGTGAACGTC CATAAGCTAC TGGCCCTATA CAATCATATC AGTGAATTGG TCCAGCTGCA AGAGGTGGCC CCACCCTTGG AGGCTAACAA GGACTTGGTA CACTTGCTGA CGTTATCCCT GGATCTTTAC TACACTGAGG ATGAAATCTA TGAGCTTTCC TATGCCCGGG AACCAAGGAA CCACAGAGCT CCACCACTAA CACCTTCAAA GCCACCAGTA GTAGTGGACT GGGCTTCTGG AGTGTCTCCC AAACCTGATC CAAAAACCAT TAGCAAACAC GTCCAGAGGA TGGTGGATTC TGTCTTCAAG AACTATGATC ACGACCAGGA TGGATACATT TCTCAGGAAG AATTTGAAAA GATTGCTGCG AGTTTTCCAT TTTCCTTCTG TGTGATGGAC AAAGACAGGG AAGGCCTCAT CAGCAGGGAT GAGATCACAG CCTACTTCAT GAGAGCCAGC TCAATCTATT CCAAGCTGGG CCTGGGCTTT CCTCACAACT TCCAAGAGAC CACCTACCTG AAGCCCACTT TTTGTGACAA CTGTGCTGGA TTTCTCTGGG GAGTGATCAA ACAAGGATAT CGATGTAAAG ACTGCGGGAT GAACTGTCAC AAACAATGCA AAGATCTGGT TGTGTTTGAG TGTAAGAAGC GAGCCAAGAA CCCAGTAGCT CCCACAGAGA ACAACACTTC TGTGGGGCCA GTGTCCAACC TTTGCTCATT GGGAGCCAAA GATCTGCTCC ATGCACCTGA GGAAGGACCT TTTACATTCC CTAATGGGGA GGCTGTGGAA CATGGTGAGG AGAGTAAGGA TCGGACCATC ATGCTGATGG GAGTGTCCTC ACAGAAGATT TCTCTTCGGC TGAAGAGGGC TGTTGCCCAC AAGGCCACCC AGACTGAATC ACAGCCTTGG ATTGGCAGTG AGGGCCCTTC AGGTCCCTTT GTGCTGTCTT CCCCAAGGAA GACAGCCCAG GATACTCTAT ATGTGCTTCC CAGTCCCACC TCTCCATGTC CTAGCCCAGT CTTGGTCAGA AAGCGGGCTT TTGTCAAGTG GGAGAATAAA GACTCCCTCA TAAAATCAAA GGAGGAGCTC CGTCACCTCA GACTGCCTAC CTACCAAGAA CTGGAACAGG AAATAAATAC TCTGAAAGCA GATAATGATG CCCTAAAGAT CCAACTGAAA TATGCACAGA AGAAAATAGA ATCCCTCCAG CTTGAAAAAA GCAATCATGT CTTAGCTCAA ATGGAGCAGG GTGACTGTTC TTAG

Molecular Weight

62,674 Da

OMIM

152700

Vector

Please Inquire

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of RASGRP1 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for RASGRP1. It may not necessarily be applicable to this product.

NCBI GI #

80475961

NCBI GeneID

10125

NCBI Accession #

BC109297

UniProt Secondary Accession #

Q56CZ0; Q58G75; Q59HB1; Q5I3A8; Q6GV31; Q6NX39; Q7LDG6; Q9UI94; Q9UNN9

UniProt Related Accession #

O95267

NCBI Official Full Name

Homo sapiens RAS guanyl releasing protein 1 (calcium and DAG-regulated), mRNA

NCBI Official Synonym Full Names

RAS guanyl releasing protein 1

NCBI Official Symbol

RASGRP1

NCBI Official Synonym Symbols

V; RASGRP; hRasGRP1; CALDAG-GEFI; CALDAG-GEFII

UniProt Protein Name

RAS guanyl-releasing protein 1

UniProt Synonym Protein Names

Calcium and DAG-regulated guanine nucleotide exchange factor II; CalDAG-GEFII; Ras guanyl-releasing protein

Protein Family

RAS guanyl-releasing protein

UniProt Gene Name

RASGRP1

UniProt Synonym Gene Names

RASGRP; CalDAG-GEFII

UniProt Entry Name

GRP1_HUMAN

NCBI Protein Information

RAS guanyl-releasing protein 1

NCBI Summary for RASGRP1

This gene is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. It activates the Erk/MAP kinase cascade and regulates T-cells and B-cells development, homeostasis and differentiation. Alternatively spliced transcript variants encoding different isoforms have been identified. Altered expression of the different isoforms of this protein may be a cause of susceptibility to systemic lupus erythematosus (SLE). [provided by RefSeq, Jul 2008]

