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SMPD3 cDNA Clone – Sphingomyelin Phosphodiesterase 3, Neutral Membrane (Neutral Sphingomyelinase II) (Human)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1269593

MBS1269593 is a cDNA clone targeting SMPD3. More details

$400 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
SMPD3, cDNA Clone
Full Product Name
SMPD3 cDNA Clone
Product Gene Name
SMPD3 cdna clone
Sequence
ATGGTTTTGT ACACGACCCC CTTTCCTAAC AGCTGTCTGT CCGCCCTGCA CTGTGTGTCC TGGGCCCTTA TCTTTCCATG CTACTGGCTG GTGGACCGGC TCGCTGCCTC CTTCATACCC ACCACCTACG AGAAGCGCCA GCGGGCAGAC GACCCGTGCT GCCTGCAGCT GCTCTGCACT GCCCTCTTCA CGCCCATCTA CCTGGCCCTC CTGGTGGCCT CGCTGCCCTT TGCGTTTCTC GGCTTTCTCT TCTGGTCCCC ACTGCAGTCG GCCCGCCGGC CCTACATCTA TTCACGGCTG GAAGACAAGG GCCTGGCCGG TGGGGCAGCC CTGCTCAGTG AATGGAAGGG CACGGGGCCT GGCAAAAGCT TCTGCTTTGC CACTGCCAAC GTCTGCCTCC TGCCCGACTC ACTCGCCAGG GTCAACAACC TTTTTAACAC CCAAGCGCGG GCCAAGGAGA TCGGGCAGAG AATCCGCAAT GGGGCCGCCC GGCCCCAGAT CAAAATTTAC ATCGACTCCC CCACCAATAC CTCCATCAGC GCCGCTAGCT TCAGCAGCCT GGTGTCACCA CAGGGCGGCG ATGGGGTGGC CCGGGCCGTC CCCGGGAGCA TTAAGAGGAC AGCCTCTGTG GAGTACAAGG GTGACGGTGG GCGGCACCCC GGTGACGAGG CTGCCAACGG CCCAGCCTCT GGGGACCCTG TCGACAGCAG CAGCCCGGAG GATGCCTGCA TCGTGCGCAT CGGTGGCGAG GAGGGCGGCC GGCCACCTGA AGCTGACGAC CCTGTGCCTG GGGGCCAGGC CAGGAACGGA GCTGGCGGGG GCCCAAGGGG CCAGACGCCC AACCATAATC AGCAGGACGG GGATTCAGGG AGCCTGGGCA GCCCCTCGGC CTCCCGGGAG TCCCTGGTGA AGGGGCGAGC TGGGCCAGAC ACCAGTGCCA GCGGGGAGCC AGGTGCCAAC AGCAAGCTCC TGTACAAGGC CTCGGTGGTG AAGAAGGCGG CTGCACGCAG GAGGCGGCAC CCCGACGAGG CCTTCGACCA TGAGGTCTCC GCCTTCTTCC CCGCCAACCT GGACTTCCTG TGCCTGCAGG AGGTGTTTGA CAAGCGAGCA GCCACCAAAT TGAAAGAGCA GCTGCACGGC TACTTCGAGT ACATCCTGTA CGACGTCGGG GTCTACGGCT GCCAGGGCTG CTGCAGCTTC AAGTGTCTCA ACAGCGGCCT CCTCTTTGCC AGCCGCTACC CCATCATGGA CGTGGCCTAT CACTGTTACC CCAACAAGTG TAACGACGAT GCCCTGGCCT CTAAGGGAGC TCTGTTTCTC AAGGTGCAGG TGGGAAGCAC ACCTCAGGAC CAAAGAATCG TCGGGTACAT CGCCTGCACA CACCTGCATG CCCCGCAAGA GGACAGCGCC ATCCGGTGTG GGCAGCTGGA CCTGCTTCAG GACTGGCTGG CTGATTTCCG AAAATCTACC TCCTCGTCCA GCGCAGCCAA CCCCGAGGAG CTGGTGGCAT TTGACGTCGT CTGTGGAGAT TTCAACTTTG ATAACTGCTC CTCTGACGAC AAGCTGGAGC AGCAACACTC CCTGTTCACC CACTACAGGG ACCCCTGCCG CCTGGGGCCT GGTGAGGAGA AGCCGTGGGC CATCGGTACT CTGCTGGACA CGAACGGCCT GTACGATGAG GATGTGTGCA CCCCCGACAA CCTGCAGAAG GTCCTGGAGA GTGAGGAGGG CCGCAGGGAG TACCTGGCGT TTCCCACCAG CAAGAGCTCG GGCCAGAAGG GGCGGAAGGA GCTGCTGAAG GGCAACGGCC GGCGCATCGA CTACATGCTG CATGCAGAGG AGGGGCTGTG CCCAGACTGG AAGGCCGAGG TGGAAGAATT CAGTTTTATC ACCCAGCTGT CCGGCCTGAC GGACCACCTG CCAGTAGCCA TGCGACTGAT GGTGTCTTCG GGGGAGGAGG AGGCATAG
Molecular Weight
70,170 Da
OMIM
605777
Vector
pENTR223.1 or pUC
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of SMPD3 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for SMPD3. It may not necessarily be applicable to this product.

