Human SPG20 cDNA Clone Expression Plasmid – Cat# MBS1269871

SPG20 cDNA Clone – Spastic Paraplegia 20 (Troyer Syndrome) (Human)

Name: SPG20 cDNA Clone; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1269871
Price: 520 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1269871

MBS1269871 is a cDNA clone targeting SPG20. More details

$520 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

SPG20, cDNA Clone

Full Product Name

SPG20 cDNA Clone

Product Gene Name

SPG20 cdna clone

Sequence

atggagcaag agccacaaaa tggagaacct gctgaaatta agatcatcag agaagcatat aagaaggcct ttttatttgt taacaaaggt ctgaatacag atgaattagg tcagaaggaa gaagcaaaga actactataa gcaaggaata ggacacctgc tcagagggat cagcatttca tcaaaagagt ctgaacacac aggtactggg tgggaatctg ctagacagat gcaacagaaa atgaaagaaa ctctacagaa tgtacgcacc aggctggaaa ttctagagaa gggtcttgcc acttctctgc agaatgatct tcaggaggtg cccaagttat atccagaatt tccacctaaa gacatgtgtg aaaaattacc agagcctcag tcttttagtt cagctcctca gcatgctgaa gtaaatggaa acacctcaac tccaagtgca ggggcagttg ctgcacctgc ttctctgtct ttaccatcac aaagttgtcc agcagaagct cctcctgctt atactcctca agctgctgaa ggtcactaca ctgtatccta tggaacagat tctggggagt tttcatcagt tggagaggag ttttatagga atcattctca gccaccgcct cttgagacct tagggctgga tgcagatgaa ttgattttga taccaaatgg agtacagatt ttttttgtaa atcctgcagg ggaggttagt gcaccttcgt atcctgggta ccttcgaatt gtgaggtttt tggataattc tctcgatacg gttctaaacc gtcctcccgg gtttcttcag gtttgtgact ggttatatcc tctagttcct gatagatctc cggttctgaa atgtactgcg ggagcctaca tgtttcctga tacaatgcta caagcagcag gatgctttgt gggggtcgtc ctgtcctctg agttaccaga ggatgataga gagctctttg aggatctgtt aaggcaaatg tctgaccttc ggctccaggc caactggaac agagcagaag aagaaaatga attccaaatc cctggaagaa ctagaccctc ctctgaccaa ctaaaagaag cctctggcac tgatgtgaaa cagttggacc aaggcaataa ggatgtacgt cataaaggaa aacgtggaaa aagggctaaa gatacttcaa gtgaagaagt taacctgagt cacattgtac catgtgagcc agttccagaa gaaaagccaa aagaattaca tgaatggagt gaaaaagtgg ctcacaacat tttgtcaggt gcttcctggg tgagttgggg tttagtcaaa ggtgctgaga ttactggtaa ggcaatccag aaaggtgctt ctaaactccg agagcggatt caaccagaag aaaaacccgt ggaagttagt ccagctgtca ccaagggact ttatatagcg aagcaagcta caggaggagc agcaaaagtc agtcagttcc tggttgatgg agtttgcact gtagcaaatt gcgttggaaa agaactagct ccacatgtca agaagcatgg aagcaaactt gttccagaat ctcttaaaaa agacaaagat gggaaatctc ctctggatgg tgctatggtt gtagcagcga gtagtgttca aggattttca actgtctggc aaggattgga atgtgcagct aaatgcatcg ttaacaatgt ttcagcagaa actgtacaaa ctgtcagata caaatacgga tataatgcag gagaagctac ccaccatgcg gtggattctg cggtcaatgt tggcgtaact gcctacaata ttaacaacat tggtatcaaa gcaatggtga agaaaactgc aacacaaaca ggacacactc tccttgagga ctatcagata gttgataatt ctcagaggga aaatcaagaa ggagcagcaa atgtcaacgt gagaggggag aaggatgagc agacgaagga agtaaaggag gcaaagaaga aagataaatg a

Molecular Weight

72,833 Da

OMIM

275900

Vector

pENTR223.1 or pUC

Clone Sequence Report

Provided with product shipment

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of SPG20 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for SPG20. It may not necessarily be applicable to this product.