UniProt Comments for RASGRP1

RASGRP1: Functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. Activates the Erk/MAP kinase cascade. Couples T-lymphocytes and B-lymphocytes antigen receptors to the activation of Ras. Hence, regulates T-cells and B-cells development, homeostasis and differentiation. Functions also in FcERI-evoked degranulation and cytokine secretion by mast cells, regulating allergic responses. May also function in other cell types differentiation. Defects in RASGRP1 may contribute to susceptibility to systemic lupus erythematosus (SLE). SLE is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. SLE is thought to represent a failure of the regulatory mechanisms of the autoimmune system. Aberrantly spliced isoforms and/or diminished levels of RASGRP1 are found in a cohort of SLE patients raising the possibility that dysregulation of this signaling protein contributes to the development of autoimmunity in a subset of SLE patients. Belongs to the RASGRP family. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: GEFs; GEFs, Ras

Chromosomal Location of Human Ortholog: 15q14

Cellular Component: cytosol; Golgi apparatus; membrane; plasma membrane

Molecular Function: calcium ion binding; diacylglycerol binding; guanyl-nucleotide exchange factor activity; lipid binding; phosphatidylcholine binding; phosphatidylserine binding; protein homodimerization activity; Ras guanyl-nucleotide exchange factor activity; zinc ion binding

Biological Process: MAPKKK cascade; positive regulation of granulocyte macrophage colony-stimulating factor production; positive regulation of GTPase activity; positive regulation of JNK cascade; positive regulation of MAP kinase activity; positive regulation of natural killer cell mediated cytotoxicity; positive regulation of protein amino acid phosphorylation; positive regulation of Ras protein signal transduction; positive regulation of tumor necrosis factor production; protein oligomerization; signal transduction

Research Articles on RASGRP1

1. This study aimed to replicate and verify the association of RASGRP1 tag single-nucleotide polymorphisms with T2D in a Chinese Han population.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with RASGRP1 cdna clone

Products by Pathway	Pathway Diagram
Activation Of RAS In B Cells Pathway antibodies	Activation Of RAS In B Cells Pathway Diagram
Adaptive Immune System Pathway antibodies	Adaptive Immune System Pathway Diagram
Downstream Signaling Events Of B Cell Receptor (BCR) Pathway antibodies	Downstream Signaling Events Of B Cell Receptor (BCR) Pathway Diagram
Effects Of PIP2 Hydrolysis Pathway antibodies	Effects Of PIP2 Hydrolysis Pathway Diagram
G Alpha (q) Signalling Events Pathway antibodies	G Alpha (q) Signalling Events Pathway Diagram
GPCR Downstream Signaling Pathway antibodies	GPCR Downstream Signaling Pathway Diagram
Gastrin-CREB Signalling Pathway Via PKC And MAPK antibodies	Gastrin-CREB Signalling Pathway Via PKC And MAPK Diagram
Hemostasis Pathway antibodies	Hemostasis Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
Integrin AlphaIIb Beta3 Signaling Pathway antibodies	Integrin AlphaIIb Beta3 Signaling Pathway Diagram

Diseases associated with RASGRP1 cdna clone

Disease Name	Pubmed Publications
Neoplasms Antibodies	>22 publications with RASGRP1 and Neoplasms
Leukemia, Myeloid, Acute Antibodies	>6 publications with RASGRP1 and Leukemia, Myeloid, Acute
Necrosis Antibodies	>4 publications with RASGRP1 and Necrosis
Neoplasms, Experimental Antibodies	>3 publications with RASGRP1 and Neoplasms, Experimental
Nervous System Diseases Antibodies	>3 publications with RASGRP1 and Nervous System Diseases
Edema Antibodies	>1 publications with RASGRP1 and Edema
Liver Diseases Antibodies	>1 publications with RASGRP1 and Liver Diseases
Inflammation Antibodies	>1 publications with RASGRP1 and Inflammation
Drug-Induced Liver Injury Antibodies	>1 publications with RASGRP1 and Drug-Induced Liver Injury
Breast Neoplasms Antibodies	>1 publications with RASGRP1 and Breast Neoplasms

Organs/Tissues associated with RASGRP1 cdna clone

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>76 publications with RASGRP1 and Blood
Brain Antibodies	>17 publications with RASGRP1 and Brain
Thymus Antibodies	>15 publications with RASGRP1 and Thymus
Spleen Antibodies	>5 publications with RASGRP1 and Spleen
Kidney Antibodies	>4 publications with RASGRP1 and Kidney
Eye Antibodies	>2 publications with RASGRP1 and Eye
Liver Antibodies	>2 publications with RASGRP1 and Liver
Muscle Antibodies	>1 publications with RASGRP1 and Muscle
Pancreas Antibodies	>1 publications with RASGRP1 and Pancreas
Ovary Antibodies	>1 publications with RASGRP1 and Ovary