NCBI GI #
85567663
NCBI GeneID
55512
NCBI Accession #
BC112238
UniProt Secondary Accession #
Q2M1S8; B7ZL82
UniProt Related Accession #
Q9NY59
NCBI Official Full Name
Homo sapiens sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II), mRNA
NCBI Official Synonym Full Names
sphingomyelin phosphodiesterase 3
NCBI Official Symbol
SMPD3
NCBI Official Synonym Symbols
NSMASE2
UniProt Protein Name
Sphingomyelin phosphodiesterase 3
UniProt Synonym Protein Names
Neutral sphingomyelinase 2; nSMase-2; nSMase2; Neutral sphingomyelinase II
Protein Family
Sphingomyelin phosphodiesterase
UniProt Gene Name
SMPD3
UniProt Synonym Gene Names
nSMase-2; nSMase2
UniProt Entry Name
NSMA2_HUMAN
NCBI Protein Information
sphingomyelin phosphodiesterase 3

UniProt Comments for SMPD3

SMPD3: Catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular functions, such as apoptosis and growth arrest, and is capable of regulating these 2 cellular events independently. Also hydrolyzes sphingosylphosphocholine. Regulates the cell cycle by acting as a growth suppressor in confluent cells. Probably acts as a regulator of postnatal development and participates in bone and dentin mineralization. Belongs to the neutral sphingomyelinase family.

Protein type: Membrane protein, integral; EC 3.1.4.12; Phospholipase; Lipid Metabolism - sphingolipid

Chromosomal Location of Human Ortholog: 16q22.1

Cellular Component: plasma membrane

Biological Process: glycosphingolipid metabolic process; sphingomyelin catabolic process
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Research Articles on SMPD3

1. These results suggest that OTC is a potent stimulant of nSMase-2 expression and that there may be unanticipated complications of OTC supplementation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with SMPD3 cdna clone

 Products by Pathway  Pathway Diagram
 Ceramide Signaling Pathway antibodies  Ceramide Signaling Pathway Diagram
 Glycosphingolipid Metabolism Pathway antibodies  Glycosphingolipid Metabolism Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Sphingolipid Metabolism Pathway antibodies  Sphingolipid Metabolism Pathway Diagram
 Sphingolipid Metabolism Pathway antibodies  Sphingolipid Metabolism Pathway Diagram
 Sphingolipid Metabolism Pathway antibodies  Sphingolipid Metabolism Pathway Diagram
 Sphingomyelin Metabolism Pathway antibodies  Sphingomyelin Metabolism Pathway Diagram

Diseases associated with SMPD3 cdna clone

 Disease Name  Pubmed Publications
 Necrosis Antibodies  >14 publications with SMPD3 and Necrosis
 Neoplasms Antibodies  >12 publications with SMPD3 and Neoplasms
 Inflammation Antibodies  >8 publications with SMPD3 and Inflammation
 Disease Models, Animal Antibodies  >6 publications with SMPD3 and Disease Models, Animal
 Nervous System Diseases Antibodies  >6 publications with SMPD3 and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >2 publications with SMPD3 and Cardiovascular Diseases
 Neurodegenerative Diseases Antibodies  >2 publications with SMPD3 and Neurodegenerative Diseases
 Carcinoma Antibodies  >2 publications with SMPD3 and Carcinoma
 Fatty Liver Antibodies  >2 publications with SMPD3 and Fatty Liver
 Learning Disorders Antibodies  >1 publications with SMPD3 and Learning Disorders

Organs/Tissues associated with SMPD3 cdna clone

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >11 publications with SMPD3 and Brain
 Lung Antibodies  >7 publications with SMPD3 and Lung
 Muscle Antibodies  >7 publications with SMPD3 and Muscle
 Bone Antibodies  >6 publications with SMPD3 and Bone
 Blood Antibodies  >4 publications with SMPD3 and Blood
 Embryonic Tissue Antibodies  >3 publications with SMPD3 and Embryonic Tissue
 Connective Tissue Antibodies  >3 publications with SMPD3 and Connective Tissue
 Nerve Antibodies  >2 publications with SMPD3 and Nerve
 Adipose Tissue Antibodies  >2 publications with SMPD3 and Adipose Tissue
 Skin Antibodies  >1 publications with SMPD3 and Skin
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