NCBI GI #

28436884

NCBI GeneID

23111

NCBI Accession #

BC047083

UniProt Secondary Accession #

O60349; Q86Y67; Q9H1T2; Q9H1T3

UniProt Related Accession #

Q8N0X7

NCBI Official Full Name

Homo sapiens spastic paraplegia 20 (Troyer syndrome), mRNA

NCBI Official Synonym Full Names

spastic paraplegia 20 (Troyer syndrome)

NCBI Official Symbol

SPG20

NCBI Official Synonym Symbols

SPARTIN; TAHCCP1

UniProt Protein Name

Spartin

UniProt Synonym Protein Names

Spastic paraplegia 20 protein; Trans-activated by hepatitis C virus core protein 1

Protein Family

Spartin

UniProt Gene Name

SPG20

UniProt Synonym Gene Names

KIAA0610; TAHCCP1

UniProt Entry Name

SPG20_HUMAN

NCBI Protein Information

spartin

NCBI Summary for SPG20

This gene encodes a protein containing a MIT (Microtubule Interacting and Trafficking molecule) domain, and is implicated in regulating endosomal trafficking and mitochondria function. The protein localizes to mitochondria and partially co-localizes with microtubules. Stimulation with epidermal growth factor (EGF) results in protein translocation to the plasma membrane, and the protein functions in the degradation and intracellular trafficking of EGF receptor. Multiple alternatively spliced variants, encoding the same protein, have been identified. Mutations associated with this gene cause autosomal recessive spastic paraplegia 20 (Troyer syndrome). [provided by RefSeq, Nov 2008]

UniProt Comments for SPG20

SPG20: May be implicated in endosomal trafficking, or microtubule dynamics, or both. Defects in SPG20 are the cause of spastic paraplegia autosomal recessive type 20 (SPG20); also known as Troyer syndrome (TRS). Spastic paraplegia is a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body. SPG20 is characterized by dysarthria, distal amyotrophy, mild developmental delay and short stature.

Protein type: Unknown function

Chromosomal Location of Human Ortholog: 13q13.3

Cellular Component: cytoplasm; midbody; mitochondrial outer membrane; plasma membrane

Molecular Function: protein binding; ubiquitin protein ligase binding

Biological Process: abscission; cell division; regulation of mitochondrial membrane potential

Disease: Spastic Paraplegia 20, Autosomal Recessive

Research Articles on SPG20

1. Up-regulation of SPG20 expression, brought about by trisomy 13 in colon cancer cells trisomy 13 amniocytes, is sufficient for the cytokinesis failure phenotype.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with SPG20 cdna clone

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>23 publications with SPG20 and Nervous System Diseases
Spastic paraplegia 20, autosomal recessive Antibodies	>3 publications with SPG20 and Spastic paraplegia 20, autosomal recessive
Disease Models, Animal Antibodies	>2 publications with SPG20 and Disease Models, Animal
Atrophy Antibodies	>1 publications with SPG20 and Atrophy
Kidney Diseases Antibodies	>1 publications with SPG20 and Kidney Diseases

Organs/Tissues associated with SPG20 cdna clone

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>7 publications with SPG20 and Brain
Bone Antibodies	>3 publications with SPG20 and Bone
Embryonic Tissue Antibodies	>2 publications with SPG20 and Embryonic Tissue
Connective Tissue Antibodies	>1 publications with SPG20 and Connective Tissue
Muscle Antibodies	>1 publications with SPG20 and Muscle
Bladder Antibodies	>1 publications with SPG20 and Bladder
Blood Antibodies	>1 publications with SPG20 and Blood
Intestine Antibodies	>1 publications with SPG20 and Intestine
Skin Antibodies	>1 publications with SPG20 and Skin
Kidney Antibodies	>1 publications with SPG20 and Kidney